Creator/Principal investigator(s)
Dag Thelle
Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine
Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology
Description
Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:
1) For 3 weeks: Both groups: no coffee
2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day
3) For 3 weeks: Both groups: no coffee (wash out)
4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.
The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits we
Language
Swedish
Research principal
Responsible department/unit
Department of Public Health and Community Medicine
Data contains personal data
No
Unit of analysis
Population
The participants were in the age-range 35-69 years and usual coffee drinkers, free of clinically recognised chronic diseases such as cardiovascular diseases, cancer, renal disorders, liver disease, diabetes mellitus, and were not on anti-epileptic or chol
Study design
Experimental study
Sampling procedure
Time period(s) investigated
2000-10 – 2001-04
Geographic spread
Geographic location: Sweden
Research area
HEALTH, Specific diseases, disorders and medical conditions
(CESSDA Topic Classification)
Cardiac and Cardiovascular Systems, Nutrition and Dietetics
(The Swedish standard of fields of research 2011)
Keywords
blood pressure, blood specimen collection, homocysteine, alanine transaminase, aspartate aminotransferases, folic acid, gamma-glutamyltransferase, genes, cardiovascular diseases, [obsolete] intervention studies, coffee, cholesterol, dietary supplements, body height, body weight, nutritional sciences, placebos, smoking, triglycerides, uric acid, vitamin b complex
Strandhagen E. Coffee and gene interaction. The effect on methionine and lipid metabolism. Thesis, University of Gothenburg, 2004.
Swepub
|
Till lärosätets (gu) databas
ISBN:
91-628-6022-4
Strandhagen E, Landaas S, Thelle DS. Folate supplement eliminates the homocysteine increasing effect of filtered coffee. A randomised placebo controlled trial. Eur J Clin Nutr, 2003; 57: 1411-1417
Strandhagen E, Zetterberg H, Aires A, Palmér M, Rymo L, Blennow K, Thelle DS. The apolipoprotein E genetic polymorphism and the cholesterol raising effect of coffee. Lipids in Health and Disease 2004; 3: 26 (30Nov2004)
Strandhagen E, Thelle DS. Filtered coffee raises serum cholesterol. Results from a controlled intervention trial. Eur J Clin Nutr, 2003; 57: 1164-1168.
Strandhagen E, Zetterberg H, Aires N, Palmér M, Rymo L, Blennow K, Landaas S, Thelle DS. The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. Int J Mol Med 2004: 6: 811-5.
Swepub
|
Till lärosätets (gu) databas
If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.
Access to data via
Contact
Elisabeth Strandhagen
Associated documentation
Data format / data structure
Numeric
Creator/Principal investigator(s)
Dag Thelle
Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine
Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology
Variables
93
Number of individuals/objects
121