The PEAK-25 cohort

This study is part of the collection Swedish Cohort Consortium (Cohorts.se) , Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description:

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

... Show more..

Creator/Principal investigator(s):

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Identifiers:

SND-ID: EXT 0267

Purpose:

This cohort was designed to include women at an age closely representing ‘pure’ peak bone mass, prior to any major perturbations from external or internal factors causing loss of bone. Essentially it is a period of intact coupling between bone formation and resorption. The aim of the study was identification of gene variants and other associated risk factors for osteoporosis on the attainment of peak bone mass.

Description:

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

... Show more..

Time period(s) investigated:

1999 — ongoing

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1999

Source of the data: Population group, Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1999

Source of the data: Population group, Biological samples

Mode of collection: Measurements and tests

Time period(s) for data collection: 1999

Source of the data: Population group, Biological samples

Geographic spread:

Geographic location: Sweden, Skåne County

Unit of analysis:

Sampling procedure:

Probability
The subjects were randomly selected through the computerized administrative population system. All women were Swedish citizens and resident in Malmö. A total of 2,394 invitations were sent shortly after their 25th birthday and 1,166 agreed to participate (response rate, 49%). After exclusion of 102 women who were pregnant or had been pregnant during the previous 12 months) and 3 who were out with the age criteria (range 25.01–25.99) the final cohort consists of n=1061 young adult women. This sample represents xx% of all women of this age living in Malmö during the study.

Data contains personal data:

Yes

Ethics Review:

Lund —567/2008

Biobank is connected to the study:

Yes

Funding:

Swedish Research Council —K2015-52X-14691-13-4

Contact person for questions about the data:

Fiona McGuigan

Is part of collection at SND:

Swedish Cohort Consortium (Cohorts.se)

Scania Metadatabase for Epidemiology (SME)

Dataset EXT 0267-001

The PEAK-25 cohort: baseline

Data format / data structure:

Numeric

Time period(s) investigated:

1999 — ongoing

Number of individuals/objects:

1061

Response rate/participation rate:

49 %

Dataset EXT 0267-002

The PEAK-25 cohort: 10-year follow-up

Data format / data structure:

Numeric