Fertility and female dietary exposure to persistent organochlorine compounds

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Anna Axmon - Region Skåne, Occupational and Environmental Medicine

Lars Hagmar - Lunds universitet, Avdelningen för arbets- och miljömedicin, Institutionen för laboratoriemedicin

Ulf Strömberg - Lund University and Region Skåne, Department of Occupation and Environmental Medicine,Department of Laboratory Medicine and och Occupation and Environmental Medicine, Laboratory Medicine Skåne

Lars Rylander - Lund University and Region Skåne, Department of Occupation and Environmental Medicine,Department of Laboratory Medicine and och Occupation and Environmental Medicine, Laboratory Medicine Skåne

Description:

Animal studies have shown that exposure for PCBs, can effects the menstrual cycle and cause reduced fertility in females. In humans, fertility can be measured by examining the waiting time to pregnancy, ie the time between the time when a couple stop using contraception and the time when the woman becomes pregnant. This can be measured only if the pregnancy was planned. Once pregnancy has been established, it is possible to examine fetal survival by looking at miscarriage risk.
In Sweden consumption of fatty fish (such as salmon and herring) from the Baltic Sea is one of the major sources of exposure to PCB. It has previously been shown that Swedish fishermen and their families eats more fish than the general population.
In order to study the possible health effects of exposure to PCBs through consumption of fatty fish from the Baltic Sea, groups of fishermen from the Swedish east coast have been identified. By matching with different registers groups of wives and ex- wives of the fishermen (fishermen's wives), and groups of sisters and half-sisters (fish sisters) have been identified. As a

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Creator/Principal investigator(s):

Anna Axmon - Region Skåne, Occupational and Environmental Medicine

Lars Hagmar - Lunds universitet, Avdelningen för arbets- och miljömedicin, Institutionen för laboratoriemedicin

Ulf Strömberg - Lund University and Region Skåne, Department of Occupation and Environmental Medicine,Department of Laboratory Medicine and och Occupation and Environmental Medicine, Laboratory Medicine Skåne

Lars Rylander - Lund University and Region Skåne, Department of Occupation and Environmental Medicine,Department of Laboratory Medicine and och Occupation and Environmental Medicine, Laboratory Medicine Skåne

Identifiers:

SND-ID: EXT 0068

Purpose:

To investigate whether exposure to persistent organochlorine compounds through the consumption of fatty fish from the Baltic Sea leads to a decreased fertility, measured as time to pregnancy, to investigate whether the same exposure implies an increased miscarriage risk, and to assess the relation between blood levels of PCB and the reproductive outcomes time to pregnancy and miscarriages.

Description:

Animal studies have shown that exposure for PCBs, can effects the menstrual cycle and cause reduced fertility in females. In humans, fertility can be measured by examining the waiting time to pregnancy, ie the time between the time when a couple stop using contraception and the time when the woman becomes pregnant. This can be measured only if the pregnancy was planned. Once pregnancy has been established, it is possible to examine fetal survival by looking at miscarriage risk.
In Sweden consumption of fatty fish (such as salmon and herring) from the Baltic Sea is one of the major sources of exposure to PCB. It has previously been shown that Swedish fishermen and their families eats more fish than the general population.
In order to study the possible health effects of exposure to PCBs through consumption of fatty fish from the Baltic Sea, groups of fishermen from the Swedish east coast have been identified. By matching with different registers groups of wives and ex- wives of the fishermen (fishermen's wives), and groups of sisters and half-sisters (fish sisters) have been identified. As a

... Show more..

Time period(s) investigated:

1997 — 1999

Geographic spread:

Geographic description: The Swedish east and west coast

Unit of analysis:

Contact person for questions about the data:

Anna Axmon

Is part of collection at SND:

Scania Metadatabase for Epidemiology (SME)

Publications

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Axmon A, Rylander L, Rignell-Hydbom A. Reproductive toxicity of seafood contaminants: prospective comparisons of Swedish east and west coast fishermen's families. Environ Health. 2008 May 28;7:20. doi: 10.1186/1476-069X-7-20.

Axmon A. Menarche in women with high exposure to persistent organochlorine pollutants in utero and during childhood. Environ Res. 2006 Sep;102(1):77-82. Epub 2006 Feb 2.

Axmon A, Rignell-Hydbom A. Estimations of past male and female serum concentrations of biomarkers of persistent organochlorine pollutants and their impact on fecundability estimates. Environ Res. 2006 Jul;101(3):387-94. Epub 2005 Dec 13.

Axmon A, Rignell-Hydbom A. Association between biomarkers of exposure to persistent organochlorine compounds (POCs). Chemosphere. 2006 Jul;64(4):692-4. Epub 2005 Dec 9.

Axmon A, Hagmar L. Time to pregnancy and pregnancy outcome. Fertil Steril. 2005 Oct;84(4):966-74.

Axmon A, Rylander L, Strömberg U, Jönsson B, Nilsson-Ehle P, Hagmar L. Polychlorinated biphenyls in serum and time to pregnancy. Environ Res. 2004 Oct;96(2):186-95.

Axmon A, Rylander L, Strömberg U, Hagmar L. Altered menstrual cycles in women with a high dietary intake of persistent organochlorine compounds. Chemosphere. 2004 Aug;56(8):813-9.

Axmon A, Rylander L, Strömberg U, Hagmar L. Female fertility in relation to the consumption of fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health. 2002 Apr;28(2):124-32.

Axmon A, Rylander L, Strömberg U, Dyremark E, Hagmar L. Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to time to pregnancy. J Toxicol Environ Health A. 2001 Nov 23;64(6):485-98.

Axmon A, Rylander L, Strömberg U, Hagmar L. Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health. 2000 Jun;26(3):199-206.

Axmon A, Rylander L, Strömberg U, Hagmar L. Miscarriages and stillbirths in women with a high intake of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health. 2000 Apr;73(3):204-8.

If you have published anything based on these data, please notify us with a reference to your publication(s).

Dataset EXT 0068-001

The fishermen’s wives

Description:

For each woman’s five first pregnancies, information was collected on the use of contraceptives prior the pregnancy, time to pregnancy for those pregnancies that where planned, pregnancy outcome, and whether the pregnancy was a result of any medical treatment or a birth control failure. Working situation (working/not working, full/part time, shift work and night work) and heavy lifting was asked about for the woman, whereas smoking habits and coffee consumption was assessed for both the woman an

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Data format / data structure:

Numeric

Data collection:

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1997 — 1997

Source of the data: Population group

Time period(s) investigated:

1997 — 1997

Number of individuals/objects:

1595

Response rate/participation rate:

60%

Dataset EXT 0068-002

The fishermen’s sisters

Description:

Here, only the first planned pregnancy of each woman was inquired about. The questions asked in the sister questionnaire were similar to those in the wife questionnaire. No information was collected on the women’s partners. The fishermen’s sisters were asked about their alcohol consumption, and if they at any point in their life had experienced a miscarriage. Of the 709 east coast fishermen’s sisters who replied to the first questionnaire, 203 women supplied a time to pregnancy as well as agreed

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Data format / data structure:

Numeric

Data collection:

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1999 — 1999

Source of the data: Population group

Time period(s) investigated:

1999 — 1999

Number of individuals/objects:

1812

Response rate/participation rate:

58%