Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA)

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description:

In OPRA, a total of 1,044 women (response rate 65%) underwent baseline investigation (1995-1999). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 75 years at inclusion, community dwelling and Swedish citizens resident in Malmö; no exclusion criteria were applied. Additional investigations were performed after 5- and 10-years.

The investigations included bone mineral density (BMD) and body composition measurements, anthropometrics and BioDex isokinetic muscle force. Questionnaires provide information on lifestyle, health, food/nutrition and hormonal function. Validated instruments for outcome (SF-36, EQ5D and Qualeffo-radius), ADL-function and mental status are also available. Information on adult fractures sustained prior to inclusion was collected and information on incident fractures was continuously registered until October 2012 (~15 years) through the X-rays files at the Radiology Department, Malmö, Skåne University Hospital. Blood and urine samples were collected.

Extensive phenotyping includes: bone turnover markers, FRAX probability scores, a qu

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Subject area:

Responsible department/unit:

Lund University, Department of Clinical Sciences

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Identifiers:

SND-ID: EXT 0266

Description:

In OPRA, a total of 1,044 women (response rate 65%) underwent baseline investigation (1995-1999). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 75 years at inclusion, community dwelling and Swedish citizens resident in Malmö; no exclusion criteria were applied. Additional investigations were performed after 5- and 10-years.

The investigations included bone mineral density (BMD) and body composition measurements, anthropometrics and BioDex isokinetic muscle force. Questionnaires provide information on lifestyle, health, food/nutrition and hormonal function. Validated instruments for outcome (SF-36, EQ5D and Qualeffo-radius), ADL-function and mental status are also available. Information on adult fractures sustained prior to inclusion was collected and information on incident fractures was continuously registered until October 2012 (~15 years) through the X-rays files at the Radiology Department, Malmö, Skåne University Hospital. Blood and urine samples were collected.

Extensive phenotyping includes: bone turnover markers, FRAX probability scores, a qu

... Show more..

Time period(s) investigated:

1995 — ongoing

Unit of analysis:

Sampling procedure:

Probability

Ethics Review:

Lund — Ref. 2014/804

Biobank is connected to the study:

Yes

Funding:

Swedish Research Council — Ref. K2015-52X-14691-13-4

Subject area:

Contact for questions about the data:

Fiona McGuigan

Available documentation:

Download metadata:

Publications

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Ringsberg K, Gerdhem P, Johansson J, Obrant KJ. Is there a relationship between balance, gait performance and muscular strength in 75-year-old women?. Age Ageing. 1999 May;28(3):289-93.

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Dataset 1

Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) - baseline

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1995

Source of the data: Population group, Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1995

Source of the data: Population group

Mode of collection: Measurements and tests

Time period(s) for data collection: 1995

Source of the data: Biological samples

Time period(s) investigated:

1995 — 1999

Number of individuals/objects:

1044

Response rate/participation rate:

65 %

Dataset 2

Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) - 5-year follow-up

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1995

Source of the data: Population group, Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1995

Source of the data: Population group

Mode of collection: Measurements and tests

Time period(s) for data collection: 1995

Source of the data: Biological samples

Dataset 3

Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA): 10-year follow-up

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1995

Source of the data: Population group, Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1995

Source of the data: Population group

Mode of collection: Measurements and tests

Time period(s) for data collection: 1995

Source of the data: Biological samples

Published: 2017-03-01
Last updated: 2020-01-27