Coffee, homocysteine and B vitamins

Creator/Principal investigator(s):

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Description:

Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:



1) For 3 weeks: Both groups: no coffee



2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day



3) For 3 weeks: Both groups: no coffee (wash out)



4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.



The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits we

... Show more..

Creator/Principal investigator(s):

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Identifiers:

SND-ID: SND 0015

Purpose:

To investigate the interaction of coffee consumption on the effects of folate and vitamin B-6 on the methionin metabolism and thereby on the plasma homocysteine levels.

Description:

Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:



1) For 3 weeks: Both groups: no coffee



2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day



3) For 3 weeks: Both groups: no coffee (wash out)



4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.



The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits we

... Show more..

Language:

Swedish

Time period(s) investigated:

2000-10 — 2001-04

Geographic spread:

Geographic location: Sweden

Unit of analysis:

Population:

The participants were in the age-range 35-69 years and usual coffee drinkers, free of clinically recognised chronic diseases such as cardiovascular diseases, cancer, renal disorders, liver disease, diabetes mellitus, and were not on anti-epileptic or chol

Sampling procedure:

Non-probability: Availability
The participants were recruited by advertisement in daily press.

Contact person for questions about the data:

Elisabeth Strandhagen

Publications

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Strandhagen E. Coffee and gene interaction. The effect on methionine and lipid metabolism. Thesis, University of Gothenburg, 2004.
Swepub Till lärosätets (gu) databas

Strandhagen E, Landaas S, Thelle DS. Folate supplement eliminates the homocysteine increasing effect of filtered coffee. A randomised placebo controlled trial. Eur J Clin Nutr, 2003; 57: 1411-1417

Strandhagen E, Thelle DS. Filtered coffee raises serum cholesterol. Results from a controlled intervention trial. Eur J Clin Nutr, 2003; 57: 1164-1168.

Strandhagen E, Zetterberg H, Aires N, Palmér M, Rymo L, Blennow K, Landaas S, Thelle DS. The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. Int J Mol Med 2004: 6: 811-5.
Swepub Till lärosätets (gu) databas

Strandhagen E, Zetterberg H, Aires A, Palmér M, Rymo L, Blennow K, Thelle DS. The apolipoprotein E genetic polymorphism and the cholesterol raising effect of coffee. Lipids in Health and Disease 2004; 3: 26 (30Nov2004)

If you have published anything based on these data, please notify us with a reference to your publication(s).

Available documentation:

Coffee, homocysteine and B vitamins

Data format / data structure:

Numeric

Data collection:

Time period(s) for data collection: 2000-10 — 2001-04

Source of the data: Population group, Biological samples

Variables:

93

Number of individuals/objects:

121