Risk factor study in young women of high risk for breast or ovarian cancer

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Helena Jernström - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Description:

Participants in this cohort are women identified from medical records and family records from the Department of Oncology , Lund. The inclusion criteria is that the woman should belong to families with a high risk of developing breast cancer as well as being known carriers of mutations in BRCA1 or BRCA2, or be related in the first or second generation to an individual with breast cancer or individual without breast cancer who are carriers of mutations in the genes BRCA1 or BRCA2. Study participants must be under 40 years old and still be menstruating.

“A family at high-risk for breast cancer” is considered if three women had been diagnosed with breast cancer and at least one of these was below age 50 years at diagnosis, or if two women had been diagnosed with breast cancer and at least one was below age 40 years at diagnosis, or if one woman diagnosed with breast cancer prior to age 30 years.


The collection, which is still ongoing, started in 1996 and consisted of 300 cases in 2010.

The selected women were contacted with a letter with information about the study and thereafter called and a

... Show more..

Responsible department/unit:

Creator/Principal investigator(s):

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Helena Jernström - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Identifiers:

SND-ID: EXT 0105

Purpose:

To study risk factors in young women of high risk for breast and ovarian cancer.

Description:

Participants in this cohort are women identified from medical records and family records from the Department of Oncology , Lund. The inclusion criteria is that the woman should belong to families with a high risk of developing breast cancer as well as being known carriers of mutations in BRCA1 or BRCA2, or be related in the first or second generation to an individual with breast cancer or individual without breast cancer who are carriers of mutations in the genes BRCA1 or BRCA2. Study participants must be under 40 years old and still be menstruating.

“A family at high-risk for breast cancer” is considered if three women had been diagnosed with breast cancer and at least one of these was below age 50 years at diagnosis, or if two women had been diagnosed with breast cancer and at least one was below age 40 years at diagnosis, or if one woman diagnosed with breast cancer prior to age 30 years.


The collection, which is still ongoing, started in 1996 and consisted of 300 cases in 2010.

The selected women were contacted with a letter with information about the study and thereafter called and a

... Show more..

Time period(s) investigated:

1993 — ongoing

Unit of analysis:

Population:

Women at high risk for breast cancer identified from records at the oncology clinic in Lund.

Time Method:

Sampling procedure:

Non-probability: Purposive

Contact persons for questions about the data:

Håkan Olsson

Helena Jernström

Is part of collection at SND:

Scania Metadatabase for Epidemiology (SME)

Publications

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Hietala M, Olsson H, Jernström H. Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk. Fam Cancer. 2008;7(3):221-8.

Henningson M, Hietala M, Törngren T, Olsson H, Jernström H. IGF1 htSNPs in relation to IGF-1 levels in young women from high-risk breast cancer families: implications for early-onset breast cancer. Fam Cancer. 2011 Jun;10(2):173-85. doi: 10.1007/s10689-010-9404-z.

If you have published anything based on these data, please notify us with a reference to your publication(s).

Women of high risk for breast and ovarian cancer

Description:

Data collection is ongoing. In 2010, the study consisted of 300 cases.

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1996

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1996

Source of the data: Population group, Biological samples

Time period(s) investigated:

1993 — ongoing

Number of individuals/objects:

300