Creator/Principal investigator(s)
Ulf Malmqvist - Region Skåne
Description
BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden.
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.
Ultimately, the study aims to find out which individuals that are at greater risk of develo
Research principal
Ethics Review
Lund - Ref. 2011/371, 2012474, 2013/350, 2013/856 samt 2014/535
Unit of analysis
Population
100 000 individuals between 45-77 years, residing in Scania.
Time Method
Sampling procedure
Time period(s) investigated
2013 – ongoing
Biobank is connected to the study
Yes
Research area
HEALTH
(CESSDA Topic Classification)
Medical and Health Sciences, Clinical Medicine, Cancer and Oncology, Cardiac and Cardiovascular Systems
(The Swedish standard of fields of research 2011)
Keywords
dental health, smoking, sleep, pregnancy, cardiovascular diseases, cancer, medical history, anthropometry, blood specimen collection, life style, memory, longitudinal studies, prospective studies, myocardial infarction, alcohol drinking, respiratory system, cardiovascular diseases, health status, body weight, lung neoplasms, lung diseases, menstruation, social support, respiratory tract diseases, social networks, epihealth, epihealth_skåne, scania, work environment
Description
As a first step, around 100,000 individuals between 45 and 75 years and living in Scania have the opportunity to answer a questionnaire about lifestyle and health. Until September 2014, the number of respondents to the questionnaire was about 3000.Data format / data structure
Numeric
Creator/Principal investigator(s)
Ulf Malmqvist - Region Skåne
Time period(s) investigated
2013 – ongoing
Description
In the second stage, approximately 10 000 individuals of those submitted the questionnaire, are randomly invited to an examination at Skåne University Hospital. Until September 2014, approximately 1000 individuals completed an examination.Data format / data structure
Numeric
Creator/Principal investigator(s)
Ulf Malmqvist - Region Skåne
Time period(s) investigated
2013 – ongoing