The Northern Sweden MONICA Study

This study is part of the collection Swedish Cohort Consortium (Cohorts.se) , Swedish Diet Cohort Consortium (SDCC)

Creator/Principal investigator(s):

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Description:

The Northern Sweden MONICA Study started with the WHO MONICA Study in 1985. The purpose was to monitor trends in mortality and morbidity in cardiovascular disease and relate them to trends in risk factors. Since 1985 21,000 strictly validated stroke events and 18,000 myocardial infarctions have been included in two registers. During the same period, six population based surveys have been taking place, the latest in 2009. The participation rates have been 69-81%. Subjects donated samples to the Northern Sweden Biobank. After 25 years since the start of the study, participants are starting to suffer from stroke, infarctions and diabetes in a rapidly increasing rate. We have successfully matched the event registers with population survey data, thereby creating a cost-effective prospective study design for MI, stroke and diabetes. Data from the three data bases has been used in more than 85 original studies and 14 dissertations since 2007. Increasingly other fields have been explored such as infectious diseases, nutrion and enviromental toxins.

Creator/Principal investigator(s):

Stefan Söderberg - Umeå university, Department of Public Health and Clinical Medicine

Ann-Sofie Forslund - Norrbotten County Council, Department of Research

Identifiers:

SND-ID: EXT 0042

Purpose:

To study cardiovascular risk factors in the population and the incidence of myocardial infarction and stroke after strict validation.

Description:

The Northern Sweden MONICA Study started with the WHO MONICA Study in 1985. The purpose was to monitor trends in mortality and morbidity in cardiovascular disease and relate them to trends in risk factors. Since 1985 21,000 strictly validated stroke events and 18,000 myocardial infarctions have been included in two registers. During the same period, six population based surveys have been taking place, the latest in 2009. The participation rates have been 69-81%. Subjects donated samples to the Northern Sweden Biobank. After 25 years since the start of the study, participants are starting to suffer from stroke, infarctions and diabetes in a rapidly increasing rate. We have successfully matched the event registers with population survey data, thereby creating a cost-effective prospective study design for MI, stroke and diabetes. Data from the three data bases has been used in more than 85 original studies and 14 dissertations since 2007. Increasingly other fields have been explored such as infectious diseases, nutrion and enviromental toxins.

Time period(s) investigated:

1985 — ongoing

Geographic spread:

Geographic location: Sweden

Geographic description: Norrbotten and Västerbotten Counties

Lowest geographic unit:

County (NUTS3)

Unit of analysis:

Population:

25-74 years old

Sampling procedure:

Probability: Stratified

Data contains personal data:

Yes

Contact person for questions about the data:

Stefan Söderberg

Is part of collection at SND:

Swedish Cohort Consortium (Cohorts.se)

Swedish Diet Cohort Consortium (SDCC)

Publications

Sort by name | Sort by year

Eliasson M, Jansson JH, Lundblad D, Näslund U. The disparity between long-term survival in patients with and without diabetes following a first myocardial infarction did not change between 1989 and 2006: an analysis of 6,776 patients in the Northern Sweden MONICA Study. Diabetologia. 2011 Oct;54(10):2538-43. Epub 2011 Jul 21.

Isaksson R, Jansson J, Lundblad D, Näslund U, Zingmark K, Eliasson M. Better long-term survival in young and middle-aged women than in men after a first myocardial infarction between 1985 and 2006. An analysis of 8360 patients in the Northern Sweden MONICA Study. BMC Cardiovasc Disord 2011;11:1.

Warensjo E, Jansson JH, Cederholm T, Boman K, Eliasson M, Hallmans G, Johansson I, Sjogren P. Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study. Am J Clin Nutr. 2010 Jul;92(1):194-202.

Norlund S, Reuterwall C, Hoog J, Lindahl B, Janlert U, Birgander LS. Burnout, working conditions and gender--results from the northern Sweden MONICA Study. BMC Public Health. 2010;10:326.

Eriksson M, Holmgren L, Janlert U, Jansson JH, Lundblad D, Stegmayr B, Soderberg S, Eliasson M. Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986-2009. J Intern Med. 2010 Nov 3.

Lilja M, Rolandsson O, Shaw JE, Pauvaday V, Cameron AJ, Tuomilehto J, Alberti KG, Zimmet PZ, Soderberg S. Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk. Int J Obes (Lond). 2010 Feb 2.

Alssema M, Vistisen D, Heymans MW, Nijpels G, Glumer C, Zimmet PZ, Shaw JE, Eliasson M, Stehouwer CD, Tabak AG, Colagiuri S, Borch-Johnsen K, Dekker JM. The Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) update of the Finnish diabetes risk score for prediction of incident type 2 diabetes. Diabetologia. 2010 Dec 12.

Van Guelpen B, Hultdin J, Johansson I, Witthoft C, Weinehall L, Eliasson M, Hallmans G, Palmqvist R, Jansson JH, Winkvist A. Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function. J Intern Med. 2009 Feb 27.

