Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease

SND-ID: SND 1033

Description Data and documentation

Creator/Principal investigator(s)

Magnus Dencker

Description

Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi

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Language

English

Research principal, contributors, and funding

Research principal

Lund University

Responsible department/unit

Lund University
Protection and ethical review

Ethics Review

Lund - Ref. LU 243-01

Method and time period

Unit of analysis

Time Method

Sampling procedure

Total universe/Complete enumeration
The study population was recruited among children at four different schools in Malmö,
Sweden. All 477 children (boys = 259, girls = 218) attending third or fourth grade were invited to participate in the study. Out of these 477 children 248 accepted the invitation (boys = 140, girls = 108), and 172 children gave blood samples (it was optional to do so). Blood samples and a complete data set of other variables were available in 170 children (92 boys and 78 girls) resulting in an inclusion frequency of
36%.

Biobank is connected to the study

Yes

Geographic coverage

Geographic spread

Geographic location: Sweden, Skåne County

Topic and keywords

Research area

DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES) (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

Publications
Dataset
Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children

Description

Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 chil

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Version 1.0

Citation

Magnus Dencker. Lund University (2017). <em>Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/002921">https://doi.org/10.5878/002921</a>

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Data format / data structure

Numeric

Creator/Principal investigator(s)

Magnus Dencker

Variables

33

Number of individuals/objects

248

Published: 2017-10-09