Effect of food intake on 92 biomarkers for cardiovascular disease

SND-ID: SND 1024

Creator/Principal investigator(s)

Magnus Dencker - Skåne University Hospital, Malmö, Lund University

Description

Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD).
Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit.
Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake.

Conclusions: This study shows that food intake affects several different CVD biomarkers, but the

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Language

English

Research principal, contributors, and funding
Protection and ethical review

Ethics Review

Lund

Method and time period

Unit of analysis

Population

Healty subjects

Time Method

Sampling procedure

Total universe/Complete enumeration

Time period(s) investigated

2009-01 – 2009-09

Geographic coverage

Geographic spread

Geographic location: Sweden, Skåne County

Topic and keywords
Publications

Dencker M. Effect of food intake on 92 biomarkers for cardiovascular disease. PONE-D-17-02534R1

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Dataset
Effect of food intake on 92 biomarkers for cardiovascular disease

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Associated documentation

Description

Effect of food intake on 92 biomarkers for cardiovascular disease

Version 1.0

Citation

Magnus Dencker. Lund University, Department of Medical Imaging and Physiology (2017). Effect of food intake on 92 biomarkers for cardiovascular disease. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/002891

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Data format / data structure

Numeric

Creator/Principal investigator(s)

Magnus Dencker - Skåne University Hospital, Malmö, Lund University

Data collection

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 2009-01–2009-09
  • Source of the data: Population group, Biological samples

Variables

281

Number of individuals/objects

22

Published: 2017-05-29
Last updated: 2017-06-09