Creator/Principal investigator(s)
Liisa Byberg - Uppsala University, Department of Surgical Sciences
Description
The Uppsala Family Study was initiated in 2000-2001 when 602 families (mothers, fathers, two consecutive siblings age 5-14 years) living in Uppsala were examined with focus on anthropometry and blood pressure. Blood samples were taken for biochemical and genetic analyses. Parents answered medical and lifestyle questionnaires and filled in a medical questionnaire for each child. Families were randomly selected from a sampling frame where children were selected from the Medical Birth Registry based on them being consecutive singleton full siblings where both had high or low birth weight or where they were discordant in birth weight. In 2010-2014, all families were invited for a second round of examinations; 513 parents (age 39-70 years) and 466 children (age 14-23 years) attended. This second round of examinations included largely the same procedures as the first round; anthropometry, blood pressure, blood sampling, and all participants answered a detailed questionnaire on medical history, lifestyle habits including physical activity, education and living conditions. Additionally, participants u
... Show more..Research principal
Responsible department/unit
Department of Surgical Sciences
Unit of analysis
Time Method
Sampling procedure
Research area
HEALTH
(CESSDA Topic Classification)
Medical and Health Sciences
(The Swedish standard of fields of research 2011)
Silverwook RJ, De Stavola BL, Cole TJ, Leon DA. BMI peak in infancy as a predictor for later BMI in the Uppsala Family Study. Int J Obes 2009;33(8):929-37. doi: 10.1038/ijo.2009.108
Khanolkar AR, Byberg L, Koupil I. Parental influences on cardiovascular risk factors in Swedish children aged 5-14 years. Eur J Public Health 2012;22(6):840-7. doi: 10.1093/eurpub/ckr180
Leon DA, Koupil I, Mann V, Tuvemo T, Lindmark G, Mohsen R, Byberg L, Lithell H. Fetal, developmental, and parental influences on childhood systolic blood pressure in 600 sib pairs: the Uppsala Family Study. Circulation 2005;112(22):3478-85. doi: 10.1161/CIRCULATIONAHA.104.497610
Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V, Axelsson T, Syvänen AC, Leon D, Hattersley AT. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 2005;54(2):576-81. doi: 10.2337/diabetes.54.2.576
Nitsch D, Sandling JK, Byberg L, Larsson A, Tuvemo T, Syvänen AC, Koupil I, Leon DA. Fetal, developmental and parental influences on cystatin C in childhood: the Uppsala Family Study. Am J Kidney Dis 2011;57(6):863-72. doi: 10.1053/j.ajkd.2010.12.025
Mann V, De Stavola BL, Leon DA. Separating within and between effects in family studies: an application to the study of blood pressure in children. Stat Med 2004; 23(17):2745-56.
Koupil I. The Uppsala studies on developmental origins of health and disease. J Intern Med 2007;261(5):426-36.
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Contact
Liisa Byberg
Data format / data structure
Numeric
Creator/Principal investigator(s)
Liisa Byberg - Uppsala University, Department of Surgical Sciences