Breast Cancer-metastases study

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Description:

The participants in this cohort are individuals with breast cancer and metastatic disease coming to the Department of Oncology in Lund for treatment since 2003. The data collection in the study is still ongoing. From all individuals, there is information about the status of the primary tumor, metastatic sites, tumor volume, and treatments. There are also paraffin-embedded tissue from primary tumor saved from all individuals, and for a subset of the cohort also frozen primary tumor tissue saved. There is DNA, plasma and serum saved from all individuals.

Creator/Principal investigator(s):

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Identifiers:

SND-ID: EXT 0122

Purpose:

To find tumor markers or tumor cells in the blood from patients with metastatic breast cancer.

Description:

The participants in this cohort are individuals with breast cancer and metastatic disease coming to the Department of Oncology in Lund for treatment since 2003. The data collection in the study is still ongoing. From all individuals, there is information about the status of the primary tumor, metastatic sites, tumor volume, and treatments. There are also paraffin-embedded tissue from primary tumor saved from all individuals, and for a subset of the cohort also frozen primary tumor tissue saved. There is DNA, plasma and serum saved from all individuals.

Time period(s) investigated:

2003 — ongoing

Unit of analysis:

Population:

Individuals with metastatic breast cancer, treated at the oncologist in Lund.

Time Method:

Sampling procedure:

Probability

Contact person for questions about the data:

Håkan Olsson

Is part of collection at SND:

Scania Metadatabase for Epidemiology (SME)

Publications

Sort by name | Sort by year

Carlsson A, Wingren C, Ingvarsson J, Ellmark P, Baldertorp B, Fernö M, Olsson H, Borrebaeck CA. Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays. Eur J Cancer. 2008 Feb;44(3):472-80. doi: 10.1016/j.ejca.2007.11.025. Epub 2008 Jan 2.

Carlsson MC, Balog CI, Kilsgård O, Hellmark T, Bakoush O, Segelmark M, Fernö M, Olsson H, Malmström J, Wuhrer M, Leffler H. Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease. Biochim Biophys Acta. 2012 Sep;1820(9):1366-72. doi: 10.1016/j.bbagen.2012.01.007. Epub 2012 Jan 17.

Carlsson MC, Cederfur C, Schaar V, Balog CI, Lepur A, Touret F, Salomonsson E, Deelder AM, Fernö M, Olsson H, Wuhrer M, Leffler H. Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One. 2011;6(10):e26560. doi: 10.1371/journal.pone.0026560. Epub 2011 Oct 18.
Read full text

Carlsson A, Wingren C, Kristensson M, Rose C, Fernö M, Olsson H, Jernström H, Ek S, Gustavsson E, Ingvar C, Ohlsson M, Peterson C, Borrebaecka C A.K. Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Proc Natl Acad Sci U S A. Aug 23, 2011; 108(34): 14252-14257. doi: 10.1073/pnas.1103125108. Published online Aug 15, 2011.
Read full text

If you have published anything based on these data, please notify us with a reference to your publication(s).

Individuals with a metastatic breast cancer

Description:

Data collection was started in 2003 and is ongoing (in 2010 there were over 300 individuals included in the study).

Data format / data structure:

Numeric

Data collection:

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2003

Source of the data: Registers/Records/Accounts: Administrative, Biological samples

Number of individuals/objects:

310