Respiratory Health In Northern Europe

SND-ID: EXT 0164

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Description Data and documentation

Creator/Principal investigator(s)

Christer Janson - Uppsala University, Department of Medical Sciences

Description

The Respiratory Health in Northern Europe (RHINE) is a follow-up study of participants from seven Northern European centres who participated in European Community Respiratory Health Survey (ECRHS) stage I. The target population for the RHINE study were all subjects (n=21,802) from Reykjavik in Iceland, Bergen in Norway, Umeå, Uppsala and Göteborg in Sweden, Aarhus in Denmark and Tartu in Estonia that participated in stage 1 of the ECRHS (response rate 83.7%). The eligible subjects were sent a postal questionnaire in 1999-2001. In total 16,191 (74.3%) subjects answered the questionnaire.This questionnaire includes questions on respiratory symptoms, asthma, rhinitis, bronchitis, smoking, indoor environment, occupation, early life exposure and sleep disorders.

Part of this population are part of the ECRHS II
The ECRHS II is a follow-up survey of subjects from 14 countries who participated in the clinical phase of ECRHS I (3,4). The study is funded by the European Commission, as well as other sources of funding, as part of their Quality of Life Programme.The participants answered a detailed structured interview about symptoms, exposure to known or suspected risk factors for asthma, occupation and health service utilisation. Blood was taken for measurement of specific IgE to house dust mite, grass, cat and Cladosporium and DNA extraction (not all centres). Spirometry and methacholine challenge was performed. Health related quality of life was assessed by self completed questionnaires: SF-36 and AQLQ. In a sub-sample home visits were made to measure exposure to house dust mites and cat allergens. Throughout the study outdoor exposure to PM2.5, PM10 and NO2 was measured in the centres participating in the study.

A follow up of the RHINE and ECRHS populations was conducted in 2010-2012: RHINE III and ECRHS III

Purpose:

1. To assess the incidence and remission rate of asthma and allergic rhinitis and to determine risk factors in a representative Nordic population sample.

2. To assess the influence of occupational and home related environmental exposure on the development of asthma and allergic rhinitis in Northern Europe.

3. To investigate the association between the menstrual cycle and asthmatic symptoms in women.

4. To assess the incidence and remission of sleep disturbances and determine risk factors including atopy and asthma. Show less..

Research principal, contributors, and funding

Research principal

Uppsala University

Responsible department/unit

Uppsala University, Department of Medical Sciences

Protection and ethical review

Method

Unit of analysis

Individual

Time Method

Longitudinal: Cohort: Prospective

Sampling procedure

Probability: Simple random

Geographic coverage

Topic and keywords

Subject area

HEALTH (CESSDA Topic Classification)
Medical and Health Sciences, Public Health, Global Health, Social Medicine and Epidemiology (The Swedish standard of fields of research 2011)

Keywords

risk factors, women, asthma, environmental exposure, sleep wake disorders, menstrual cycle, rhinitis, allergic, cohorts.se, swedish cohort consortium (scc)

Publications

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Gunnbjörnsdóttir MI, Franklin KA, Norbäck D, Björnsson E, Gislason D, Lindberg E, Svanes C, Omenaas E, Norrman E, Jõgi R, Juel Jensen E, Dahlman-Höglund A, Janson C; RHINE Study Group. Prevalence and incidence of respiratory symptoms in relationship to indoor dampness: the RHINE study. Thorax 2006; 61:221-225.
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Modig L, Torén K, Janson C, Järvholm B, Forsberg B. Vehicle exhausts outside the home and onset of asthma among adults. A prospective cohort study. Eur Respir J 2009; 33: 1258-1264
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Access to data via

Homepage

The study homepage

Contact

Christer Janson

Information about using data

Dataset

Respiratory Health In Northern Europe

Data format / data structure

Numeric

Creator/Principal investigator(s)

Christer Janson - Uppsala University, Department of Medical Sciences