Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA)

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description:

In OPRA, a total of 1,044 women (response rate 65%) underwent baseline investigation (1995-1999). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 75 years at inclusion, community dwelling and Swedish citizens resident in Malmö; no exclusion criteria were applied. Additional investigations were performed after 5- and 10-years.

The investigations included bone mineral density (BMD) and body composition measurements, anthropometrics and BioDex isokinetic muscle force. Questionnaires provide information on lifestyle, health, food/nutrition and hormonal function. Validated instruments for outcome (SF-36, EQ5D and Qualeffo-radius), ADL-function and mental status are also available. Information on adult fractures sustained prior to inclusion was collected and information on incident fractures was continuously registered until October 2012 (~15 years) through the X-rays files at the Radiology Department, Malmö, Skåne University Hospital. Blood and urine samples were collected.

Extensive phenotyping includes: bone turnover markers, FRAX probability scores, a qu

... Show more..

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Identifiers:

SND-ID: EXT 0266

Purpose:

The OPRA cohort was designed to enable identification of gene variants and other associated risk factors related to bone loss and fracture in elderly women already at an age when fracture incidence begins to increase.

Description:

In OPRA, a total of 1,044 women (response rate 65%) underwent baseline investigation (1995-1999). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 75 years at inclusion, community dwelling and Swedish citizens resident in Malmö; no exclusion criteria were applied. Additional investigations were performed after 5- and 10-years.

The investigations included bone mineral density (BMD) and body composition measurements, anthropometrics and BioDex isokinetic muscle force. Questionnaires provide information on lifestyle, health, food/nutrition and hormonal function. Validated instruments for outcome (SF-36, EQ5D and Qualeffo-radius), ADL-function and mental status are also available. Information on adult fractures sustained prior to inclusion was collected and information on incident fractures was continuously registered until October 2012 (~15 years) through the X-rays files at the Radiology Department, Malmö, Skåne University Hospital. Blood and urine samples were collected.

Extensive phenotyping includes: bone turnover markers, FRAX probability scores, a qu

... Show more..

Time period(s) investigated:

1995 — ongoing

Data collection:

Mode of collection: Measurements and tests

Time period(s) for data collection: 1995

Source of the data: Population group, Biological samples

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1995

Source of the data: Population group, Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1995

Source of the data: Population group, Biological samples

Unit of analysis:

Sampling procedure:

Probability
During the recruitment period (1995–‘99) n=1604 randomly selected women were invited by letter one week after their 75th birthday, to attend investigation. This sample represents 33% of all women of this age living in Malmö during the study.

Data contains personal data:

Yes

Ethics Review:

Lund —2014/804

Biobank is connected to the study:

Yes

Funding:

Swedish Research Council —K2015-52X-14691-13-4

Contact person for questions about the data:

Fiona McGuigan

Publications

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Ringsberg K, Gerdhem P, Johansson J, Obrant KJ. Is there a relationship between balance, gait performance and muscular strength in 75-year-old women?. Age Ageing. 1999 May;28(3):289-93.

If you have published anything based on these data, please notify us with a reference to your publication(s).

Dataset EXT 0266-001

Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) - baseline

Data format / data structure:

Numeric

Time period(s) investigated:

1995 — 1999

Number of individuals/objects:

1044

Response rate/participation rate:

65 %

Dataset EXT 0266-002

Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) - 5-year follow-up

Data format / data structure:

Numeric

Dataset EXT 0266-003

Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA): 10-year follow-up

Data format / data structure:

Numeric