Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease
Creator/Principal investigator(s)
Magnus Dencker
Description
Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi
Subject area
DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES)
(CESSDA Topic Classification)
Medical and Health Sciences
(The Swedish standard of fields of research 2011)
Principal organisation
Accessibility status
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Responsible department/unit
Creator/Principal investigator(s)
Magnus Dencker
Identifiers
SND-ID: SND 1033
Description
Objective: This study investigated potential associations between novel biomarkers for
cardiovascular disease and other surrogate markers for health.
Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were
measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF,
VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsi
Language
English
Geographic spread
Geographic location: Sweden, Skåne County
Unit of analysis
Time Method
Sampling procedure
Sweden. All 477 children (boys = 259, girls = 218) attending third or fourth grade were invited to participate in the study. Out of these 477 children 248 accepted the invitation (boys = 140, girls = 108), and 172 children gave blood samples (it was optional to do so). Blood samples and a complete data set of other variables were available in 170 children (92 boys and 78 girls) resulting in an inclusion frequency of
36%.
Ethics Review
Lund — Ref. LU 243-01
Biobank is connected to the study
Yes
Subject area
DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES)
(CESSDA Topic Classification)
Medical and Health Sciences
(The Swedish standard of fields of research 2011)
Version 1.0
2017-10-09
https://doi.org/10.5878/002921
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Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
Citation
Creator/Principal investigator(s)
Magnus Dencker
Description
Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray
absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 chil
Data format / data structure
Numeric
Variables
33
Number of individuals/objects
248