DIWA - Diabetes and Impaired glucose tolerance in Women and Atherosclerosis development study

Overview Description Data and documentation

Creator/Principal investigator(s)

Göran Bergström - University of Gothenburg, The Sahlgrenska Academy, Institute of Medicine

Description

All 64-year old women in the county of Gothenburg were invited to a screening examination including an OGTT. Glucose tolerance was defined for each participant according to the World Health Organization (WHO) criteria. Patients were divided in three sub-groups according to metabolic status and a randomized sample of patients were recruited from each group for a longitudinal follow-up study: diabetes mellitus (n = 220), impaired glucose tolerance (IGT, n = 204) or normal glucose tolerance (NGT, n = 188). Baseline examination was performed between 2002-2004 and follow-up examination in 2007-2009 (mean follow-up 5.5 years).
Datasets from papers published in open access is made available on request.

Purpose:

The aim of the DIWA-study is to investigate the development of atherosclerosis in women with different degrees of glucose control.

Subject area

HEALTH (CESSDA Topic Classification)
Endocrinology and Diabetes (The Swedish standard of fields of research 2011)

Keywords

longitudinal studies, glucose tolerance test, women, atherosclerosis, glucose, mass screening, diabetes mellitus, type 2, metabolic status

Principal organisation

University of Gothenburg

Accessibility status

Access to data through an external actor
Access to data is restricted

Homepage

The study homepage

Responsible department/unit

University of Gothenburg, Institute of Medicine

Creator/Principal investigator(s)

Göran Bergström - University of Gothenburg, The Sahlgrenska Academy, Institute of Medicine

Identifiers

SND-ID: EXT 0140

Description

Time period(s) investigated

2002 — ongoing

Geographic spread

Geographic description: Gothenburg

Unit of analysis

Individual

Population

64-year old women in Gothenburg (2002)

Time Method

Longitudinal: Cohort: Prospective

Sampling procedure

Probability: Stratified

Biobank is connected to the study

Yes

Subject area

HEALTH (CESSDA Topic Classification)
Endocrinology and Diabetes (The Swedish standard of fields of research 2011)

Keywords

longitudinal studies, glucose tolerance test, women, atherosclerosis, glucose, mass screening, diabetes mellitus, type 2, metabolic status

Contact for questions about the data

Rufus Latham

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Publications

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Fagerberg B, Prahl Gullberg U, Alm R, Nilsson J, Nordin Fredrikson G. Circulating autoantibodies against the apolipoprotein B-100 peptides p45 and p210 in relation to the occurrence of carotid plaques in 64-year-old women. PLoS ONE 2015;10(3): e0120744. doi:10.1371/journal.pone.0120744
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Bergström G, Fagerberg B, Sallsten G, Lundh T, Barregard L. Is cadmium exposure associated with the burden, vulnerability and rupture of human atherosclerotic plaques? PLOS ONE (in press).

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