Swedish Twin Registry
SND-ID: ext0163-1.
Is part of collection at SND: Swedish Cohort Consortium (Cohorts.se)
Creator/Principal investigator(s)
Patrik Magnusson - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
Research principal
Karolinska Institutet
- Department of Medical Epidemiology and Biostatistics
Description
STR has been based at the Karolinska Institutet since 1959, first at the Institution of Hygien and thereafter at Medical Epidemiology and Biostatistics, MEB. STR was originally created primarily to study the importance of environmental factors for the development of cardiovascular/respiratory diseases and cancer, but has since then evolved to a resource for all epidemiological and genetic aspects of ill health.
The research that is based on STR is financed externally through grants that the users apply for individually. STR is in this way making up the basis for a lot of research; during the past decade over 50 articles have been published annually, where of several in high impact journals.
STR has during the past decade transformed from being primarily an epidemiological resource to forming a biobank of samples (DNA, blood and serum) for a large number of twins. Genome-wide genotyping of close to 30 000 participants have been undertaken and the plan is that all DNA samples shall become genotyped on a genome-wide platform the coming few years. Serum from 12 600 twins have so far been used
The research that is based on STR is financed externally through grants that the users apply for individually. STR is in this way making up the basis for a lot of research; during the past decade over 50 articles have been published annually, where of several in high impact journals.
STR has during the past decade transformed from being primarily an epidemiological resource to forming a biobank of samples (DNA, blood and serum) for a large number of twins. Genome-wide genotyping of close to 30 000 participants have been undertaken and the plan is that all DNA samples shall become genotyped on a genome-wide platform the coming few years. Serum from 12 600 twins have so far been used for measurements of classical blood biomarkers. Generated genotypes and biomarker measurements builds in an effective manner up the value of STR as an molecular epidemiological resource.
Purpose:
The goal of the Swedish Twin Registry (STR) is to provide a longitudinal research infrastructure in the form of a population-based twin cohort of adequate size and content to enable powerful epidemiological and molecular medical studies. The study designs used are classical epidemiological investigations of risk-factors for disease and death (providing within twin pair designs), genetic association studies, heritability studies (both twin model based and molecular based), epigenetics, proteomics as well as other types of "-omics" approaches. STR is open for Swedish researchers and international researchers that have a Swedish collaborator. Show less..
Unit of analysis
Population
Twin pairs, both monozygotic and dizygotic, born in Sweden
Time Method
Sampling procedure
Time period(s) investigated
1961 – Ongoing
Biobank is connected to the study
Yes
Geographic spread
Geographic description: Sweden
Responsible department/unit
Department of Medical Epidemiology and Biostatistics
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Medical genetics (Standard för svensk indelning av forskningsämnen 2011)
Public health, global health, social medicine and epidemiology (Standard för svensk indelning av forskningsämnen 2011)
Health (CESSDA Topic Classification)
Keywords
Behavior, Arthritis, rheumatoid, Child, Diabetes mellitus, Family, Genetics, Cardiovascular diseases, Health, Hypertension, Migraine disorders, Environment, Environmental exposure, Parkinson disease, Smoking, Disease, Tobacco, Fatigue, Heredity, Twin study, Youth, Feeding behavior, Swedish cohort consortium (scc), Heritability, Cohorts.se
Magnusson PK, Almqvist C, Rahman I, Ganna A, Viktorin A, Walum H, Halldner L,
Lundström S, Ullén F, Långström N, Larsson H, Nyman A, Gumpert CH, Råstam M,
Anckarsäter H, Cnattingius S, Johannesson M, Ingelsson E, Klareskog L, de Faire
U, Pedersen NL, Lichtenstein P. The Swedish Twin Registry: establishment of a
biobank and other recent developments. Twin Res Hum Genet. 2013 Feb;16(1):317-29.
doi: 10.1017/thg.2012.104. Epub 2012 Nov 9. PubMed PMID: 23137839.
Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E,
Björk C, Svartengren M, Wolk A, Klareskog L, de Faire U, Schalling M, Palmgren J,
Pedersen NL. The Swedish Twin Registry in the third millennium: an update. Twin
Res Hum Genet. 2006 Dec;9(6):875-82. PubMed PMID: 17254424.
If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.