Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease
Creator/Principal investigator(s):
Magnus Dencker
Description:
Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi
Subject area:
Principal organisation:
Accessibility status:
Download data:
Responsible department/unit:
Lund University
Creator/Principal investigator(s):
Magnus Dencker
Identifiers:
SND-ID: SND 1033
Description:
Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi
Language:
English
Geographic spread:
Geographic location: Sweden, Skåne County
Unit of analysis:
Time Method:
Sampling procedure:
Ethics Review:
Lund — Ref. LU 243-01
Biobank is connected to the study:
Yes
Subject area:
Download metadata:
Version 1.0:
2017-10-09
doi:10.5878/002921
Download data:
Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
Suggested citation:
Magnus Dencker. Lund University (2017). Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/002921
Creator/Principal investigator(s):
Magnus Dencker
Description:
Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 chil
Data format / data structure:
Numeric
Variables:
33
Number of individuals/objects:
248