The PEAK-25 cohort

This study is part of the collection Swedish Cohort Consortium (Cohorts.se) , Scania Metadatabase for Epidemiology (SME)

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Description

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

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Subject area

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Contributor(s)

Region Skåne

Identifiers

SND-ID: EXT 0267

Description

The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally.
By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women.

In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 mo

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Time period(s) investigated

1999 — ongoing

Geographic spread

Geographic location: Sweden, Skåne County

Unit of analysis

Sampling procedure

Probability
The subjects were randomly selected through the computerized administrative population system. All women were Swedish citizens and resident in Malmö. A total of 2,394 invitations were sent shortly after their 25th birthday and 1,166 agreed to participate (response rate, 49%). After exclusion of 102 women who were pregnant or had been pregnant during the previous 12 months) and 3 who were out with the age criteria (range 25.01–25.99) the final cohort consists of n=1061 young adult women. This sample represents xx% of all women of this age living in Malmö during the study.

Ethics Review

Lund — Ref. 567/2008

Biobank is connected to the study

Yes

Funding

Funding agency: Swedish Research Council

Funding agency’s reference number: K2015-52X-14691-13-4

Subject area

Contact for questions about the data

Is part of collection at SND

Swedish Cohort Consortium (Cohorts.se)

Scania Metadatabase for Epidemiology (SME)

Associated documentation

Download metadata

Publications

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Dataset 1

The PEAK-25 cohort: baseline

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure

Numeric

Data collection

Mode of collection: Measurements and tests

Time period(s) for data collection: 1999 — 2004

Source of the data: Biological samples

Mode of collection: Observation

Time period(s) for data collection: 1999 — 2004

Source of the data: Population group

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1999 — 2004

Source of the data: Population group

Time period(s) investigated

1999 — ongoing

Number of individuals/objects

1061

Response rate/participation rate

49

Dataset 2

The PEAK-25 cohort: 10-year follow-up

Creator/Principal investigator(s)

Kristina Åkesson - Lund university, Department of Clinical Sciences orcid

Data format / data structure

Numeric

Published: 2017-03-02
Last updated: 2020-04-28