Creator/Principal investigator(s)
Magnus Dencker
Description
Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi
Language
English
Research principal
Responsible department/unit
Lund UniversityEthics Review
Lund - Ref. LU 243-01
Unit of analysis
Time Method
Sampling procedure
Sweden. All 477 children (boys = 259, girls = 218) attending third or fourth grade were invited to participate in the study. Out of these 477 children 248 accepted the invitation (boys = 140, girls = 108), and 172 children gave blood samples (it was optional to do so). Blood samples and a complete data set of other variables were available in 170 children (92 boys and 78 girls) resulting in an inclusion frequency of
36%.
Biobank is connected to the study
Yes
Geographic spread
Geographic location: Sweden, Skåne County
Subject area
DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES)
(CESSDA Topic Classification)
Medical and Health Sciences
(The Swedish standard of fields of research 2011)
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Description
Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 chil
Version 1.0
https://doi.org/10.5878/002921
Citation
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Data format / data structure
Numeric
Creator/Principal investigator(s)
Magnus Dencker
Variables
33
Number of individuals/objects
248