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Breast Cancer-metastases study

SND-ID: EXT 0122

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s)

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Description

The participants in this cohort are individuals with breast cancer and metastatic disease coming to the Department of Oncology in Lund for treatment since 2003. The data collection in the study is still ongoing. From all individuals, there is information about the status of the primary tumor, metastatic sites, tumor volume, and treatments. There are also paraffin-embedded tissue from primary tumor saved from all individuals, and for a subset of the cohort also frozen primary tumor tissue saved. There is DNA, plasma and serum saved from all individuals.

Purpose:

To find tumor markers or tumor cells in the blood from patients with metastatic breast cancer.
Research principal, contributors, and funding

Research principal

Region Skåne

Responsible department/unit

Faculty of Medicine, The Division of Oncology and Pathology

Protection and ethical review
Method and time period

Unit of analysis

Population

Individuals with metastatic breast cancer, treated at the oncologist in Lund.

Time Method

Sampling procedure

Probability

Time period(s) investigated

2003 – ongoing

Geographic coverage
Topic and keywords

Research area

HEALTH (CESSDA Topic Classification)
Clinical Medicine, Cancer and Oncology (The Swedish standard of fields of research 2011)

Keywords

cancer, blood specimen collection, neoplasms, biomarkers, breast neoplasms, dna, serum, biomarkers, tumor, plasma, paraffin embedding, tissue embedding, scania, frozen tissue, epihealth, epihealth_skåne

Publications

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Carlsson MC, Cederfur C, Schaar V, Balog CI, Lepur A, Touret F, Salomonsson E, Deelder AM, Fernö M, Olsson H, Wuhrer M, Leffler H. Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One. 2011;6(10):e26560. doi: 10.1371/journal.pone.0026560. Epub 2011 Oct 18.
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Carlsson A, Wingren C, Kristensson M, Rose C, Fernö M, Olsson H, Jernström H, Ek S, Gustavsson E, Ingvar C, Ohlsson M, Peterson C, Borrebaecka C A.K. Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Proc Natl Acad Sci U S A. Aug 23, 2011; 108(34): 14252-14257. doi: 10.1073/pnas.1103125108. Published online Aug 15, 2011.
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Carlsson A, Wingren C, Ingvarsson J, Ellmark P, Baldertorp B, Fernö M, Olsson H, Borrebaeck CA. Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays. Eur J Cancer. 2008 Feb;44(3):472-80. doi: 10.1016/j.ejca.2007.11.025. Epub 2008 Jan 2.

Carlsson MC, Balog CI, Kilsgård O, Hellmark T, Bakoush O, Segelmark M, Fernö M, Olsson H, Malmström J, Wuhrer M, Leffler H. Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease. Biochim Biophys Acta. 2012 Sep;1820(9):1366-72. doi: 10.1016/j.bbagen.2012.01.007. Epub 2012 Jan 17.

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Dataset
Individuals with a metastatic breast cancer

Description

Data collection was started in 2003 and is ongoing (in 2010 there were over 300 individuals included in the study).

Data format / data structure

Numeric

Creator/Principal investigator(s)

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Data collection

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2003–ongoing
  • Source of the data: Registers/Records/Accounts: Administrative, Biological samples

Number of individuals/objects

310

Contact for questions about the data

Is part of collection at SND

Scania Metadatabase for Epidemiology (SME)

Published: 2014-09-05
Last updated: 2017-03-21