Uppsala Family Study

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s):

Liisa Byberg - Uppsala University, Department of Surgical Sciences

Description:

The Uppsala Family Study was initiated in 2000-2001 when 602 families (mothers, fathers, two consecutive siblings age 5-14 years) living in Uppsala were examined with focus on anthropometry and blood pressure. Blood samples were taken for biochemical and genetic analyses. Parents answered medical and lifestyle questionnaires and filled in a medical questionnaire for each child. Families were randomly selected from a sampling frame where children were selected from the Medical Birth Registry based on them being consecutive singleton full siblings where both had high or low birth weight or where they were discordant in birth weight. In 2010-2014, all families were invited for a second round of examinations; 513 parents (age 39-70 years) and 466 children (age 14-23 years) attended. This second round of examinations included largely the same procedures as the first round; anthropometry, blood pressure, blood sampling, and all participants answered a detailed questionnaire on medical history, lifestyle habits including physical activity, education and living conditions. Additionally, participants u

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Subject area:

HEALTH (CESSDA Topic Classification)

Creator/Principal investigator(s):

Liisa Byberg - Uppsala University, Department of Surgical Sciences

Identifiers:

SND-ID: EXT 0175

Purpose:

To study effects of birth weight and growth on cardiovascular, metabolic and bone-related outcomes using a family design.

Description:

The Uppsala Family Study was initiated in 2000-2001 when 602 families (mothers, fathers, two consecutive siblings age 5-14 years) living in Uppsala were examined with focus on anthropometry and blood pressure. Blood samples were taken for biochemical and genetic analyses. Parents answered medical and lifestyle questionnaires and filled in a medical questionnaire for each child. Families were randomly selected from a sampling frame where children were selected from the Medical Birth Registry based on them being consecutive singleton full siblings where both had high or low birth weight or where they were discordant in birth weight. In 2010-2014, all families were invited for a second round of examinations; 513 parents (age 39-70 years) and 466 children (age 14-23 years) attended. This second round of examinations included largely the same procedures as the first round; anthropometry, blood pressure, blood sampling, and all participants answered a detailed questionnaire on medical history, lifestyle habits including physical activity, education and living conditions. Additionally, participants u

... Show more..

Unit of analysis:

Sampling procedure:

Probability

Subject area:

HEALTH (CESSDA Topic Classification)

Contact person for questions about the data:

Liisa Byberg

Publications

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Leon DA, Koupil I, Mann V, Tuvemo T, Lindmark G, Mohsen R, Byberg L, Lithell H. Fetal, developmental, and parental influences on childhood systolic blood pressure in 600 sib pairs: the Uppsala Family Study. Circulation 2005;112(22):3478-85. doi: 10.1161/CIRCULATIONAHA.104.497610

Khanolkar AR, Byberg L, Koupil I. Parental influences on cardiovascular risk factors in Swedish children aged 5-14 years. Eur J Public Health 2012;22(6):840-7. doi: 10.1093/eurpub/ckr180

Nitsch D, Sandling JK, Byberg L, Larsson A, Tuvemo T, Syvänen AC, Koupil I, Leon DA. Fetal, developmental and parental influences on cystatin C in childhood: the Uppsala Family Study. Am J Kidney Dis 2011;57(6):863-72. doi: 10.1053/j.ajkd.2010.12.025

Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V, Axelsson T, Syvänen AC, Leon D, Hattersley AT. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 2005;54(2):576-81. doi: 10.2337/diabetes.54.2.576

Silverwook RJ, De Stavola BL, Cole TJ, Leon DA. BMI peak in infancy as a predictor for later BMI in the Uppsala Family Study. Int J Obes 2009;33(8):929-37. doi: 10.1038/ijo.2009.108

Mann V, De Stavola BL, Leon DA. Separating within and between effects in family studies: an application to the study of blood pressure in children. Stat Med 2004; 23(17):2745-56.

Koupil I. The Uppsala studies on developmental origins of health and disease. J Intern Med 2007;261(5):426-36.

If you have published anything based on these data, please notify us with a reference to your publication(s).

Uppsala Family Study

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 2000 — 2001

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2000 — 2001

Source of the data: Population group, Biological samples

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 2010 — 2014

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 2010 — 2014

Source of the data: Population group, Biological samples