Coffee, homocysteine and B vitamins

Creator/Principal investigator(s):

Dag Thelle

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Description:

Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:



1) For 3 weeks: Both groups: no coffee



2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day



3) For 3 weeks: Both groups: no coffee (wash out)



4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.



The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits we

... Show more..

Subject area:

HEALTH, specific diseases, disorders and medical conditions (CESSDA Topic Classification)
Cardiac and Cardiovascular Systems, Nutrition and Dietetics (The Swedish standard of fields of research 2011)

Responsible department/unit:

University of Gothenburg, Department of Public Health and Community Medicine

Creator/Principal investigator(s):

Dag Thelle

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Identifiers:

SND-ID: SND 0015

Description:

Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:



1) For 3 weeks: Both groups: no coffee



2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day



3) For 3 weeks: Both groups: no coffee (wash out)



4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.



The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits we

... Show more..

Language:

Swedish

Time period(s) investigated:

2000-10 — 2001-04

Geographic spread:

Geographic location: Sweden

Unit of analysis:

Population:

The participants were in the age-range 35-69 years and usual coffee drinkers, free of clinically recognised chronic diseases such as cardiovascular diseases, cancer, renal disorders, liver disease, diabetes mellitus, and were not on anti-epileptic or chol

Sampling procedure:

Non-probability: Availability

Subject area:

HEALTH, specific diseases, disorders and medical conditions (CESSDA Topic Classification)
Cardiac and Cardiovascular Systems, Nutrition and Dietetics (The Swedish standard of fields of research 2011)

Contact for questions about the data:

Elisabeth Strandhagen

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Publications

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Strandhagen E. Coffee and gene interaction. The effect on methionine and lipid metabolism. Thesis, University of Gothenburg, 2004.
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ISBN: 91-628-6022-4

Strandhagen E, Landaas S, Thelle DS. Folate supplement eliminates the homocysteine increasing effect of filtered coffee. A randomised placebo controlled trial. Eur J Clin Nutr, 2003; 57: 1411-1417

Strandhagen E, Zetterberg H, Aires A, Palmér M, Rymo L, Blennow K, Thelle DS. The apolipoprotein E genetic polymorphism and the cholesterol raising effect of coffee. Lipids in Health and Disease 2004; 3: 26 (30Nov2004)

Strandhagen E, Thelle DS. Filtered coffee raises serum cholesterol. Results from a controlled intervention trial. Eur J Clin Nutr, 2003; 57: 1164-1168.

Strandhagen E, Zetterberg H, Aires N, Palmér M, Rymo L, Blennow K, Landaas S, Thelle DS. The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. Int J Mol Med 2004: 6: 811-5.
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Coffee, homocysteine and B vitamins

Creator/Principal investigator(s):

Dag Thelle

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Data format / data structure:

Numeric

Data collection:

Time period(s) for data collection: 2000-10 — 2001-04

Source of the data: Population group, Biological samples

Variables:

93

Number of individuals/objects:

121

Published: 2011-01-01
Last updated: 2020-05-08