Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

Creator/Principal investigator(s):

Gunnar Johanson - Karolinska institutet, Institute of Environmental Medicine

Description:

We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Topic classification:

occupational health, Occupational Health and Environmental Health

Keywords:

Franz cell, permeability coefficient, diffusion coefficient, flux, dermal penetration

Principal organisation:

Karolinska Institute

Accessibility status:

Access to data through SND
Access to data is restricted

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Creator/Principal investigator(s):

Gunnar Johanson - Karolinska institutet, Institute of Environmental Medicine

Identifiers:

SND-ID:

Description:

We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Language:

English

Topic classification:

occupational health, Occupational Health and Environmental Health

Keywords:

Franz cell, permeability coefficient, diffusion coefficient, flux, dermal penetration

Download metadata:

Version 1.0:

2018-09-28 doi:10.5878/70kb-5553

Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

Citation:

Gunnar Johanson (2018). Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/70kb-5553

Description:

Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.

Data format / data structure:

Numeric

Data collection:

2005 — 2012

Mode of collection: Experiment

Data source: Biological samples

Time period(s) investigated:

2005 — 2012