Differences in metabolic profiles between the Burmese, the Maine Coon and the Birman cat - three breeds with varying risk for diabetes mellitus - Information on healthy cats of three breeds; Burmese, Birman and Maine coon. Data on the cats (e.g. age and weight) and on serum blood concentrations.
SND-ID: 2021-58-1. Version: 1. DOI: https://doi.org/10.5878/7qsz-6j80
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Bodil Ström Holst - Swedish University of Agricultural Sciences, Department of Clinical Sciences
Malin Öhlund - Medical Products Agency
Ali Moazzami - Swedish University of Agricultural Sciences, Department of Molecular Sciences
Elisabeth Mullner - Swedish University of Agricultural Sciences, Department of Molecular Sciences
Fredrick Anderson - Umeå university, Department of Medical Biosciences
Swedish University of Agricultural Sciences - Department of Clinical Sciences
Principal's reference number
Feline diabetes mellitus shares many features with type 2 diabetes in people, regarding clinical presentation, physiology, and pathology. A breed predisposition for type 2 diabetes has been identified, with the Burmese breed at a fivefold increased risk of developing the condition compared to other purebred cats. We aimed to characterize the serum metabolome in cats (n = 63) using nuclear magnetic resonance metabolomics, and to compare the metabolite pattern of Burmese cats with that of two cat breeds of medium or low risk of diabetes, the Maine coon (MCO) and Birman cat, respectively. Serum concentrations of adiponectin, insulin and insulin-like growth factor-1 were also measured (n = 94). Burmese cats had higher insulin and lower adiponectin concentrations than MCO cats. Twenty one metabolites were discriminative between breeds using a multivariate statistical approach and 15 remained significant after adjustment for body weight and body condition score. Burmese cats had higher plasma levels of 2-hydroxybutyrate relative to MCO and Birman cats and increased concentrations of 2-oxoisocaproic... Show more..
The study was approved by the ethics committee on animal experiments in Uppsala, reference number C 299/12 and C 12/15, and by the Swedish Board of Agriculture, reference number 31-11654/12.
Results from analysis of blood samples from healthy cats of three breeds: Burmese, Birman and Maine coon, are included. A clinical examination was performed on the cats and information noted. Hormones were analysed in serum using immunological methods. Lipoproteins were analysed using HPLC (high performance liquid chromatography) and metabolomics using NMR (nuclear magnetic resonance) spectroscopy. Show less..
Data contains personal data
- Time period(s) for data collection: 2013 – 2015
Geographic location: Sweden
Department of Clinical Sciences
Ulrika Hermansson - Swedish University of Agricultural Sciences, University Animal Hospital
Helene Hansson-Hamlin - Swedish Unversity of Agricultural Sciences, Department of Clinical Sciences
- Funding agency: Research Fund for Companion Animals at SLU
- Funding agency's reference number: 221760000
- Project name on the application: Diabetes hos katt- fokus på riskrasen Burma
Öhlund M, Müllner E, Moazzami A, Hermansson U, Pettersson A, Anderson F, Häggström J, Hansson-Hamlin H, Holst, BS (2021). Differences in metabolic profiles between the Burmese, the Maine coon and the Birman cat—Three breeds with varying risk for diabetes mellitus. PLoS ONE 16(4): e0249322
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