The primary prevention study

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s):

Annika Rosengren - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Lars Wilhelmsen - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Description:

The Primary Prevention Trial in Goteborg is a multifactorial intervention programme on coronary heart disease, stroke incidence and total mortality. The study is administered by the Section for Preventive Cardiology, Institution of Medicine, University of Gothenburg. The study started in 1970. The intervention group consisted of 10 004 men. Two control groups were of similar size. The participants were all men in Gothenburg born in 1915-1922 and 1924-1925. The first examined group was men born in 1915 and the first screening was completed 1973 with those born in 1925. A second examination started in 1974 and was completed in early spring 1977, and the final examination was performed ten years after the first one, that is between 1980 and 1983. The participants were 47-55 years of age when the study started, and accordingly 57-65 years of age at the final examination. Participation rate at the first screening examination was 75% (n=7495). The intervention group and a 2% sample of the control group 1 received an illustrated postal questionnaire dealing with family history of heart disease and s

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Creator/Principal investigator(s):

Annika Rosengren - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Lars Wilhelmsen - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Identifiers:

SND-ID: SND 0011

Purpose:

1 - to analyse the extent to which it was possible to induce changes in risk factors in a randomly selected population sample of middle-aged Swedish men by means of a population-based intervention programme which could be managed by a limited number of physicians and paramedical personnel. 2 - to measure the effect of this intervention programme on the incidence of non-fatal and fatal myocardial infarction, stroke and the total death rate in the intervention group compared with two control groups also randomly selected from the general population.

Description:

The Primary Prevention Trial in Goteborg is a multifactorial intervention programme on coronary heart disease, stroke incidence and total mortality. The study is administered by the Section for Preventive Cardiology, Institution of Medicine, University of Gothenburg. The study started in 1970. The intervention group consisted of 10 004 men. Two control groups were of similar size. The participants were all men in Gothenburg born in 1915-1922 and 1924-1925. The first examined group was men born in 1915 and the first screening was completed 1973 with those born in 1925. A second examination started in 1974 and was completed in early spring 1977, and the final examination was performed ten years after the first one, that is between 1980 and 1983. The participants were 47-55 years of age when the study started, and accordingly 57-65 years of age at the final examination. Participation rate at the first screening examination was 75% (n=7495). The intervention group and a 2% sample of the control group 1 received an illustrated postal questionnaire dealing with family history of heart disease and s

... Show more..

Language:

Swedish

Time period(s) investigated:

1970 — 1983

Geographic spread:

Geographic location: Sweden

Geographic description: The municipality of Gothenburg

Lowest geographic unit:

Municipality

Unit of analysis:

Population:

Men born 1915-1922 och 1924-1925

Sampling procedure:

Probability: Simple random

Contact person for questions about the data:

Annika Rosengren

Publications

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Jood K, Jern C, Wilhelmsen L, Rosengren A. Body mass index in mid-life is associated with a first stroke in men: a prospective population study over 28 years. Stroke 2004;35:2764-9.

Rosengren A, Skoog I, Gustafson D, Wilhelmsen L. Body mass index, other cardiovascular risk factors, and hospitalization for dementia. Arch Intern Med 2005;165:321-6.

Eriksson P, Wilhelmsen L, Rosengren A. Bundle-branch block in middle-aged men: risk of complications and death over 28 years. The Primary Prevention Study in Goteborg, Sweden. Eur Heart J 2005;26:2300-6.

Schaufelberger M, Rosengren A. Heart failure in different occupational classes in Sweden. Eur Heart J 2007;28:212-8.

Rosengren A, Fredén M, Hansson PO, Wilhelmsen L, Wedel H, Eriksson H. Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men. J Thromb Haemost 2008;6:558-64.

Adlerberth AM, Rosengren A, Wilhelmsen L. Diabetes and long-term risk of mortality from coronary and other causes in middle-aged Swedish men. A general population study. Diabetes Care. 1998 Apr;21(4):539-45.

Almgren T, Persson B, Wilhelmsen L, Rosengren A, Andersson OK. Stroke and coronary heart disease in treated hypertension - a prospective cohort study over three decades. J Intern Med. 2005 Jun;257(6):496-502.

Rosengren A, Tibblin G, Wilhelmsen L. Self-perceived psychological stress and incidence of coronary artery disease in middle-aged men. Am J Cardiol 1991;68:1171-5.

Wilhelmsen L, Berglund G, Elmfeldt D, et al. The multifactor primary prevention trial in Göteborg, Sweden. Eur Heart J 1986;7:279-88.

Molnár P, Stockfelt L, Barregard L, Sallsten G. Residential NOx exposure in a 35-year cohort study. Changes of exposure, and comparison with back extrapolation for historical exposure assessment. Atmospheric Environment 115 (2015) 62e69. doi:10.1016/j.atmosenv.2015.05.055.
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Stockfelt L, Andersson EM, Molnár P, Rosengren A, Wilhelmsen L, Sallsten G, Barregard L. Long term effects of residential NOx exposure on total and cause-specific mortality and incidence of myocardial infarction in a Swedish cohort. EnvironmentalResearch142(2015)197-206. doi:10.1016/j.envres.2015.06.045
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If you have published anything based on these data, please notify us with a reference to your publication(s).

Dataset SND 0011-001

Primary prevention study 1970-1973

Data format / data structure:

Numeric

Data collection:

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1974 — 1977

Data collector: University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Source of the data: Population group, Biological samples

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1974 — 1977

Source of the data: Population group, Biological samples

Variables:

152

Number of individuals/objects:

7495

Response rate/participation rate:

75%

Dataset SND 0011-002

Primary prevention study 1974-1977

Data format / data structure:

Numeric

Data collection:

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1970 — 1973

Source of the data: Population group, Biological samples

Time period(s) for data collection: 1977

Source of the data: Population group, Biological samples

Mode of collection: Self-administered questionnaire

Time period(s) for data collection: 1980 — 1983

Source of the data: Population group, Biological samples

Variables:

129

Number of individuals/objects:

7122

Response rate/participation rate:

75%

Dataset SND 0011-003

Primary prevention study 1980-1983

Data format / data structure:

Numeric

Data collection:

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1970 — 1973

Data collector: University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Source of the data: Population group, Biological samples

Time period(s) for data collection: 1980

Source of the data: Population group, Biological samples

Mode of collection: Physical measurements and tests

Time period(s) for data collection: 1980 — 1983

Data collector: University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Source of the data: Population group, Biological samples

Variables:

114

Number of individuals/objects:

1465

Response rate/participation rate:

75%