Creator/Principal investigator(s)
Patrik Magnusson - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
Description
STR has been based at the Karolinska Institutet since 1959, first at the Institution of Hygien and thereafter at Medical Epidemiology and Biostatistics, MEB. STR was originally created primarily to study the importance of environmental factors for the development of cardiovascular/respiratory diseases and cancer, but has since then evolved to a resource for all epidemiological and genetic aspects of ill health.
The research that is based on STR is financed externally through grants that the users apply for individually. STR is in this way making up the basis for a lot of research; during the past decade over 50 articles have been published annually, where of several in high impact journals.
STR has during the past decade transformed from being primarily an epidemiological resource to forming a biobank of samples (DNA, blood and serum) for a large number of twins. Genome-wide genotyping of close to 30 000 participants have been undertaken and the plan is that all DNA samples shall become genotyped on a genome-wide platform the coming few years. Serum from 12 600 twins have so far been used
Research principal
Responsible department/unit
Department of Medical Epidemiology and Biostatistics
Unit of analysis
Population
Twin pairs, both monozygotic and dizygotic, born in Sweden
Time Method
Sampling procedure
Time period(s) investigated
1961 – ongoing
Biobank is connected to the study
Yes
Geographic spread
Geographic description: Sweden
Research area
HEALTH
(CESSDA Topic Classification)
Medical and Health Sciences, Medical Genetics, Public Health, Global Health, Social Medicine and Epidemiology
(The Swedish standard of fields of research 2011)
Keywords
behavior, arthritis, rheumatoid, child, diabetes mellitus, family, genetics, cardiovascular diseases, health, hypertension, food habits, migraine disorders, environment, environmental exposure, parkinson disease, smoking, disease, tobacco, fatigue, heredity, twin study, youth, cohorts.se, swedish cohort consortium (scc), heritability
Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E, Björk C, Svartengren M, Wolk A, Klareskog L, de Faire U, Schalling M, Palmgren J, Pedersen NL. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet. 2006 Dec;9(6):875-82. PubMed PMID: 17254424.
Magnusson PK, Almqvist C, Rahman I, Ganna A, Viktorin A, Walum H, Halldner L, Lundström S, Ullén F, Långström N, Larsson H, Nyman A, Gumpert CH, Råstam M, Anckarsäter H, Cnattingius S, Johannesson M, Ingelsson E, Klareskog L, de Faire U, Pedersen NL, Lichtenstein P. The Swedish Twin Registry: establishment of a biobank and other recent developments. Twin Res Hum Genet. 2013 Feb;16(1):317-29. doi: 10.1017/thg.2012.104. Epub 2012 Nov 9. PubMed PMID: 23137839.
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Data format / data structure
Numeric
Other
Creator/Principal investigator(s)
Patrik Magnusson - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics