Screening Across the Lifespan Twin Study (SALT)

SND-ID: 2021-196

This study is part of the collection NEAR - National E-Infrastructure for Aging Research in Sweden

Creator/Principal investigator(s)

Patrik Magnusson - Karolinska Institutet, The Swedish Twin Registry orcid

Nancy Pedersen - Karolinska Institutet orcid

Description

The SALT study was initiated in 1998 and is a sub-study of the Swedish Twin Registry (STR) where a complete screening of all twins born 1958 or earlier were included (n=44 919). There are three sub-studies of the SALT study; 1) HARMONY (1998-2003), where SALT participants who were 65 years or above were screened for dementia. All twins who screened positive together with their co-twins, as well as cognitively intact controls went through a clinical examination (n=1 557); 2) TwinGene (2004-2008) where biological samples were collected from a subset of the SALT population (n=12 614); 3) SALTY (2009-2010), which included another subset of twins from the SALT study who were born between 1943 and 1958 (n=11 372). Data have been collected at three waves over a total of ten years for the older cohort (included in HARMONY) and 12 years for the younger cohort (included in SALTY).


The purpose of the SALT study was to screen all twins in Sweden born 1958 or earlier for the most common complex diseases, regardless of the status of their twin partner.

• In the SALT study, computer assisted telephone i

... Show more..

Language

English

Swedish

Research principal, contributors, and funding

Research principal

Karolinska Institutet

Funding

  • Funding agency: The Swedish Research Council rorId
  • Funding agency's reference number: 2017-00641; 2021-00180
Protection and ethical review

Data contains personal data

Yes

Sensitive personal data

Yes

Type of personal data

Pseudonymised data

Code key exists

Yes

Ethics Review

Other - Ref. 00-132

Forskningsetikkommittén vid Karolinska Institutet

Other - Ref. 97-051 (HARMONY)

Forskningsetikkommittén vid Karolinska Institutet

Other - Ref. 96-098

Forskningsetikkommittén vid Karolinska Institutet

Method and time period

Unit of analysis

Population

Swedish twins born 1958 or earlier

Study design

Observational study

Cohort study

Sampling procedure

Total universe/Complete enumeration
All twins born 1958 or earlier and alive in 1998.

Time period(s) investigated

1998 – 2010

Biobank is connected to the study

The study has collected samples/material which are stored in a scientific collection or biobank

Scientific collection or biobank name: SALT

Type(s) of sample: Blood tests

Geographic coverage

Geographic spread

Geographic location: Sweden

Publications

Zagai, U., Lichtenstein, P., Pedersen, N., & Magnusson, P. (2019). The Swedish Twin Registry: Content and Management as a Research Infrastructure. Twin Research and Human Genetics, 22(6), 672-680. doi:10.1017/thg.2019.99
DOI: https://doi.org/10.1017/thg.2019.99

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Dataset
Screening Across the Lifespan Twin Study (SALT)

Associated documentation

Description

The SALT study was initiated in 1998, with the purpose of screening all twins in Sweden born before 1958 for most common complex diseases, regardless of the status of their twin partner. The extensive interview included questions about illnesses and health, medication use, occupation, education, and lifestyle factors.

For more detailed information
https://neardb.near-aging.se/search#lists?type=variables&query=study(in(Mica_study.id,salt)),variable(limit(0,20))

Data format / data structure

Numeric

Creator/Principal investigator(s)

Patrik Magnusson - Karolinska Institutet, The Swedish Twin Registry orcid

Nancy Pedersen - Karolinska Institutet orcid

Data collection 1

  • Mode of collection: Interview
  • Time period(s) for data collection: 1998-01–2002

Data collection 2

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 1998-02–2003

Data collection 3

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 2004–2008
... Show more..

Variables

2186

Published: 2022-03-07
Last updated: 2022-03-07