H85

Principal investigator(s):

Ingmar Skoog - University of Gothenburg, Institute of Neuroscience and Physiology

Abstract:

'H85' is one of the longitudinal studies from Gothenburg where representative populations of older people has been followed over a long period. (Information about the studies H70, 95+ and Kvinnoundersökningen KVUS can be found under the tab Related studies.) This is a multidisciplinary study of representative samples of 85-year olds in Göteborg, which started in 1985 and is jointly managed by the Departments of Psychiatry and Psychology. In 1986-87 all 85-year-olds born between July 1, 1901 and June 30, 1902 and registered for census purposes in Gothenburg, Sweden, were invited to take part in a health control. Half of them were also examined by a psychiatrist (n=494). Follow-up studies have been done at ages 88, 90, 92, 95, 97, 99, 100, 101, 102, 103, 104 and and the response rate has remained at 65-80%. Another cohort of 85-year-olds born July 1, 1923 till June 30, 1924 were examined from 2008 to 2010 (N = 572, response rate 60%). These will be followed up in the same way as 85-year-olds born in 1901-02. A new H85 study of the birth cohort born in 1930 is planned during 2015. The studies i

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Contact:

Ingmar Skoog

Principal organisation:

Available documentation:

Study number:

Principal investigator(s):

Ingmar Skoog - University of Gothenburg, Institute of Neuroscience and Physiology

Principal organisation:

Purpose:

To investigate the frequency of, and which factors that are associated with psychiatric and somatic diseases in a population 85 years old followed longitudinally.

Abstract:

'H85' is one of the longitudinal studies from Gothenburg where representative populations of older people has been followed over a long period. (Information about the studies H70, 95+ and Kvinnoundersökningen KVUS can be found under the tab Related studies.) This is a multidisciplinary study of representative samples of 85-year olds in Göteborg, which started in 1985 and is jointly managed by the Departments of Psychiatry and Psychology. In 1986-87 all 85-year-olds born between July 1, 1901 and June 30, 1902 and registered for census purposes in Gothenburg, Sweden, were invited to take part in a health control. Half of them were also examined by a psychiatrist (n=494). Follow-up studies have been done at ages 88, 90, 92, 95, 97, 99, 100, 101, 102, 103, 104 and and the response rate has remained at 65-80%. Another cohort of 85-year-olds born July 1, 1923 till June 30, 1924 were examined from 2008 to 2010 (N = 572, response rate 60%). These will be followed up in the same way as 85-year-olds born in 1901-02. A new H85 study of the birth cohort born in 1930 is planned during 2015. The studies i

... more

Time period(s) investigated:

1986 — ongoing

Geographic location:

Geographic description:

Gothenburg

Unit of analysis:

Universe/Population:

The population originally consisted of a representative sample of 85-year-old men and women born in 1901/1902 and living in Gothenburg 1986/1987.

Time Method/Study design:

Sampling procedure:

Probability: Systematic random
The study participants were mainly drawn as a representative, systematic sample from the population register.

Publications

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Nilsson L, Persson G, Skoog I. Unik Svensk undersökning i Göteborg 85-åringar positiva till sexundersökningar. Ottar 1988;113-118.

Skoog I, Steen B, Persson G, Nilsson L, Aevarsson O, Larsson L, Östling S. A 15-year longitudinal cross-sectional population study on sleep in the elderly. Facts and research in gerontology 1993;7:137-146.

Skoog I, Nilsson L, Landahl S, Steen B. Mental disorders and the use of psychotropic drugs in an 85-year-old urban population. Int Psychogeriatrics 1993;5:33-48.

Skoog I, Nilsson L, Palmertz B, Andreasson L-A, Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med 1993; 328:153-158

Skoog I, Nilsson L, Svanborg A. The authors reply: A population-based study of dementia in 85-year-olds. N Engl J Med 1993;329:363.

Skoog I. The prevalence of psychotic, depressive and anxiety syndromes in demented and non-demented 85-year-olds. Int J Geriatric Psychiatry 1993;8:247-253.

Hellström L, Milsom I, Ekelund P, Skoog I. The influence of dementia on the prevalence of urinary and faecal incontinence in 85-year old men and women. Archives of Gerontology and Geriatrics 1994;19:11-20.

Skoog I, Palmertz B, Andreasson L-A. The prevalence of white matter lesions on computed tomography of the brain in demented and non-demented 85-year-olds. J Geriatr Psychiatry Neurol 1994;7:169-175.

Skoog I, Andreasson L-A, Palmertz B, Lernfeldt B, Landahl S, Steen B, Svanborg A. Vascular factors and dementia in 85-year-olds. In: Bergener M, Brocklehurst JC, Finkel SI (eds). Aging, Health, and Healing. New York: Springer Publishing Company Inc 1995; 49-55.

Skoog I, Vanmechelen E, Andreasson L-A, Palmertz B, Davidsson P, Hesse C, Blennow K. A population-based study of tau protein and ubiquitin in cerebrospinal fluid in 85-year-olds: relation to severity of dementia and cerebral atrophy, but not to the apolipoprotein E4 allele. Neurodegeneration 1995;4:433-442.

Johansson C, Skoog I. A population-based study on the association between dementia and hip fractures in 85-year-olds. Aging Clin Exp Res 1996;8:189-196.

