Functional development in children and youth with cerebral palsy in Uganda

SND-ID: 2021-68-1. Version: 1. DOI: https://doi.org/10.5878/txww-hg72

Citation

Alternative title

Functional development of Ugandan children/youth with CP

Creator/Principal investigator(s)

Angelina Kakooza-Mwesige - Makerere University Kampala Uganda, Pediatrics and Child Health orcid

Research principal

Karolinska Institutet - Womens and Children's Health rorId

Description

AIM
To follow the functional development of a population-based cohort of children and youth (C&Y) with cerebral palsy (CP) in rural Uganda and compare their development with developmental trajectories from high-income countries (HIC).

METHODS
Eighty-one C&Y aged 2–17 years with CP were assessed 2015 and 2019 using Gross Motor Function Measure-66 items (GMFM-66), Pediatric Evaluation of Disability Inventory, Ugandan version (PEDI-UG), and functional classification systems. We calculated scaled scores (actual scores) and reference scores (amount of deviation from HIC developmental trajectories). Wilcoxon signed rank test was used for statistical analyses.

RESULTS
C&Y with CP in Uganda exhibited no differences in scaled scores between the first and second assessments for GMFM-66 and PEDI-UG mobility skills, while they exhibited increased PEDI-UG self-care skills (p<0.001). Reference scores were more negative at the second assessment than at the first assessment for GMFM-66 (p=0.002) and PEDI-UG mobility (p=0.036) but not for PEDI-UG self-care. The increased difference in reference scores ove

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AIM
To follow the functional development of a population-based cohort of children and youth (C&Y) with cerebral palsy (CP) in rural Uganda and compare their development with developmental trajectories from high-income countries (HIC).

METHODS
Eighty-one C&Y aged 2–17 years with CP were assessed 2015 and 2019 using Gross Motor Function Measure-66 items (GMFM-66), Pediatric Evaluation of Disability Inventory, Ugandan version (PEDI-UG), and functional classification systems. We calculated scaled scores (actual scores) and reference scores (amount of deviation from HIC developmental trajectories). Wilcoxon signed rank test was used for statistical analyses.

RESULTS
C&Y with CP in Uganda exhibited no differences in scaled scores between the first and second assessments for GMFM-66 and PEDI-UG mobility skills, while they exhibited increased PEDI-UG self-care skills (p<0.001). Reference scores were more negative at the second assessment than at the first assessment for GMFM-66 (p=0.002) and PEDI-UG mobility (p=0.036) but not for PEDI-UG self-care. The increased difference in reference scores over the 4 years were primarily driven by younger children (2–5 years) and C&Y with milder impairments.

INTERPRETATION
The increased difference in reference scores between assessments suggests that C&Y with CP in Uganda develop motor skills at a lower rate than peers in HIC.

The dataset contains of the following files:
- Functional_development_in Uganda_dataset_Andrews_et_al.csv
- Variable_list_for_functional_development_in_Uganda_dataset_Andrews_et_al.pdf

Information about the tool Gross Motor Function Measure-66 (GMFM-66):
https://www.canchild.ca/en/resources/44-gross-motor-function-measure-gmfm Show less..

Data contains personal data

Yes

Sensitive personal data

Yes

Code key exists

Yes

Language

Method and outcome

Population

A population-based cohort of children with Cerebral Palsy in a geographically defined area in Eastern Uganda

Study design

Observational study

Time period(s) investigated

2015-04 – 2019-12

Variables

35

Number of individuals/objects

81

Data format / data structure

Data collection
  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 2015-04 – 2019-12
  • Source of the data: Research data, Population group
Geographic coverage

Geographic spread

Geographic location: Uganda, Sub-Saharan Africa

Geographic description: Iganga/Mayuge Health and Demographic Surveillance Site, Uganda

Administrative information

Responsible department/unit

Womens and Children's Health

Contributor(s)

Makerere University, Pediatrics and Child Health rorId

Funding

  • Funding agency: Swedish Ressearch council rorId

Ethics Review

Other - Ref. HS1787 & HS2608

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Neurology (Standard för svensk indelning av forskningsämnen 2011)

Pediatrics (Standard för svensk indelning av forskningsämnen 2011)

Public health, global health, social medicine and epidemiology (Standard för svensk indelning av forskningsämnen 2011)

Physiotherapy (Standard för svensk indelning av forskningsämnen 2011)

Publications

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Kakooza-Mwesige A, Andrews C, Peterson S, Wabwire Mangen F, Eliasson AC, Forssberg H. Prevalence of cerebral palsy in Uganda: a population-based study. Lancet Glob Health. 2017 Dec;5(12):e1275-e1282. doi: 10.1016/S2214-109X(17)30374-1.
DOI: https://doi.org/10.1016/S2214-109X(17)30374-1

Andrews, C., Namaganda, L., Eliasson, A.-C., Kakooza-Mwesige, A. and Forssberg, H. (2021), Functional development in children with cerebral palsy in Uganda: population-based longitudinal cohort study. Dev Med Child Neurol. https://doi.org/10.1111/dmcn.14996.
DOI: https://doi.org/10.1111/dmcn.14996

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Published: 2021-08-19