10.5878/002921
Dencker, Magnus
Magnus
Dencker
Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
Cystatin B, cathepsin L och D relaterat till andra riskfaktorer för hjärt-och kärlsjukdom hos barn
Lund University
2017
Risk Factors
Riskfaktorer
Child
Barn
Cardiovascular Diseases
Kardiovaskulära sjukdomar
Cathepsin D
Katepsin D
Skinfold Thickness
Kroppsfettsmätning
Cystatin B
Cystatin B
Cathepsin L
Katepsin L
Age Groups
Åldersgrupper
Body Weights and Measures
Kroppsvikt och kroppsmått
Cathepsins
Katepsiner
Cysteine Endopeptidases
Cysteinendopeptidaser
Risk
Risk
Cystatins
Cystatiner
Causality
Orsakssammanhang
Aspartic Acid Endopeptidases
Asparaginendopeptidaser
Persons
Personer
Anthropometry
Antropometri
Body Constitution
Kroppskonstitution
Epidemiologic Factors
Epidemiologiska faktorer
Proteins
Proteiner
Peptide Hydrolases
Peptidhydrolaser
Endopeptidases
Endopeptidaser
Probability
Sannolikhet
Aspartic Acid Proteases
Asparaginsyraproteaser
Cysteine Proteases
Cysteinproteaser
Physical Examination
Hälsokontroll
Public Health
Folkhälsa
Statistics as Topic
Statistik som ämne
Amino Acids, Peptides, and Proteins
Aminosyror, peptider och proteiner
Biometry
Biometri
Hydrolases
Hydrolaser
Physiological Phenomena
Fysiologiska fenomen
Quality of Health Care
Vårdkvalitet
Mathematical Concepts
Matematiska begrepp
Environment and Public Health
Miljö och folkhälsa
Epidemiologic Methods
Epidemiologiska metoder
Medicine
Medicin
Health
Hälsa
Enzymes
Enzymer
Health Services Administration
Hälso- och sjukvårdsadministration
Mathematics
Matematik
Epidemiologic Measurements
Epidemiologiska mätningar
Health Care Quality, Access, and Evaluation
Vårdkvalitet, tillgång och utvärdering
Health Care Evaluation Mechanisms
Utvärderingsmetoder för hälso- och sjukvård
Diagnostic Techniques and Procedures
Diagnostiska tekniker och metoder
Diagnosis
Diagnos
Investigative Techniques
Utredningsmetoder
Population Characteristics
Befolkningskarakteristika
Health Occupations
Vårdyrken
Natural Science Disciplines
Naturvetenskaper
Enzymes and Coenzymes
Enzymer och koenzymer
Medical and Health Sciences
Medicin och hälsovetenskap
DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES)
DEMOGRAFI (POPULATION, VITALSTATISTIK OCH FOLKRÄKNINGAR)
2017-10-09
eng
10.5878/002920
273.27 KiB
33 variables
248 cases
1.0
Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years.
Conclusion: Findings from this community-based cohort of young children show that
surrogate markers for cardiovascular disease such as total fat mass, percent body fat,
abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D.
Purpose:
This study investigated potential associations between novel biomarkers for
cardiovascular disease (Cystatin B, cathepsin L and D9 and other surrogate markers for health.
Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Studien studerade relationen mellan traditionella och nya riskfaktorer för hjärt-och kärlsjukdom som Cystatin B, cathepsin L and D hos barn. Totalt studerade 170 bran i åldern 8-11 år. Cystatin B var svagt-måttligt relaterat till kropps fett och kondition medan cathepsin L and D inte var det.
Syfte:
Studera relationen mellan traditionella och nya riskfaktorer för hjärt-och kärlsjukdom som Cystatin B, cathepsin L and D hos barn
Följande mätningar är gjorda; Blodtryck, Fysisk prestationsförmåga, Ekokardiografi, DXA, Blodprov analyserade för cystatin B, cathepsin L och cathepsin D.
Sweden
Skåne County