Creator/Principal investigator(s)
Ulf de Faire - Karolinska Institutet, Institute of Environmental Medicine
Description
The cohort of 60-year old men and women consists of every third man and woman residing in Stockholm county, who during one year (1997 01 07 - 1998 0630) reached the age of 60, and who subsequently was invited to a careful health control, including blood sampling, and completion of a questionnaire, etc (response rate 78 %). Blood samples and DNA were stored in -80 ?C freezers (4 freezers) both at Karolinska Hospital and the Karolinska Institutet. DNA has been extracted on all subjects and 4232 individuals participated at the health check-up. The predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD) is assessed through annual matching against available national registers. So far 408 incident CVD cases have been registered (up to 2010, on average 12 years of follow up). About 35 international original articles have been generated from the database. Analyses of baseline data indicate that a variety of metabolic disturbances go unrecognized in this age group, many of which are attributed to low levels of physical exercise and bad life-style habits. Through analyse
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Responsible department/unit
Institute of Environmental Medicine
Unit of analysis
Population
2193 women and 2039 men, living in Stockholm county and 60 years of age when included.
Sampling procedure
Time period(s) investigated
1997-01-07 – 1998-06-30
Research area
HEALTH
(CESSDA Topic Classification)
Medical and Health Sciences, Cardiac and Cardiovascular Systems
(The Swedish standard of fields of research 2011)
Keywords
aged, physical examination, blood specimen collection, life style, exercise, socioeconomic factors, drug therapy, risk factors, diet, medical history taking, workplace, biomarkers, dna, family, leisure activities, pregnancy, cardiovascular diseases, health, body weight, menstruation, environmental exposure, personality, smoking, self concept, social support, stress, psychological, heredity, scc, swedish cohort consortium (scc), cohorts.se
de Faire U, Su J, Hua X, Frostegård A, Halldin M, Hellenius ML, Wikström M, Dahlbom I, Grönlund H, Frostegård J. Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism. J Autoimmun. 2010 Mar;34(2):73-9.
Rosell MS, Hellénius ML, de Faire UH, Johansson GK. "Associations between diet and the metabolic syndrome vary with the validity of dietary intake data." , Am J Clin Nutr, 2003;78:84-90
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Contact
Ulf de Faire
Associated documentation
Data format / data structure
Numeric
Creator/Principal investigator(s)
Ulf de Faire - Karolinska Institutet, Institute of Environmental Medicine
Number of individuals/objects
4232
Response rate/participation rate
78%