The PEAK-25 cohort

This study is part of the collection Swedish Cohort Consortium (Cohorts.se) , Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description:

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

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Subject area:

Responsible department/unit:

Lund University, Department of Clinical Sciences

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Contributor(s):

Region Skåne

Identifiers:

SND-ID: EXT 0267

Description:

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

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Time period(s) investigated:

1999 — ongoing

Geographic spread:

Geographic location: Sweden, Skåne County

Unit of analysis:

Sampling procedure:

Probability

Ethics Review:

Lund — Ref. 567/2008

Biobank is connected to the study:

Yes

Funding:

Swedish Research Council — Ref. K2015-52X-14691-13-4

Subject area:

Contact for questions about the data:

Fiona McGuigan

Is part of collection at SND:

Swedish Cohort Consortium (Cohorts.se)

Scania Metadatabase for Epidemiology (SME)

Available documentation:

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Dataset 1

The PEAK-25 cohort: baseline

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure:

Numeric

Data collection:

Mode of collection: Measurements and tests

Time period(s) for data collection: 1999 — 2004

Source of the data: Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1999 — 2004

Source of the data: Population group

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1999 — 2004

Source of the data: Population group

Time period(s) investigated:

1999 — ongoing

Number of individuals/objects:

1061

Response rate/participation rate:

49 %

Dataset 2

The PEAK-25 cohort: 10-year follow-up

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure:

Numeric

Published: 2017-03-02
Last updated: 2020-04-28