BIG3

This study is part of the collection Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Ulf Malmqvist - Region Skåne

Description:

BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden.
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.

Ultimately, the study aims to find out which individuals that are at greater risk of develo

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Responsible department/unit:

Creator/Principal investigator(s):

Ulf Malmqvist - Region Skåne

Identifiers:

SND-ID: EXT 0129

Purpose:

BIG3 aims to increase understanding and to reduce morbidity / mortality in chronic diseases such as COPD, lung cancer and cardiovascular diseases, and to improve the care and quality of life for individuals with these disorders.

Description:

BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden.
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.

Ultimately, the study aims to find out which individuals that are at greater risk of develo

... Show more..

Time period(s) investigated:

2013 — ongoing

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 2013

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2013

Source of the data: Population group, Biological samples

Unit of analysis:

Population:

100 000 individuals between 45-77 years, residing in Scania.

Sampling procedure:

Probability

Ethics Review:

Lund —2011/371, 2012474, 2013/350, 2013/856 samt 2014/535

Biobank is connected to the study:

Yes

Contact person for questions about the data:

Ulf Malmqvist

Is part of collection at SND:

Scania Metadatabase for Epidemiology (SME)

Dataset EXT 0129-001

Survey

Description:

As a first step, around 100,000 individuals between 45 and 75 years and living in Scania have the opportunity to answer a questionnaire about lifestyle and health. Until September 2014, the number of respondents to the questionnaire was about 3000.

Data format / data structure:

Numeric

Time period(s) investigated:

2013 — ongoing

Dataset EXT 0129-002

Examination

Description:

In the second stage, approximately 10 000 individuals of those submitted the questionnaire, are randomly invited to an examination at Skåne University Hospital. Until September 2014, approximately 1000 individuals completed an examination.

Data format / data structure:

Numeric

Time period(s) investigated:

2013 — ongoing