Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

SND-ID: SND 1058

Description Data and documentation

Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Description

We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Language

English

Research principal, contributors, and funding

Research principal

Karolinska Institutet

Responsible department/unit

Karolinska Institutet
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Method
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Dataset
Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

Description

Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.

Version 1.0

Citation

Gunnar Johanson. Karolinska Institutet (2018). <em>Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/70kb-5553">https://doi.org/10.5878/70kb-5553</a>

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Data format / data structure

Numeric

Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Time period(s) investigated

2005–2012

Data collection

  • Mode of collection: Experiment
  • Time period(s) for data collection: 2005–2012
  • Source of the data: Biological samples
Published: 2018-09-28