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The primary prevention study

SND-ID: SND 0011

This study is part of the collection Swedish Cohort Consortium (Cohorts.se)

Creator/Principal investigator(s)

Annika Rosengren - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Lars Wilhelmsen - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Description

The Primary Prevention Trial in Goteborg is a multifactorial intervention programme on coronary heart disease, stroke incidence and total mortality. The study is administered by the Section for Preventive Cardiology, Institution of Medicine, University of Gothenburg. The study started in 1970. The intervention group consisted of 10 004 men. Two control groups were of similar size. The participants were all men in Gothenburg born in 1915-1922 and 1924-1925. The first examined group was men born in 1915 and the first screening was completed 1973 with those born in 1925. A second examination started in 1974 and was completed in early spring 1977, and the final examination was performed ten years after the first one, that is between 1980 and 1983. The participants were 47-55 years of age when the study started, and accordingly 57-65 years of age at the final examination. Participation rate at the first screening examination was 75% (n=7495). The intervention group and a 2% sample of the control group 1 received an illustrated postal questionnaire dealing with family history of heart disease and s

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Language

Swedish

Research principal, contributors, and funding

Research principal

University of Gothenburg

Responsible department/unit

Department of Emergency and Cardiovascular Medicine

Protection and ethical review

Data contains personal data

No

Method and time period

Unit of analysis

Population

Men born 1915-1922 och 1924-1925

Time Method

Study design

Experimental study

Sampling procedure

Probability: Simple random

Time period(s) investigated

1970 – 1983

Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: The municipality of Gothenburg

Lowest geographic unit

Municipality

Topic and keywords

Research area

HEALTH (CESSDA Topic Classification)
Medical and Health Sciences, Clinical Medicine, Cardiac and Cardiovascular Systems (The Swedish standard of fields of research 2011)

Keywords

physical examination, body composition, electrocardiography, heart failure, longitudinal studies, exercise, population surveillance, socioeconomic factors, drug therapy, risk factors, middle aged, overweight, mortality, myocardial infarction, stroke, medical history taking, blood glucose, diabetes mellitus, epidemiology, obesity, cardiovascular diseases, health, hypertension, insulin, coffee, cholesterol, coronary disease, body height, body weight, angina pectoris, smoking, disease, morbidity, delivery of health care, stress, psychological, sleep wake disorders, triglycerides, heredity, cohorts.se, swedish cohort consortium (scc)

Publications

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Wilhelmsen L, Berglund G, Elmfeldt D, et al. The multifactor primary prevention trial in Göteborg, Sweden. Eur Heart J 1986;7:279-88.

Rosengren A, Fredén M, Hansson PO, Wilhelmsen L, Wedel H, Eriksson H. Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men. J Thromb Haemost 2008;6:558-64.

Jood K, Jern C, Wilhelmsen L, Rosengren A. Body mass index in mid-life is associated with a first stroke in men: a prospective population study over 28 years. Stroke 2004;35:2764-9.

Schaufelberger M, Rosengren A. Heart failure in different occupational classes in Sweden. Eur Heart J 2007;28:212-8.

Adlerberth AM, Rosengren A, Wilhelmsen L. Diabetes and long-term risk of mortality from coronary and other causes in middle-aged Swedish men. A general population study. Diabetes Care. 1998 Apr;21(4):539-45.

Molnár P, Stockfelt L, Barregard L, Sallsten G. Residential NOx exposure in a 35-year cohort study. Changes of exposure, and comparison with back extrapolation for historical exposure assessment. Atmospheric Environment 115 (2015) 62e69. doi:10.1016/j.atmosenv.2015.05.055.
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Rosengren A, Skoog I, Gustafson D, Wilhelmsen L. Body mass index, other cardiovascular risk factors, and hospitalization for dementia. Arch Intern Med 2005;165:321-6.

Almgren T, Persson B, Wilhelmsen L, Rosengren A, Andersson OK. Stroke and coronary heart disease in treated hypertension - a prospective cohort study over three decades. J Intern Med. 2005 Jun;257(6):496-502.

Eriksson P, Wilhelmsen L, Rosengren A. Bundle-branch block in middle-aged men: risk of complications and death over 28 years. The Primary Prevention Study in Goteborg, Sweden. Eur Heart J 2005;26:2300-6.

Rosengren A, Tibblin G, Wilhelmsen L. Self-perceived psychological stress and incidence of coronary artery disease in middle-aged men. Am J Cardiol 1991;68:1171-5.

Stockfelt L, Andersson EM, Molnár P, Rosengren A, Wilhelmsen L, Sallsten G, Barregard L. Long term effects of residential NOx exposure on total and cause-specific mortality and incidence of myocardial infarction in a Swedish cohort. EnvironmentalResearch142(2015)197-206. doi:10.1016/j.envres.2015.06.045
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Dataset 1
Primary prevention study 1970-1973

Data format / data structure

Numeric

Creator/Principal investigator(s)

Annika Rosengren - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Lars Wilhelmsen - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Data collection 1

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1974–1977
  • Data collector: University of Gothenburg, Department of Emergency and Cardiovascular Medicine
  • Source of the data: Population group, Biological samples

Data collection 2

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1974–1977
  • Source of the data: Population group, Biological samples

Variables

152

Number of individuals/objects

7495

Response rate/participation rate

75%

Dataset 2
Primary prevention study 1974-1977

Data format / data structure

Numeric

Creator/Principal investigator(s)

Annika Rosengren - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Lars Wilhelmsen - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Data collection 1

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1970–1973
  • Source of the data: Population group, Biological samples

Data collection 2

  • Time period(s) for data collection: 1977
  • Source of the data: Population group, Biological samples

Data collection 3

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 1980–1983
  • Source of the data: Population group, Biological samples

Variables

129

Number of individuals/objects

7122

Response rate/participation rate

75%

Dataset 3
Primary prevention study 1980-1983

Data format / data structure

Numeric

Creator/Principal investigator(s)

Annika Rosengren - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Lars Wilhelmsen - University of Gothenburg, Department of Emergency and Cardiovascular Medicine

Data collection 1

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1970–1973
  • Data collector: University of Gothenburg, Department of Emergency and Cardiovascular Medicine
  • Source of the data: Population group, Biological samples

Data collection 2

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 1980–1983
  • Data collector: University of Gothenburg, Department of Emergency and Cardiovascular Medicine
  • Source of the data: Population group, Biological samples

Data collection 3

  • Time period(s) for data collection: 1980
  • Source of the data: Population group, Biological samples

Variables

114

Number of individuals/objects

1465

Response rate/participation rate

75%

Contact for questions about the data

Is part of collection at SND

Swedish Cohort Consortium (Cohorts.se)

Published: 2011-01-01
Last updated: 2020-05-08