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Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

SND-ID: SND 1058

Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Description

We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Language

English

Research principal, contributors, and funding

Research principal

Karolinska Institutet

Responsible department/unit

Karolinska Institutet
Protection and ethical review
Method and time period
Geographic coverage
Topic and keywords

Research area

Occupational Health and Environmental Health (The Swedish standard of fields of research 2011)
Occupational health (CESSDA Topic Classification)

Keywords

franz cell, permeability coefficient, dermal penetration, diffusion coefficient, flux

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Dataset
Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

Description

Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.

Version 1.0

Citation

Gunnar Johanson. Karolinska Institutet (2018). Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/70kb-5553

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Data format / data structure

Numeric

Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Time period(s) investigated

2005 – 2012

Data collection

  • Mode of collection: Experiment
  • Time period(s) for data collection: 2005–2012
  • Source of the data: Biological samples
Published: 2018-09-28