Karvanen J, Silander K, Kee F, Tiret L, Salomaa V, Kuulasmaa K, Wiklund PG, Virtamo J, Saarela O, Perret C, Perola M, Peltonen L, Cambien F, Erdmann J, Samani NJ, Schunkert H, Evans A. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009 Apr;33(3):237-46.

Janunger T, Nilsson-Ardnor S, Wiklund PG, Lindgren P, Escher SA, Lackovic K, Nilsson AK, Stegmayr B, Asplund K, Holmberg D. A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33. Neurology. 2009 Nov 24;73(21):1767-73.

Lundblad D, Holmgren L, Jansson JH, Naslund U, Eliasson M. Gender differences in trends of acute myocardial infarction events: the Northern Sweden MONICA study 1985 - 2004. BMC Cardiovasc Disord. 2008;8:17.

Lilja M, Eliasson M, Stegmayr B, Olsson T, Soderberg S. Trends in obesity and its distribution: data from the Northern Sweden MONICA Survey, 1986-2004. Obesity (Silver Spring). 2008 May;16(5):1120-8.

Isaksson RM, Holmgren L, Lundblad D, Brulin C, Eliasson M. Time trends in symptoms and prehospital delay time in women vs. men with myocardial infarction over a 15-year period. The Northern Sweden MONICA Study. Eur J Cardiovasc Nurs. 2008 Jun;7(2):152-8.

Isaksson RM, Holmgren L, Lundblad D, Brulin C, Eliasson M. Time trends in symptoms and prehospital delay time in women vs. men with myocardial infarction over a 15-year period. The Northern Sweden MONICA Study. Eur J Cardiovasc Nurs. 2008 Jun;7(2):152-8.

If you have published anything based on these data, please notify us with a reference to your publication(s).

Dataset EXT 0042-001

The Northern Sweden MONICA Study 1986

Description:

A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1986 study.

Data format / data structure:

Numeric

Data collection:

Time period(s) for data collection: 1985

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Field observation

Time period(s) for data collection: 1985

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1985

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 1985

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) investigated:

1985

Number of individuals/objects:

1625

Response rate/participation rate:

81%

Dataset EXT 0042-002

The Northern Sweden MONICA Study 1990

Description:

A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1990 study.

Data format / data structure:

Numeric

Data collection:

Mode of collection: Field observation

Time period(s) for data collection: 1990

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1990

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) for data collection: 1990

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 1990

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) investigated:

1990

Number of individuals/objects:

1583

Response rate/participation rate:

79%

Dataset EXT 0042-003

The Northern Sweden MONICA Study 1994

Description:

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1994 study.

Data format / data structure:

Numeric

Data collection:

Mode of collection: Field observation

Time period(s) for data collection: 1994

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 1994

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) for data collection: 1994

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1994

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) investigated:

1994

Number of individuals/objects:

1921

Response rate/participation rate:

77%

Dataset EXT 0042-004

The Northern Sweden MONICA Study 1999

Description:

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1999 study.

Data format / data structure:

Numeric

Data collection:

Time period(s) for data collection: 1999

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Field observation

Time period(s) for data collection: 1999

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1999

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 1999

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) investigated:

1999

Number of individuals/objects:

1823

Response rate/participation rate:

73

Dataset EXT 0042-005

The Northern Sweden MONICA Study 2004

Description:

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1986 study.

Data format / data structure:

Numeric

Data collection:

Time period(s) for data collection: 2004

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 2004

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Field observation

Time period(s) for data collection: 2004

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2004

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) investigated:

2004

Number of individuals/objects:

1905

Response rate/participation rate:

76%

Dataset EXT 0042-006

The Northern Sweden MONICA Study 2009

Description:

A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 2009 study.

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 2009

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) for data collection: 2009

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Field observation

Time period(s) for data collection: 2009

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2009

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) investigated:

2009

Number of individuals/objects:

1729

Response rate/participation rate:

69%

Dataset EXT 0042-007

The MONICA Myocardial Infarction Registry

Description:

Everyone who had a verified myocardial infarction in Norrbotten and Västerbotten in 1985. In 1985-1999 25-64 years-old were included, after that 25-74 years-old.

Data format / data structure:

Numeric

Number of individuals/objects:

18000

Dataset EXT 0042-008

The MONICA Stroke Registry

Description:

People aged 25-74 years residing in Norrbotten or Västerbotten Counties who suffered a stroke has since 1985 been registered in the stroke registry.

Data format / data structure:

Numeric

Number of individuals/objects:

21000

Dataset EXT 0042-009

The Northern Sweden MONICA Study 2014

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire: paper

Time period(s) for data collection: 2014

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Time period(s) for data collection: 2014

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Field observation

Time period(s) for data collection: 2014

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2014

Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Response rate/participation rate:

63