Coffee, homocysteine and B vitamins

SND-ID: SND 0015

Description Data and documentation

Creator/Principal investigator(s)

Dag Thelle

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Description

Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:



1) For 3 weeks: Both groups: no coffee



2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day



3) For 3 weeks: Both groups: no coffee (wash out)



4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.



The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits we

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Language

Swedish

Research principal, contributors, and funding
Protection and ethical review

Data contains personal data

No

Method

Unit of analysis

Population

The participants were in the age-range 35-69 years and usual coffee drinkers, free of clinically recognised chronic diseases such as cardiovascular diseases, cancer, renal disorders, liver disease, diabetes mellitus, and were not on anti-epileptic or chol

Sampling procedure

Non-probability: Availability
The participants were recruited by advertisement in daily press.

Time period(s) investigated

2000-10–2001-04

Geographic coverage

Geographic spread

Geographic location: Sweden

Publications

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Strandhagen E. Coffee and gene interaction. The effect on methionine and lipid metabolism. Thesis, University of Gothenburg, 2004.
Swepub Till lärosätets (gu) databas
ISBN: 91-628-6022-4

Strandhagen E, Landaas S, Thelle DS. Folate supplement eliminates the homocysteine increasing effect of filtered coffee. A randomised placebo controlled trial. Eur J Clin Nutr, 2003; 57: 1411-1417

Strandhagen E, Zetterberg H, Aires A, Palmér M, Rymo L, Blennow K, Thelle DS. The apolipoprotein E genetic polymorphism and the cholesterol raising effect of coffee. Lipids in Health and Disease 2004; 3: 26 (30Nov2004)

Strandhagen E, Thelle DS. Filtered coffee raises serum cholesterol. Results from a controlled intervention trial. Eur J Clin Nutr, 2003; 57: 1164-1168.

Strandhagen E, Zetterberg H, Aires N, Palmér M, Rymo L, Blennow K, Landaas S, Thelle DS. The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. Int J Mol Med 2004: 6: 811-5.
Swepub Till lärosätets (gu) databas

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Dataset
Coffee, homocysteine and B vitamins

Data format / data structure

Numeric

Creator/Principal investigator(s)

Dag Thelle

Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Data collection

  • Time period(s) for data collection: 2000-10–2001-04
  • Source of the data: Population group, Biological samples

Variables

93

Number of individuals/objects

121

Published: 2011-01-01
Last updated: 2020-05-08