The PEAK-25 cohort

SND-ID: EXT 0267

This study is part of the collection Swedish Cohort Consortium (Cohorts.se) , Scania Metadatabase for Epidemiology (SME)

Description Data and documentation

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

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Research principal, contributors, and funding

Research principal

Lund University

Contributor(s)

Region Skåne

Funding

  • Funding agency: Swedish Research Council
  • Funding agency's reference number: K2015-52X-14691-13-4
Protection and ethical review

Ethics Review

Lund - Ref. 567/2008

Method and time period

Unit of analysis

Sampling procedure

Probability
The subjects were randomly selected through the computerized administrative population system. All women were Swedish citizens and resident in Malmö. A total of 2,394 invitations were sent shortly after their 25th birthday and 1,166 agreed to participate (response rate, 49%). After exclusion of 102 women who were pregnant or had been pregnant during the previous 12 months) and 3 who were out with the age criteria (range 25.01–25.99) the final cohort consists of n=1061 young adult women. This sample represents xx% of all women of this age living in Malmö during the study.

Time period(s) investigated

1999–ongoing

Biobank is connected to the study

Yes

Geographic coverage

Geographic spread

Geographic location: Sweden, Skåne County

Publications

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Access to data via

Dataset 1
The PEAK-25 cohort: baseline

Associated documentation

Data format / data structure

Numeric

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Time period(s) investigated

1999–ongoing

Data collection 1

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 1999–2004
  • Source of the data: Biological samples

Data collection 2

  • Mode of collection: Observation
  • Time period(s) for data collection: 1999–2004
  • Source of the data: Population group

Data collection 3

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1999–2004
  • Source of the data: Population group

Number of individuals/objects

1061

Response rate/participation rate

49

Dataset 2
The PEAK-25 cohort: 10-year follow-up

Associated documentation

Data format / data structure

Numeric

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Contact for questions about the data

Is part of collection at SND

Swedish Cohort Consortium (Cohorts.se)

Scania Metadatabase for Epidemiology (SME)

Published: 2017-03-02
Last updated: 2020-04-28