The ADONIX study

Creator/Principal investigator(s):

Kjell Torén - University of Gothenburg, Department of Public Health and Community Medicine

Anna-Carin Olin - University of Gothenburg, Department of Public Health and Community Medicine

Description:

"ADONIX" is an acronyme for "Adult-onset asthma and nitric oxide" and is the collective name for the population study conducted by the Department of Occupational and Environmental Medicine, University of Gothenburg. 6685 randomly selected persons aged 25-75 years, have participated. The ADONIX study collaborates with the INTERGENE study and the PURE study, both at the University of Gothenburg.
The study examines the prevalence of airway inflammation using exhaled nitric oxide (NO) by putting this in relation to the concentration of small particulates in the air on the particular day the measurement was made and the days before. Air pollution data are imported from Gothenburg Environmental Administration and other municipalities in Västra Götaland. Measurement of nitric oxide in exhaled air may eventually become a good test to diagnose asthma or other lung disease. The subjects also do a lung function test (spirometry), and answer questions concerning background factors such as recent job, allergies, asthma and heredity, and the current exposure of different kinds of air pollution both indoors

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Creator/Principal investigator(s):

Kjell Torén - University of Gothenburg, Department of Public Health and Community Medicine

Anna-Carin Olin - University of Gothenburg, Department of Public Health and Community Medicine

Identifiers:

SND-ID: EXT 0041

Purpose:

The original primary aim was investigating whether increased fraction of exhaled nitric oxide (FENO) is associated with an increased risk for new-onset asthma. This has been extended to an overall aim to increase the understanding of the interactions between different risk factors and genetic susceptibility in the mechanisms and prognosis for asthma and chronic obstructive pulmonary disease (COPD), coronary heart diseases and stroke.

Description:

"ADONIX" is an acronyme for "Adult-onset asthma and nitric oxide" and is the collective name for the population study conducted by the Department of Occupational and Environmental Medicine, University of Gothenburg. 6685 randomly selected persons aged 25-75 years, have participated. The ADONIX study collaborates with the INTERGENE study and the PURE study, both at the University of Gothenburg.
The study examines the prevalence of airway inflammation using exhaled nitric oxide (NO) by putting this in relation to the concentration of small particulates in the air on the particular day the measurement was made and the days before. Air pollution data are imported from Gothenburg Environmental Administration and other municipalities in Västra Götaland. Measurement of nitric oxide in exhaled air may eventually become a good test to diagnose asthma or other lung disease. The subjects also do a lung function test (spirometry), and answer questions concerning background factors such as recent job, allergies, asthma and heredity, and the current exposure of different kinds of air pollution both indoors

... Show more..

Time period(s) investigated:

2001 — 2008

Geographic spread:

Geographic location: Sweden

Geographic description: Västra Götaland

Unit of analysis:

Population:

Women and men in the age 25-75 years

Time Method:

Sampling procedure:

Probability: Simple random

Contact person for questions about the data:

Kjell Torén

Related research data in SND's catalogue:

Publications

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Wallentin Guron C, Hartford M, Rosengren A, Thelle D, Wallentin I, Caidahl K. Usefulness of atrial size inequality as an indicator of abnormal left ventricular filling. Am J Cardiol. 2005 Jun 15;95(12):1448-52.

Hagg D, Englund MC, Jernas M, Schmidt C, Wiklund O, Hulten LM, Ohlsson BG, Carlsson LM, Carlsson B, Svensson PA. Oxidized LDL induces a coordinated up-regulation of the glutathione and thioredoxin systems in human macrophages. Atherosclerosis. 2006 Apr;185(2):282-9.

Wallentin Guron C, Bech-Hanssen O, Wikh R, Rosengren A, Hartford M, Caidahl K. The E/e filling index and right ventricular pressure in relation to applied international Doppler recommendations of left ventricular filling assessment. Eur J Echocardiogr. 2005 Dec;6(6):419-28.

Berggren U, Fahlke C, Aronsson E, Karanti A, Eriksson M, Blennow K, Thelle D, Zetterberg H, Balldin J. The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small. Alcohol Alcohol 2006 Sep-Oct;41(5):479-85. Epub 2006 Jun 2

Olin AC, Rosengren A, Thelle DS, Lissner L, Bake B, Toren K. Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample. Chest 2006 Nov;130(5):1319-25.

Hagg D, Sjoberg S, Hulten LM, Fagerberg B, Wiklund O, Rosengren A, Carlsson LM, Boren J, Svensson PA, Krettek A. Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop? Atherosclerosis. 2007 Feb;190(2):291-7.

The expression of NAD(P)H:Quinone Oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction. J Clin Endocrinol Metab 2007; 92: 2346-2352

Olin AC, Bake B, Torén K. Fraction of exhaled nitric oxide at 50 mL/s: reference values for adult lifelong never-smokers. Chest 2008; 133: 831-832

Jerlock M, Kjellgren KI, Gaston-Johansson F, Lissner L, Manhem K, Rosengren A, Welin C. Psychosocial profile in men and women with unexplained chest pain. A case-control study. J Intern Med 2008 Apr 4. [Epub ahead of print]

Janson-Fagring A, Kjellgren K, Rosengren A, Lissner L, Manhem K, Welin C. Depression, anxiety, stress, social interaction and health-related quality of life in men and women with unexplained chest pain. BMC Public Health. 2008 May 19;8(1):165. [Epub ahead of print]

Hägg DA, Jernås M, Wiklund O, Thelle DS, Fagerberg B, Eriksson P, Hamsten A, Olsson B, Carlsson B, Carlsson LM, Svensson PA. Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility genes. Int J Mol Med. 2008 Jun;21(6):697-704.

Berg CM, Lappas G, Strandhagen E, Wolk A, Torén K, Rosengren A, Aires N, Thelle DS, Lissner L. Food patterns and cardiovascular disease risk factors: The Swedish INTERGENE research program. Am J Clin Nutr 2008; 88: 289-297.

Berg C, Lappas G, Wolk A, Strandhagen E, Torén K, Rosengren A, Thelle D, Lissner L. Eating patterns and portion size associated with obesity in a Swedish population. Appetite 2008;52:21-6.

Hägg DA, Olson FJ, Kjelldahl J, Jernås M, Thelle DS, Carlsson LMS, Fagerberg B, Svensson PA. Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic plaques. Atherosclerosis 2009 Jun;204(2):e15-20.

Berg J, Björck L, Dudas K, Lappas G, Rosengren A. Symptoms of a first acute myocardial infarction in women and men. Gend Med. 2009 Sep;6(3):454-62.

Aminoff AK, Ledmyr H <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ledmyr%20H%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>, Thulin P, Lundell K, Nunez L, Strandhagen E, Murphy C, Lidberg U, Westerbacka J, Franco-Cereceda A, Liska J, Nielsen LB, Gåfvels M, Nastase Mannila M, Hamsten A, Yki-Järvinen H, Thelle D, Eriksson P, Borén J, Ehrenborg E. Allele-specific regulation of MTTP expression influences th

If you have published anything based on these data, please notify us with a reference to your publication(s).

Available documentation:

The ADONIX study

Description:

2490 of the participants are also part of the INTERGENE study

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 2001 — 2008

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2001 — 2008

Source of the data: Population group, Biological samples

Time period(s) investigated:

2001 — 2008

Variables:

319

Number of individuals/objects:

6685

Response rate/participation rate:

44%