Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease

Creator/Principal investigator(s)

Magnus Dencker

Description

Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi

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Subject area

DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES) (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

Responsible department/unit

Lund University

Creator/Principal investigator(s)

Magnus Dencker

Identifiers

SND-ID: SND 1033

Description

Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi

... Show more..

Language

English

Geographic spread

Geographic location: Sweden, Skåne County

Unit of analysis

Time Method

Sampling procedure

Total universe/Complete enumeration

Ethics Review

Lund — Ref. LU 243-01

Biobank is connected to the study

Yes

Subject area

DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES) (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

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Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children

Suggested citation

Magnus Dencker. Lund University (2017). <em>Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/002921">https://doi.org/10.5878/002921</a>

Creator/Principal investigator(s)

Magnus Dencker

Description

Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 chil

... Show more..

Data format / data structure

Numeric

Variables

33

Number of individuals/objects

248

Published: 2017-10-09