Family studies of pediatric cancer

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Description:

In this unique Swedish study, which started in September 2008, all new and prevalent cancer cases in southern Sweden are included to create a family history data bank. All children ≤18 years of age with a malignant disease in the Southern Swedish Health Care Region (approximately 1.8 million inhabitants) are referred for care to the Department of Pediatrics at the Skåne University Hospital in Lund. Patients with a newly diagnosed malignancy and patients visiting the clinics for follow-up after completed treatment were invited to participate in the study. The eligibility criteria include (a) a diagnosis before 19 years of age with a malignancy following codes ICD 140 to 209 and (b) a diagnosis after 1970. Blood samples are collected and the patients and their parents are requested to complete a self-reported questionnaire, assessing name, date of birth, date of death, and history of cancer among first-, second- and third degree relatives. In addition a question about cancer in more distant relatives is included. Information regarding specific type of cancer and date of, or age at, diagnosis for

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Creator/Principal investigator(s):

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Identifiers:

SND-ID: EXT 0123

Purpose:

The aim is to create a family history data bank with DNA of all new cases of pediatric cancer, to enable gene studies.

Description:

In this unique Swedish study, which started in September 2008, all new and prevalent cancer cases in southern Sweden are included to create a family history data bank. All children ≤18 years of age with a malignant disease in the Southern Swedish Health Care Region (approximately 1.8 million inhabitants) are referred for care to the Department of Pediatrics at the Skåne University Hospital in Lund. Patients with a newly diagnosed malignancy and patients visiting the clinics for follow-up after completed treatment were invited to participate in the study. The eligibility criteria include (a) a diagnosis before 19 years of age with a malignancy following codes ICD 140 to 209 and (b) a diagnosis after 1970. Blood samples are collected and the patients and their parents are requested to complete a self-reported questionnaire, assessing name, date of birth, date of death, and history of cancer among first-, second- and third degree relatives. In addition a question about cancer in more distant relatives is included. Information regarding specific type of cancer and date of, or age at, diagnosis for

... Show more..

Time period(s) investigated:

2008-09 — ongoing

Unit of analysis:

Population:

All new and prevalent cases of cancer among children in the Southern Swedish Health Care Region.

Time Method:

Sampling procedure:

Non-probability

Contact person for questions about the data:

Håkan Olsson

Is part of collection at SND:

Scania Metadatabase for Epidemiology (SME)

Publications

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Magnusson S, Wiebe T, Kristoffersson U, Jernström H, Olsson H. Increased incidence of childhood, prostate and breast cancers in relatives of childhood cancer patients. Fam Cancer. 2012 Mar;11(1):145-55. doi: 10.1007/s10689-011-9493-3.

If you have published anything based on these data, please notify us with a reference to your publication(s).

Family history data bank

Description:

Family history data bank, based on all new and prevalent cancer cases in the Southern Swedish Health Care Region. Until 2014 there were 650 children included in the study, and blood from 125 parents. The response rate is between 30-40%.

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 2008-09

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2008-09

Source of the data: Population group, Biological samples

Response rate/participation rate:

ca 30- 40 %