Swedish Twin Registry

SND-ID: EXT 0163

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Description Data and documentation

Creator/Principal investigator(s)

Patrik Magnusson - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics

Description

STR has been based at the Karolinska Institutet since 1959, first at the Institution of Hygien and thereafter at Medical Epidemiology and Biostatistics, MEB. STR was originally created primarily to study the importance of environmental factors for the development of cardiovascular/respiratory diseases and cancer, but has since then evolved to a resource for all epidemiological and genetic aspects of ill health.
The research that is based on STR is financed externally through grants that the users apply for individually. STR is in this way making up the basis for a lot of research; during the past decade over 50 articles have been published annually, where of several in high impact journals.
STR has during the past decade transformed from being primarily an epidemiological resource to forming a biobank of samples (DNA, blood and serum) for a large number of twins. Genome-wide genotyping of close to 30 000 participants have been undertaken and the plan is that all DNA samples shall become genotyped on a genome-wide platform the coming few years. Serum from 12 600 twins have so far been used

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Research principal, contributors, and funding
Protection and ethical review
Method

Unit of analysis

Population

Twin pairs, both monozygotic and dizygotic, born in Sweden

Time Method

Sampling procedure

Total universe/Complete enumeration

Time period(s) investigated

1961–ongoing

Biobank is connected to the study

Yes

Geographic coverage

Geographic spread

Geographic description: Sweden

Publications

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Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E, Björk C, Svartengren M, Wolk A, Klareskog L, de Faire U, Schalling M, Palmgren J, Pedersen NL. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet. 2006 Dec;9(6):875-82. PubMed PMID: 17254424.

Magnusson PK, Almqvist C, Rahman I, Ganna A, Viktorin A, Walum H, Halldner L, Lundström S, Ullén F, Långström N, Larsson H, Nyman A, Gumpert CH, Råstam M, Anckarsäter H, Cnattingius S, Johannesson M, Ingelsson E, Klareskog L, de Faire U, Pedersen NL, Lichtenstein P. The Swedish Twin Registry: establishment of a biobank and other recent developments. Twin Res Hum Genet. 2013 Feb;16(1):317-29. doi: 10.1017/thg.2012.104. Epub 2012 Nov 9. PubMed PMID: 23137839.

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Access to data via

Dataset
Swedish Twin Registry

Data format / data structure

Numeric

Other

Creator/Principal investigator(s)

Patrik Magnusson - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics

Data collection 1

  • Time period(s) for data collection: 1961–ongoing
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 2

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1961–ongoing
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Data collection 3

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1961–ongoing
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples

Contact for questions about the data

Published: 2015-06-11
Last updated: 2017-02-27