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The Northern Sweden MONICA Study

SND-ID: EXT 0042

This study is part of the collection Swedish Diet Cohort Consortium (SDCC) , Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Description

The Northern Sweden MONICA Study started with the WHO MONICA Study in 1985. The purpose was to monitor trends in mortality and morbidity in cardiovascular disease and relate them to trends in risk factors. Since 1985 21,000 strictly validated stroke events and 18,000 myocardial infarctions have been included in two registers. During the same period, six population based surveys have been taking place, the latest in 2009. The participation rates have been 69-81%. Subjects donated samples to the Northern Sweden Biobank. After 25 years since the start of the study, participants are starting to suffer from stroke, infarctions and diabetes in a rapidly increasing rate. We have successfully matched the event registers with population survey data, thereby creating a cost-effective prospective study design for MI, stroke and diabetes. Data from the three data bases has been used in more than 85 original studies and 14 dissertations since 2007. Increasingly other fields have been explored such as infectious diseases, nutrion and enviromental toxins.

Purpose:

To study cardiovascular risk factors in th

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Research principal, contributors, and funding

Research principal

Umeå University

Responsible department/unit

Department of Public Health and Clinical Medicine

Protection and ethical review
Method and time period

Unit of analysis

Population

25-74 years old

Time Method

Sampling procedure

Probability: Stratified

Time period(s) investigated

1985 – ongoing

Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: Norrbotten and Västerbotten Counties

Lowest geographic unit

County (NUTS3)

Topic and keywords

Research area

HEALTH (CESSDA Topic Classification)
Social and Clinical Pharmacy, Endocrinology and Diabetes, Cardiac and Cardiovascular Systems, Health Sciences (The Swedish standard of fields of research 2011)

Keywords

blood pressure, epidemiologic studies, cohort studies, medicine, exercise, socioeconomic factors, emotions, risk factors, myocardial infarction, stroke, work, workload, fractures, bone, chest pain, marital status, diabetes mellitus, leisure activities, cardiovascular diseases, health status, hypertension, coffee, cholesterol, lung diseases, food habits, smoking, pain, tobacco, smokeless, social support, tobacco, education, quality of life, dairy products, food, unemployment, sedentary behavior, diabetes, sdcc, swedish cohort consortium (scc), emotional support, swedish diet cohort consortium (sdcc), cohorts.se

Publications

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Eriksson M, Holmgren L, Janlert U, Jansson JH, Lundblad D, Stegmayr B, Soderberg S, Eliasson M. Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986-2009. J Intern Med. 2010 Nov 3.

Isaksson R, Jansson J, Lundblad D, Näslund U, Zingmark K, Eliasson M. Better long-term survival in young and middle-aged women than in men after a first myocardial infarction between 1985 and 2006. An analysis of 8360 patients in the Northern Sweden MONICA Study. BMC Cardiovasc Disord 2011;11:1.

Lundblad D, Holmgren L, Jansson JH, Naslund U, Eliasson M. Gender differences in trends of acute myocardial infarction events: the Northern Sweden MONICA study 1985 - 2004. BMC Cardiovasc Disord. 2008;8:17.

Isaksson RM, Holmgren L, Lundblad D, Brulin C, Eliasson M. Time trends in symptoms and prehospital delay time in women vs. men with myocardial infarction over a 15-year period. The Northern Sweden MONICA Study. Eur J Cardiovasc Nurs. 2008 Jun;7(2):152-8.

Karvanen J, Silander K, Kee F, Tiret L, Salomaa V, Kuulasmaa K, Wiklund PG, Virtamo J, Saarela O, Perret C, Perola M, Peltonen L, Cambien F, Erdmann J, Samani NJ, Schunkert H, Evans A. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009 Apr;33(3):237-46.

Janunger T, Nilsson-Ardnor S, Wiklund PG, Lindgren P, Escher SA, Lackovic K, Nilsson AK, Stegmayr B, Asplund K, Holmberg D. A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33. Neurology. 2009 Nov 24;73(21):1767-73.

Lilja M, Rolandsson O, Shaw JE, Pauvaday V, Cameron AJ, Tuomilehto J, Alberti KG, Zimmet PZ, Soderberg S. Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk. Int J Obes (Lond). 2010 Feb 2.

Van Guelpen B, Hultdin J, Johansson I, Witthoft C, Weinehall L, Eliasson M, Hallmans G, Palmqvist R, Jansson JH, Winkvist A. Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function. J Intern Med. 2009 Feb 27.

Alssema M, Vistisen D, Heymans MW, Nijpels G, Glumer C, Zimmet PZ, Shaw JE, Eliasson M, Stehouwer CD, Tabak AG, Colagiuri S, Borch-Johnsen K, Dekker JM. The Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) update of the Finnish diabetes risk score for prediction of incident type 2 diabetes. Diabetologia. 2010 Dec 12.

Lilja M, Eliasson M, Stegmayr B, Olsson T, Soderberg S. Trends in obesity and its distribution: data from the Northern Sweden MONICA Survey, 1986-2004. Obesity (Silver Spring). 2008 May;16(5):1120-8.

Norlund S, Reuterwall C, Hoog J, Lindahl B, Janlert U, Birgander LS. Burnout, working conditions and gender--results from the northern Sweden MONICA Study. BMC Public Health. 2010;10:326.

Eliasson M, Jansson JH, Lundblad D, Näslund U. The disparity between long-term survival in patients with and without diabetes following a first myocardial infarction did not change between 1989 and 2006: an analysis of 6,776 patients in the Northern Sweden MONICA Study. Diabetologia. 2011 Oct;54(10):2538-43. Epub 2011 Jul 21.

Warensjo E, Jansson JH, Cederholm T, Boman K, Eliasson M, Hallmans G, Johansson I, Sjogren P. Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study. Am J Clin Nutr. 2010 Jul;92(1):194-202.

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Dataset 1
The Northern Sweden MONICA Study 1986

Associated documentation

Description

A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1986 study.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes

Time period(s) investigated

1985

Data collection 1

  • Mode of collection: Self-administered questionnaire: paper
  • Time period(s) for data collection: 1985
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Time period(s) for data collection: 1985
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1985
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Number of individuals/objects

1625

Response rate/participation rate

81%

Dataset 2
The Northern Sweden MONICA Study 1990

Associated documentation

Description

A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1990 study.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes

Time period(s) investigated

1990

Data collection 1

  • Time period(s) for data collection: 1990
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Mode of collection: Field observation
  • Time period(s) for data collection: 1990
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1990
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Number of individuals/objects

1583

Response rate/participation rate

79%

Dataset 3
The Northern Sweden MONICA Study 1994

Associated documentation

Description

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1994 study.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes

Time period(s) investigated

1994

Data collection 1

  • Mode of collection: Self-administered questionnaire: paper
  • Time period(s) for data collection: 1994
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Mode of collection: Field observation
  • Time period(s) for data collection: 1994
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Time period(s) for data collection: 1994
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Number of individuals/objects

1921

Response rate/participation rate

77%

Dataset 4
The Northern Sweden MONICA Study 1999

Associated documentation

Description

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1999 study.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes

Time period(s) investigated

1999

Data collection 1

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1999
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Mode of collection: Self-administered questionnaire: paper
  • Time period(s) for data collection: 1999
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Time period(s) for data collection: 1999
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Number of individuals/objects

1823

Response rate/participation rate

73%

Dataset 5
The Northern Sweden MONICA Study 2004

Associated documentation

Description

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1986 study.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes

Time period(s) investigated

2004

Data collection 1

  • Time period(s) for data collection: 2004
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Mode of collection: Field observation
  • Time period(s) for data collection: 2004
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Mode of collection: Self-administered questionnaire: paper
  • Time period(s) for data collection: 2004
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Number of individuals/objects

1905

Response rate/participation rate

76%

Dataset 6
The Northern Sweden MONICA Study 2009

Associated documentation

Description

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 2009 study.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes

Time period(s) investigated

2009

Data collection 1

  • Time period(s) for data collection: 2009
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Mode of collection: Field observation
  • Time period(s) for data collection: 2009
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Mode of collection: Self-administered questionnaire: paper
  • Time period(s) for data collection: 2009
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Number of individuals/objects

1729

Response rate/participation rate

69%

Dataset 7
The MONICA Myocardial Infarction Registry

Associated documentation

Description

Everyone who had a verified myocardial infarction in Norrbotten and Västerbotten in 1985. In 1985-1999 25-64 years-old were included, after that 25-74 years-old.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Number of individuals/objects

18000

Dataset 8
The MONICA Stroke Registry

Associated documentation

Description

People aged 25-74 years residing in Norrbotten or Västerbotten Counties who suffered a stroke has since 1985 been registered in the stroke registry.

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Number of individuals/objects

21000

Dataset 9
The Northern Sweden MONICA Study 2014

Associated documentation

Data format / data structure

Numeric

Creator/Principal investigator(s)

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Keywords

epidemiologic studies, cohort studies, socioeconomic factors, risk factors, myocardial infarction, stroke, diabetes mellitus

Data collection 1

  • Mode of collection: Field observation
  • Time period(s) for data collection: 2014
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Time period(s) for data collection: 2014
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2014
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples
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Response rate/participation rate

63%

Contact for questions about the data

Is part of collection at SND

Swedish Diet Cohort Consortium (SDCC)

Swedish Cohort Consortium (Cohorts.se)

Published: 2012-01-01
Last updated: 2017-03-08