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Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA)

SND-ID: EXT 0266

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description

In OPRA, a total of 1,044 women (response rate 65%) underwent baseline investigation (1995-1999). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 75 years at inclusion, community dwelling and Swedish citizens resident in Malmö; no exclusion criteria were applied. Additional investigations were performed after 5- and 10-years.

The investigations included bone mineral density (BMD) and body composition measurements, anthropometrics and BioDex isokinetic muscle force. Questionnaires provide information on lifestyle, health, food/nutrition and hormonal function. Validated instruments for outcome (SF-36, EQ5D and Qualeffo-radius), ADL-function and mental status are also available. Information on adult fractures sustained prior to inclusion was collected and information on incident fractures was continuously registered until October 2012 (~15 years) through the X-rays files at the Radiology Department, Malmö, Skåne University Hospital. Blood and urine samples were collected.

Extensive phenotyping includes: bone turnover markers, FRAX probability scores, a qu

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Research principal, contributors, and funding

Research principal

Lund University

Responsible department/unit

Department of Clinical Sciences

Funding

  • Funding agency: Swedish Research Council
  • Funding agency's reference number: K2015-52X-14691-13-4
Protection and ethical review

Ethics Review

Lund - Ref. 2014/804

Method and time period

Unit of analysis

Time Method

Sampling procedure

Probability
During the recruitment period (1995–‘99) n=1604 randomly selected women were invited by letter one week after their 75th birthday, to attend investigation. This sample represents 33% of all women of this age living in Malmö during the study.

Time period(s) investigated

1995 – ongoing

Biobank is connected to the study

Yes

Geographic coverage
Topic and keywords

Research area

HEALTH (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

Keywords

activities of daily living, blood specimen collection, body composition, skeleton, longitudinal studies, urine specimen collection, women, phenotype, bone density, anthropology, cohorts.se

Publications

Sort by name | Sort by year

Ringsberg K, Gerdhem P, Johansson J, Obrant KJ. Is there a relationship between balance, gait performance and muscular strength in 75-year-old women?. Age Ageing. 1999 May;28(3):289-93.

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

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Contact

Dataset 1
Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) - baseline

Associated documentation

Data format / data structure

Numeric

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Time period(s) investigated

1995 – 1999

Data collection 1

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Population group, Biological samples

Data collection 2

  • Mode of collection: Observation
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Population group

Data collection 3

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Biological samples

Number of individuals/objects

1044

Response rate/participation rate

65%

Dataset 2
Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) - 5-year follow-up

Associated documentation

Data format / data structure

Numeric

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data collection 1

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Population group, Biological samples

Data collection 2

  • Mode of collection: Observation
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Population group

Data collection 3

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Biological samples
Dataset 3
Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA): 10-year follow-up

Associated documentation

Data format / data structure

Numeric

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data collection 1

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Population group, Biological samples

Data collection 2

  • Mode of collection: Observation
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Population group

Data collection 3

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 1995–ongoing
  • Source of the data: Biological samples

Contact for questions about the data

Related research data in SND's catalogue

Is part of collection at SND

Swedish Cohort Consortium (Cohorts.se)

Published: 2017-03-01
Last updated: 2020-01-27