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DIWA - Diabetes and Impaired glucose tolerance in Women and Atherosclerosis development study

SND-ID: EXT 0140

Creator/Principal investigator(s)

Göran Bergström - University of Gothenburg, The Sahlgrenska Academy, Institute of Medicine

Description

All 64-year old women in the county of Gothenburg were invited to a screening examination including an OGTT. Glucose tolerance was defined for each participant according to the World Health Organization (WHO) criteria. Patients were divided in three sub-groups according to metabolic status and a randomized sample of patients were recruited from each group for a longitudinal follow-up study: diabetes mellitus (n = 220), impaired glucose tolerance (IGT, n = 204) or normal glucose tolerance (NGT, n = 188). Baseline examination was performed between 2002-2004 and follow-up examination in 2007-2009 (mean follow-up 5.5 years).
Datasets from papers published in open access is made available on request.

Purpose:

The aim of the DIWA-study is to investigate the development of atherosclerosis in women with different degrees of glucose control.
Research principal, contributors, and funding

Research principal

University of Gothenburg

Responsible department/unit

Institute of Medicine

Protection and ethical review
Method and time period

Unit of analysis

Population

64-year old women in Gothenburg (2002)

Time Method

Sampling procedure

Probability: Stratified

Time period(s) investigated

2002 – ongoing

Biobank is connected to the study

Yes

Geographic coverage

Geographic spread

Geographic description: Gothenburg

Topic and keywords

Research area

HEALTH (CESSDA Topic Classification)
Endocrinology and Diabetes (The Swedish standard of fields of research 2011)

Keywords

longitudinal studies, glucose tolerance test, women, atherosclerosis, glucose, mass screening, diabetes mellitus, type 2, metabolic status

Publications

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Fagerberg B, Prahl Gullberg U, Alm R, Nilsson J, Nordin Fredrikson G. Circulating autoantibodies against the apolipoprotein B-100 peptides p45 and p210 in relation to the occurrence of carotid plaques in 64-year-old women. PLoS ONE 2015;10(3): e0120744. doi:10.1371/journal.pone.0120744
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Bergström G, Fagerberg B, Sallsten G, Lundh T, Barregard L. Is cadmium exposure associated with the burden, vulnerability and rupture of human atherosclerotic plaques? PLOS ONE (in press).

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Dataset
DIWA - Diabetes and Impaired glucose tolerance in Women and Atherosclerosis development study

Data format / data structure

Numeric

Creator/Principal investigator(s)

Göran Bergström - University of Gothenburg, The Sahlgrenska Academy, Institute of Medicine

Time period(s) investigated

2002 – ongoing

Data collection 1

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2002–2004
  • Source of the data: Population group

Data collection 2

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2007–2009
  • Source of the data: Population group

Contact for questions about the data

Published: 2014-12-10
Last updated: 2020-01-17