Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease

Creator/Principal investigator(s):

Magnus Dencker

Description:

Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi

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Subject area:

DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES) (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

Responsible department/unit:

Lund University

Creator/Principal investigator(s):

Magnus Dencker

Identifiers:

SND-ID: SND 1033

Description:

Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi

... Show more..

Language:

English

Geographic spread:

Geographic location: Sweden, Skåne County

Unit of analysis:

Time Method:

Sampling procedure:

Total universe/Complete enumeration

Ethics Review:

Lund — Ref. LU 243-01

Biobank is connected to the study:

Yes

Subject area:

DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES) (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

Download metadata:

Version 1.0:

2017-10-09 doi:10.5878/002921

Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children

Suggested citation:

Magnus Dencker. Lund University (2017). Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/002921

Creator/Principal investigator(s):

Magnus Dencker

Description:

Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 chil

... Show more..

Data format / data structure:

Numeric

Variables:

33

Number of individuals/objects:

248

Published: 2017-10-09