Rotational Thromboelastometry predicts care level in COVID-19

Creator/Principal investigator(s):

Lou Almskog - Karolinska Institutet, Department of Molecular Medicine and Surgery

Anna Ågren - Karolinska University Hospital / Danderyd Hospital, Coagulation Unit, Division of Hematology / Department of Clinical Sciences

Description:

The objective of the study was to test whether Rotational Thromboelastometry (ROTEM) indicate hypercoagulopathy at hospitalization of COVID-19 patients, and whether patients with severe disease have a more pronounced hypercoagulopathy compared with less severely ill patients.

The study was designed as a prospective observational study where COVID-19 positive patients over 18 years admitted to Capio St Göran’s Hospital in Stockholm, Sweden, were eligible for inclusion. Patients were divided into two groups depending on care level: 1) regular wards (40 patients) or 2) wards with specialized ventilation support (20 patients). ROTEM and other coagulation tests (see table for a list and explanation of variables) was taken after admission and the data were compared with ROTEM in healthy controls.

Conclusion
ROTEM variables (EXTEM-MCF, FIBTEM-MCF, EXTEM-CT, EXTEM-CFT) were significantly different in COVID-19 patients early after admission compared with healthy controls. This pattern was more pronounced in patients with increased disease severity, suggesting that ROTEM-analysis could be a potential

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Responsible department/unit:

Karolinska Institutet, Karolinska Institutet

Creator/Principal investigator(s):

Lou Almskog - Karolinska Institutet, Department of Molecular Medicine and Surgery

Anna Ågren - Karolinska University Hospital / Danderyd Hospital, Coagulation Unit, Division of Hematology / Department of Clinical Sciences

Contributor(s):

Jonas Svensson - Karolinska Institutet

Identifiers:

SND-ID: 2020-43

DOI: 10.1101/2020.06.11.20128710

Description:

The objective of the study was to test whether Rotational Thromboelastometry (ROTEM) indicate hypercoagulopathy at hospitalization of COVID-19 patients, and whether patients with severe disease have a more pronounced hypercoagulopathy compared with less severely ill patients.

The study was designed as a prospective observational study where COVID-19 positive patients over 18 years admitted to Capio St Göran’s Hospital in Stockholm, Sweden, were eligible for inclusion. Patients were divided into two groups depending on care level: 1) regular wards (40 patients) or 2) wards with specialized ventilation support (20 patients). ROTEM and other coagulation tests (see table for a list and explanation of variables) was taken after admission and the data were compared with ROTEM in healthy controls.

Conclusion
ROTEM variables (EXTEM-MCF, FIBTEM-MCF, EXTEM-CT, EXTEM-CFT) were significantly different in COVID-19 patients early after admission compared with healthy controls. This pattern was more pronounced in patients with increased disease severity, suggesting that ROTEM-analysis could be a potential

... Show more..

Language:

English

Time period(s) investigated:

2020-05-08 — 2020-05-31

Population:

Patients treated for COVID-19

Study design:

Observational study

Ethics Review:

Swedish Ethical Review Authority — Ref. D-nr 2020-01875

Contact for questions about the data:

Jonas Svensson

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Rotational Thromboelastometry predicts care level in Covid-19 Lou Almskog, Agneta Wikman, Jonas Svensson, Michael Wanecek, Matteo Bottai, Jan van der Linden, Anna Agren medRxiv 2020.06.11.20128710; doi: https://doi.org/10.1101/2020.06.11.20128710
DOI: 10.1101/2020.06.11.20128710

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License:

Creative Commons License

Rotational Thromboelastometry predicts care level in COVID-19

Suggested citation:

Lou Almskog, Anna Ågren. Karolinska Institutet (2020). Rotational Thromboelastometry predicts care level in COVID-19. Swedish National Data Service. Version 1. https://doi.org/10.5878/wh80-0w17

Creator/Principal investigator(s):

Lou Almskog - Karolinska Institutet, Department of Molecular Medicine and Surgery

Anna Ågren - Karolinska University Hospital / Danderyd Hospital, Coagulation Unit, Division of Hematology / Department of Clinical Sciences

Description:

Keywords:

Data format / data structure:

Numeric

Data collection:

Mode of collection: Measurements and tests

Time period(s) for data collection: 2020-05-08 — 2020-05-31

Source of the data: Biological samples

Variables:

12

Number of individuals/objects:

60

Published: 2020-08-24
Last updated: 2020-08-26