Skoog I, Aevarsson O, Beskow J, Larsson L, Palsson S, Waern M, Landahl S, Östling, S. Suicidal feelings in a population sample of non-demented 85-year-olds. Am J Psychiatry 1996;153:1015-1020.

Skoog I, Berg S, Johansson B, Palmertz B, Andreasson L-A. The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurol Scand 1996;93:142-148.

Skoog I. Sex and Swedish 85-year-olds. N Engl J Med 1996;334:1140-1141.

Skoog I, Hesse C, Fredman P, Andreasson L-A, Palmertz B, Blennow K. Apolipoprotein E in cerebrospinal fluid in 85-year-olds. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white-matter lesions. Arch Neurol 1997; 54: 267-272.

Aevarsson O, Svanborg A, Skoog I. Seven-year survival after age 85 years. Relation to Alzheimer disease and vascular dementia. Arch Neurol 1998;55:1226-1232.

Skoog I, Hesse C, Aevarsson O, Landahl S, Wahlström J, Fredman P, Blennow K. A population study of Apo E genotype at the age of 85: relation to dementia, cerebrovascular disease and mortality. J Neurol Neurosur Psychiatr 1998;64:37-43.

Skoog I, Wallin A, Fredman P, Hesse C, Aevarsson O, Karlsson I, Gottfries CG, Blennow K. A population-study on blood-brain barrier function in 85-year-olds. Relation to Alzheimer’s disease and vascular dementia. Neurology 1998;50:966-971.

Skoog I. Andresson L-A, Palmertz B, Landahl S, Lernfelt B. A population-based study on blood pressure and brain atrophy in 85-year-olds. Hypertension 1998; 32: 404-409.

Palsson S, Aevarsson O, Skoog I. Depression, cerebral atrophy, cognitive performance and incidence of dementia. Population study of 85-year-olds. Brit J Psychiatr 1999;174:249-253.

Palsson S, Johansson B, Berg S, Skoog I. A population study on the influence of depression on neuropsychological functioning in 85-year-olds. Acta Psychiatr Scand 2000;101:185-193.

Liebetrau M, Steen B, Skoog I. Stroke in 85-year-olds. Prevalence, incidence, risk factors and relation to mortality and dementia. Stroke 2003;34:2617-2622.

Skoog I, Davidsson P, Aevarsson O, Vanderstichele H, Vammechelen E, Blennow K. Cerebrospinal Fluid Beta-Amyloid 42 Is Reduced before the Onset of Sporadic Dementia: A Population-Based Study in 85-Year-Olds. Dement geriatr Cogn Disord 2003;15:169-176.

Liebetrau M, Steen B, Hamann GF, Skoog I. Silent and symptomatic infarcts on cranial computerized tomography in relation to dementia and mortality. A populationbased study in 85-year-olds. Stroke 2004;35:1816-1820.

Östling S, Johansson B, Skoog I. Cognitive test performance in relation to psychotic symptoms and paranoid ideation in non-demented 85-year-olds. Psychol Med 2004;34:443-450.

Sacuiu S, Sjögren M, Gustafson D, Skoog I. Prodromal cognitive signs of dementia in 85-year-olds using four sources of information. Neurology 2005;65:1894-1900.

Liebetrau M, Steen B, Skoog I. Depression as a risk factor for the incidence of first-ever stroke in 85-year-olds. Stroke 2008;39:1960-1965.

Olesen PJ, Guo X, Gustafson D, Börjesson-Hanson A, Sacuíu S, Eckerström C, Bigler ED, Skoog I. A population-based study on the influence of brain atrophy on 20-year survival after age 85. Neurology 2011;76(10):879-86

Östling S, Gustafson D, Blennow K, Börjesson-Hanson A, Waern M. Psychotic symptoms in a population-based sample of 85-year-old individuals with dementia. J Geriatr Psychiatry Neurol. 2011 Mar;24(1):3-8.

Skoog I. Mental disorders in the elderly. A population study in 85-year-olds. Thesis, University of Gothenburg, 1993.
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Dataset EXT 0204-001

H85, kohort 1: 85-year-olds born in 1901/02

Description:

At the baseline examination during 1986/87 all 85-year-olds born between July 1, 1901 and June 30, 1902 and living in Gothenburg were invited to a health examination. Half of them were also examined by a psychiatrist (n=494). Participants were followed up at age 88, 90, 92, 95, 97, 99, 100, 101, 102, 103, 104 and 105. The study surveys have been conducted in 1986/87, 1989, 1991, 1993, 1996, 1998, 2000, 2001, 2002, 2003, 2004, 2005 and 2006.

Collection methodology:

A representative, systematic sample of 85-year-olds was drawn from the population register by selecting those born between July 1, 1901 and June 30, 1902 on dates ending with 2, 5 or 8.

Dataset EXT 0204-002

H85, kohort 2: 85-year-olds born in 1923/24

Description:

Another cohort 85-year-olds born between July 1, 1923 and June 30, 1924 was invited to the study. At the baseline examination (2008-2010), 572 individuals participated, representing a response rate of 60 %. Participants were followed up at age 88 and 90. The study surveys have been conducted in 2008-2010, 2011 and 2013.

Dataset EXT 0204-003