Differences in metabolic profiles between the Burmese, the Maine Coon and the Birman cat - three breeds with varying risk for diabetes mellitus - Information on healthy cats of three breeds; Burmese, Birman and Maine coon. Data on the cats (e.g. age and weight) and on serum blood concentrations.

SND-ID: 2021-58-1. Version: 1. DOI: https://doi.org/10.5878/7qsz-6j80

Citation

Creator/Principal investigator(s)

Bodil Ström Holst - Swedish University of Agricultural Sciences, Department of Clinical Sciences orcid

Malin Öhlund - Medical Products Agency orcid

Ali Moazzami - Swedish University of Agricultural Sciences, Department of Molecular Sciences orcid

Elisabeth Mullner - Swedish University of Agricultural Sciences, Department of Molecular Sciences

Fredrick Anderson - Umeå university, Department of Medical Biosciences

Research principal

Swedish University of Agricultural Sciences - Department of Clinical Sciences rorId

Principal's reference number

SLU.kv.2016.4.1-160

Description

Feline diabetes mellitus shares many features with type 2 diabetes in people, regarding clinical presentation, physiology, and pathology. A breed predisposition for type 2 diabetes has been identified, with the Burmese breed at a fivefold increased risk of developing the condition compared to other purebred cats. We aimed to characterize the serum metabolome in cats (n = 63) using nuclear magnetic resonance metabolomics, and to compare the metabolite pattern of Burmese cats with that of two cat breeds of medium or low risk of diabetes, the Maine coon (MCO) and Birman cat, respectively. Serum concentrations of adiponectin, insulin and insulin-like growth factor-1 were also measured (n = 94). Burmese cats had higher insulin and lower adiponectin concentrations than MCO cats. Twenty one metabolites were discriminative between breeds using a multivariate statistical approach and 15 remained significant after adjustment for body weight and body condition score. Burmese cats had higher plasma levels of 2-hydroxybutyrate relative to MCO and Birman cats and increased concentrations of 2-oxoisocaproic

... Show more..
Feline diabetes mellitus shares many features with type 2 diabetes in people, regarding clinical presentation, physiology, and pathology. A breed predisposition for type 2 diabetes has been identified, with the Burmese breed at a fivefold increased risk of developing the condition compared to other purebred cats. We aimed to characterize the serum metabolome in cats (n = 63) using nuclear magnetic resonance metabolomics, and to compare the metabolite pattern of Burmese cats with that of two cat breeds of medium or low risk of diabetes, the Maine coon (MCO) and Birman cat, respectively. Serum concentrations of adiponectin, insulin and insulin-like growth factor-1 were also measured (n = 94). Burmese cats had higher insulin and lower adiponectin concentrations than MCO cats. Twenty one metabolites were discriminative between breeds using a multivariate statistical approach and 15 remained significant after adjustment for body weight and body condition score. Burmese cats had higher plasma levels of 2-hydroxybutyrate relative to MCO and Birman cats and increased concentrations of 2-oxoisocaproic acid, and tyrosine, and lower concentrations of dimethylglycine relative to MCO cats. The metabolic profile of MCO cats was characterized by high concentrations of arginine, asparagine, methionine, succinic acid and low levels of acetylcarnitine while Birman cats had the highest creatinine and the lowest taurine plasma levels, compared with MCO and Burmese. The pattern of metabolites in Burmese cats is similar to that in people with insulin resistance. In conclusion, the metabolic profile differed between healthy cats of three breeds. Detection of an abnormal metabolome might identify cats at risk of developing diabetes.
The study was approved by the ethics committee on animal experiments in Uppsala, reference number C 299/12 and C 12/15, and by the Swedish Board of Agriculture, reference number 31-11654/12.

Results from analysis of blood samples from healthy cats of three breeds: Burmese, Birman and Maine coon, are included. A clinical examination was performed on the cats and information noted. Hormones were analysed in serum using immunological methods. Lipoproteins were analysed using HPLC (high performance liquid chromatography) and metabolomics using NMR (nuclear magnetic resonance) spectroscopy. Show less..

Data contains personal data

No

Language

Method and outcome

Unit of analysis

Population

Cats of three breeds: Birman, Burmese and Maine Coon

Time Method

Sampling procedure

Time period(s) investigated

2013 – 2015

Variables

83

Response rate/participation rate

100%

Data format / data structure

Data collection
  • Time period(s) for data collection: 2013 – 2015
Geographic coverage

Geographic spread

Geographic location: Sweden

Administrative information

Responsible department/unit

Department of Clinical Sciences

Contributor(s)

Ulrika Hermansson - Swedish University of Agricultural Sciences, University Animal Hospital

Helene Hansson-Hamlin - Swedish Unversity of Agricultural Sciences, Department of Clinical Sciences

Ann Pettersson - Swedish University of Agricultural Sciences, Department of Clinical Sciences orcid

Jens Häggström - Swedish University of Agricultural Sciences, Department of Clinical Sciences orcid

Funding

  • Funding agency: Research Fund for Companion Animals at SLU
  • Funding agency's reference number: 221760000
  • Project name on the application: Diabetes hos katt- fokus på riskrasen Burma

Ethics Review

Uppsala

Topic and keywords

Research area

Plants and animals (CESSDA Topic Classification)

Clinical science (Standard för svensk indelning av forskningsämnen 2011)

Publications

Öhlund M, Müllner E, Moazzami A, Hermansson U, Pettersson A, Anderson F, Häggström J, Hansson-Hamlin H, Holst, BS (2021). Differences in metabolic profiles between the Burmese, the Maine coon and the Birman cat—Three breeds with varying risk for diabetes mellitus. PLoS ONE 16(4): e0249322
DOI: https://doi.org/10.1371/journal.pone.0249322

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Versions

Version 1. 2021-04-06

Version 1: 2021-04-06

DOI: https://doi.org/10.5878/7qsz-6j80

Contacts for questions about the data

Bodil Ström Holst

bodil.strom-holst@slu.se

Malin Öhlund

malin.ohlund@mpa.se

Published: 2021-04-06
Last updated: 2021-10-25