Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

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Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Description

We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Subject area

Occupational Health and Environmental Health (The Swedish standard of fields of research 2011)
Occupational health (CESSDA Topic Classification)

Keywords

franz cell, permeability coefficient, dermal penetration, diffusion coefficient, flux

Principal organisation

Karolinska Institutet

Responsible department/unit

Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Identifiers

SND-ID: SND 1058

Description

We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Language

English

Subject area

Occupational Health and Environmental Health (The Swedish standard of fields of research 2011)
Occupational health (CESSDA Topic Classification)

Keywords

franz cell, permeability coefficient, dermal penetration, diffusion coefficient, flux

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Version 1.0

2018-09-28
https://doi.org/10.5878/70kb-5553

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Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

Citation

Gunnar Johanson. Karolinska Institutet (2018). <em>Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/70kb-5553">https://doi.org/10.5878/70kb-5553</a>

Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Description

Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.

Data format / data structure

Numeric

Data collection

Mode of collection: Experiment

Time period(s) for data collection: 2005 — 2012

Source of the data: Biological samples

Time period(s) investigated

2005 — 2012

Published: 2018-09-28