The Environmental Determinants of Diabetes in the Young - TEDDY

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Åke Lernmark - Lunds universitet

Description:

Umbilical cord blood was taken from 48000 new born children in the county of Skåne in order to determine the risk of hereditary type 1 diabetes. Of the screened children 7,4% had an increased risk. Of these, 2,525 children participate in the study follow-up part. TEDDY children will be followed until they are 15 years old. Up until 4 years of age, the child visits a TEDDY office every 3 months. After 4 years of age, the visits takes place two times per year. If the child shows signs of an autoimmune process started, that the child has acquired antibodies in the blood, the child are followed-up every three months in the future. The study includes blood, feaces, urine and saliva samples as well as samples from the nails. Height and weight are recorded and children's physical activity is measured. Food Diary conducted during periods and sample on the family's tap water is taken. Further interviews are conducted and the parents respond to different questionnaires.

Subject area:

HEALTH (CESSDA Topic Classification)
Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes (The Swedish standard of fields of research 2011)

Keywords:

children, Insulin, ambient exposure, Scania, EpiHealth, Diabetes Mellitus, Type 1, GAD65, IA-2, ZnT8, viral infections, EpiHealth_Skåne

Principal organisation:

Lund University

Accessibility status:

Access to data through an external actor
Access to data is restricted

Homepage:

The study homepage

Responsible department/unit:

Creator/Principal investigator(s):

Åke Lernmark - Lunds universitet

Identifiers:

SND-ID: EXT 0080

Purpose:

To identify environmental exposures that are associated with increased risk of developing autoantibodies against pancreatic islet beta cells in children. Children who develop two or more islet cell autoantibodies develop type 1 diabetes, which may take months or years. The secondary aim is to study the mechanisms behind why some children that developed two or more islet cell autoantibodies eventually develop diabetes.

Description:

Umbilical cord blood was taken from 48000 new born children in the county of Skåne in order to determine the risk of hereditary type 1 diabetes. Of the screened children 7,4% had an increased risk. Of these, 2,525 children participate in the study follow-up part. TEDDY children will be followed until they are 15 years old. Up until 4 years of age, the child visits a TEDDY office every 3 months. After 4 years of age, the visits takes place two times per year. If the child shows signs of an autoimmune process started, that the child has acquired antibodies in the blood, the child are followed-up every three months in the future. The study includes blood, feaces, urine and saliva samples as well as samples from the nails. Height and weight are recorded and children's physical activity is measured. Food Diary conducted during periods and sample on the family's tap water is taken. Further interviews are conducted and the parents respond to different questionnaires.

Time period(s) investigated:

2004-09 — ongoing

Geographic spread:

Geographic description: Scania (5 additional centres in USA,Finland and Germany)

Unit of analysis:

Subject area:

HEALTH (CESSDA Topic Classification)
Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes (The Swedish standard of fields of research 2011)

Keywords:

children, Insulin, ambient exposure, Scania, EpiHealth, Diabetes Mellitus, Type 1, GAD65, IA-2, ZnT8, viral infections, EpiHealth_Skåne

Contact person for questions about the data:

Åke Lernmark

Is part of collection at SND:

Scania Metadatabase for Epidemiology (SME)

Available documentation:

TEDDY Protocol (Swedish)

rsrapport 2011.pdf (Swedish)

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Dataset EXT 0080- 001

TEDDY: selection study

Data format / data structure:

Numeric

Data collection:

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2004-09 — 2010-02

Source of the data: Population group, Biological samples

Time period(s) investigated:

2004-09 — 2010-02

Number of individuals/objects:

48000

Dataset EXT 0080-002

TEDDY: follow up study

Data format / data structure:

Numeric

Number of individuals/objects:

2525