MISS-cohort, Melanoma in Southern Sweden - DNA

SND-ID: ext0102-2.

Is part of collection at SND: Swedish Cohort Consortium (Cohorts.se), Scania Metadatabase for Epidemiology (SME)

Access to data via


Creator/Principal investigator(s)

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Christian Ingvar - Lund University, Faculty of Medicine, Surgery

Research principal

Lund University - Faculty of Medicine rorId


The MISS cohort started in 1990 when 40 000 women between 26 and 65 in Skåne were randomly selected to participate in an interview about the risk factors for malignant melanoma and breast cancer. 29 508 (approximately 74%) of women surveyed chose to participate. None of the women had a history of cancer. The interviews were conducted between 1990 and 1992 and the questions concerned, among other things, the time for the woman's first menstruation, number of pregnancies, age at entry into menopause, contraception, alcohol, smoking, sun exposure and constitutional factors. The cohort was interviewed one more time in year 2000 and again 2011. Re-interviews are scheduled for every ten years. During 2011 to 2013 DNA was collected from the cohort through saliva. Follow-up of morbidity and mortality are made annually through the national registry.


The aim of this study was to create a prospective population-based cohort of women from Southern Sweden with information regarding environmental and genetic factors.
Method and outcome

Unit of analysis


Women between 25 and 65 years, living in Southern Sweden.

Sampling procedure

Time period(s) investigated

1990 – Ongoing

Number of individuals/objects


Response rate/participation rate

ca 50 %

Data format / data structure

Data collection
  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2011 – 2013
  • Source of the data: Population group, Biological samples
Geographic coverage

Geographic spread

Geographic description: Southern Sweden

Administrative information

Responsible department/unit

Faculty of Medicine

Topic and keywords

Research area

Medical genetics (Standard för svensk indelning av forskningsämnen 2011)

Clinical medicine (Standard för svensk indelning av forskningsämnen 2011)

Cancer and oncology (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)


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Olsson, H., & Bladström, A. (2002). A cohort study of reproductive factors and family history of breast cancer in southern Sweden. In Breast Cancer Research and Treatment (Vol. 76, Issue 3, pp. 203–209). https://doi.org/10.1023/A:1020807619092
DOI: https://doi.org/10.1023/A:1020807619092
SwePub: oai:lup.lub.lu.se:096e0995-6a13-4842-9d12-927d55735f91

Epstein, E., Lindqvist, P., Geppert, B., & Olsson, H. (n.d.). A population-based cohort study on sun habits and endometrial cancer. In British Journal of Cancer (Vol. 101, pp. 537–540). https://doi.org/10.1038/sj.bjc.6605149
Read full text
DOI: https://doi.org/10.1038/sj.bjc.6605149
SwePub: oai:lup.lub.lu.se:f9807fe6-83e1-46d7-a197-5c0db8909657

Epstein, E., Lindqvist, P., & Olsson, H. (2009). A population-based cohort study on the use of hormone treatment and endometrial cancer in southern Sweden. In International Journal of Cancer (Vol. 125, pp. 421–425). https://doi.org/10.1002/ijc.24284
DOI: https://doi.org/10.1002/ijc.24284
SwePub: oai:lup.lub.lu.se:d2daef20-4a0a-4921-bcf0-7d6b4c6a228f

Lindqvist, P. G., Epstein, E., & Olsson, H. (2009). Does an active sun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis. In Journal of Thrombosis and Haemostasis (Vol. 7, Issue 4, pp. 605–610). https://doi.org/10.1111/j.1538-7836.2009.03312.x
DOI: https://doi.org/10.1111/j.1538-7836.2009.03312.x
SwePub: oai:lup.lub.lu.se:f564874a-4b20-4f66-aab8-b0e83367d615

Lindqvist, P. G., Olsson, H., & Landin-Olsson, M. (2010). Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study? In Diabetes Research and Clinical Practice (Vol. 90, Issue 1, pp. 109–114). https://doi.org/10.1016/j.diabres.2010.06.007
DOI: https://doi.org/10.1016/j.diabres.2010.06.007
SwePub: oai:lup.lub.lu.se:5e5f3aa8-ff0c-455a-afd1-d591c814a35a

Lindqvist, P. G., Epstein, E., Landin-Olsson, M., Ingvar, C., Nielsen, K., Stenbeck, M., & Olsson, H. (n.d.). Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort. In Journal of Internal Medicine (Vol. 276, Issue 1, pp. 77–86). https://doi.org/10.1111/joim.12251
DOI: https://doi.org/10.1111/joim.12251
SwePub: oai:lup.lub.lu.se:c0300b35-18cc-4e3a-b294-7cee5077373a

Lindqvist, P. G., Epstein, E., Nielsen, K., Landin-Olsson, M., Ingvar, C., & Olsson, H. (n.d.). Avoidance of sun exposure as a risk factor for major causes of death : A competing risk analysis of the Melanoma in Southern Sweden cohort. In Journal of Internal Medicine (Vol. 280, Issue 4, pp. 375–387). https://doi.org/10.1111/joim.12496
DOI: https://doi.org/10.1111/joim.12496
SwePub: oai:lup.lub.lu.se:4c3d27ca-2a13-4fd8-9712-514c184adb8f

Lindqvist, P. G., Epstein, E., Landin-Olsson, M., Åkerlund, M., & Olsson, H. (n.d.). Women with fair phenotypes seem to confer a survival advantage in a low UV milieu. A nested matched case control study. In PLoS ONE (No. e0228582; Vol. 15, Issue 1). https://doi.org/10.1371/journal.pone.0228582
DOI: https://doi.org/10.1371/journal.pone.0228582
SwePub: oai:lup.lub.lu.se:27db91af-287b-4ec3-b851-2f5b749ee1b9

Lindqvist, P., Landin-Olsson, M., & Olsson, H. (n.d.). Low sun exposure habits is associated with a dose-dependent increased risk of hypertension: a report from the large MISS cohort. In Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (Vol. 20, Issue 2, pp. 285–292). https://doi.org/10.1007/s43630-021-00017-x
DOI: https://doi.org/10.1007/s43630-021-00017-x
SwePub: oai:prod.swepub.kib.ki.se:146011783

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