The cohort of 60-year-old men and women

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s):

Ulf de Faire - Karolinska Institute, Institute of Environmental Medicine

Description:

The cohort of 60-year old men and women consists of every third man and woman residing in Stockholm county, who during one year (1997 01 07 - 1998 0630) reached the age of 60, and who subsequently was invited to a careful health control, including blood sampling, and completion of a questionnaire, etc (response rate 78 %). Blood samples and DNA were stored in -80 ?C freezers (4 freezers) both at Karolinska Hospital and the Karolinska Institutet. DNA has been extracted on all subjects and 4232 individuals participated at the health check-up. The predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD) is assessed through annual matching against available national registers. So far 408 incident CVD cases have been registered (up to 2010, on average 12 years of follow up). About 35 international original articles have been generated from the database. Analyses of baseline data indicate that a variety of metabolic disturbances go unrecognized in this age group, many of which are attributed to low levels of physical exercise and bad life-style habits. Through analyse

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Creator/Principal investigator(s):

Ulf de Faire - Karolinska Institute, Institute of Environmental Medicine

Identifiers:

SND-ID: EXT 0038

Purpose:

To assess the predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD).

Description:

The cohort of 60-year old men and women consists of every third man and woman residing in Stockholm county, who during one year (1997 01 07 - 1998 0630) reached the age of 60, and who subsequently was invited to a careful health control, including blood sampling, and completion of a questionnaire, etc (response rate 78 %). Blood samples and DNA were stored in -80 ?C freezers (4 freezers) both at Karolinska Hospital and the Karolinska Institutet. DNA has been extracted on all subjects and 4232 individuals participated at the health check-up. The predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD) is assessed through annual matching against available national registers. So far 408 incident CVD cases have been registered (up to 2010, on average 12 years of follow up). About 35 international original articles have been generated from the database. Analyses of baseline data indicate that a variety of metabolic disturbances go unrecognized in this age group, many of which are attributed to low levels of physical exercise and bad life-style habits. Through analyse

... Show more..

Time period(s) investigated:

1997-01-07 — 1998-06-30

Unit of analysis:

Population:

2193 women and 2039 men, living in Stockholm county and 60 years of age when included.

Sampling procedure:

Probability: Simple random
Annual match to national registers to obtain information about death and inpatient occasions for cardiovascular diseases

Funding:

Swedish Research Council —2007-7429

Contact person for questions about the data:

Ulf de Faire

Publications

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Rosell MS, Hellénius ML, de Faire UH, Johansson GK. "Associations between diet and the metabolic syndrome vary with the validity of dietary intake data." , Am J Clin Nutr, 2003;78:84-90

de Faire U, Su J, Hua X, Frostegård A, Halldin M, Hellenius ML, Wikström M, Dahlbom I, Grönlund H, Frostegård J. Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism. J Autoimmun. 2010 Mar;34(2):73-9.

If you have published anything based on these data, please notify us with a reference to your publication(s).

The cohort of 60 years old men and women

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 1997-01-07 — 1998-06-30

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1997-01-07 — 1998-06-30

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Number of individuals/objects:

4232

Response rate/participation rate:

78%