High-risk human papillomavirus status and prognosis in invasive cervical cancer: a nationwide cohort study

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Creator/Principal investigator(s)

Pär Sparén - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics orcid

Description

High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping.

In this nationwide population-based cohort study, we identified all ICC diagnosed in Sweden during the years 2002–2011 (4,254 confirmed cases), requested all archival formalin-fixed paraffin-embedded blocks, and performed HPV genotyping. Twenty out of 25 pathology biobanks agreed to the study, yielding a total of 2,845 confirmed cases with valid HPV results. Cases were prospectively followed up from date of cancer diagnosis to 31 December 2015, migration from Sweden, or death, whichever occurred first. The main exposure was tumor hrHPV status classified as hrHPV-positive and hrHPV-negative. The primary outcome was all-cause mortality by 31 December 2015. Five-year relative survival ratios (RSRs) were calculated,

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Subject area

Creator/Principal investigator(s)

Pär Sparén - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics orcid

Identifiers

SND-ID: SND 1064

Description

High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping.

In this nationwide population-based cohort study, we identified all ICC diagnosed in Sweden during the years 2002–2011 (4,254 confirmed cases), requested all archival formalin-fixed paraffin-embedded blocks, and performed HPV genotyping. Twenty out of 25 pathology biobanks agreed to the study, yielding a total of 2,845 confirmed cases with valid HPV results. Cases were prospectively followed up from date of cancer diagnosis to 31 December 2015, migration from Sweden, or death, whichever occurred first. The main exposure was tumor hrHPV status classified as hrHPV-positive and hrHPV-negative. The primary outcome was all-cause mortality by 31 December 2015. Five-year relative survival ratios (RSRs) were calculated,

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Language

English

Geographic spread

Geographic location: Sweden

Unit of analysis

Population

Women diagnosed as cervical cancer during year 2002-2011 in Sweden

Time Method

Sampling procedure

Other

Ethics Review

Stockholm — Ref. 2011/1026-31/4, 2017/1028/32, 02- 189 556, 2012/1028/32, 2011/921-32

Biobank is connected to the study

Yes

Funding

Funding agency: Swedish Research Council

Funding agency’s reference number: 2014-03732; 2017-02346

Funding agency: Swedish Foundation for Strategic Research, SSF

Funding agency’s reference number: KF10-0046; RB 13-0011

Funding agency: The Swedish Cancer Society

Funding agency’s reference number: 110569; 140665

Subject area

Contact for questions about the data

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Publications

Lei J, Ploner A, Lagheden C, Eklund C, Nordqvist Kleppe S, Andrae B, Elfström KM, Dillner J, Sparén P, Sundström K (2018). High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study. PLoS Med 15(10): e1002666. DOI: 10.1371/journal.pmed.1002666
DOI: https://doi.org/10.1371/j

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Version 1.0

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Dataset 1

High-risk human papillomavirus status and prognosis in invasive cervical cancer: a nationwide cohort study. Dataset 1

Citation

Pär Sparén. Karolinska Institutet, Department of Medical Epidemiology and Biostatistics (2019). <em>High-risk human papillomavirus status and prognosis in invasive cervical cancer: a nationwide cohort study. Dataset 1</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/rtxk-6790">https://doi.org/10.5878/rtxk-6790</a>

Creator/Principal investigator(s)

Pär Sparén - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics orcid

Description

This dataset (ccHPV_RelativeSurvival.dta) comprises 2845 invasive cervical cancer (ICC) cases diagnosed in Sweden during the years 2002-2011, and had valid human papillomavirus (HPV) results assessed from the formalin-fixed, paraffin-embedded (FFPE) blocks.

In order to control the risk of incidental disclosure of personal information, the data available here has been anonymized in the following manner:
• The date of diagnosis has been moved to 2008-07-01 for all subjects.
• Follow-up time has b

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Data format / data structure

Numeric

Data collection

Mode of collection: Aggregation

Time period(s) for data collection: 2002-01-01 — 2015-12-31

Data collector: Statistics Sweden

Source of the data: Population group, Biological samples

Variables

11

Number of individuals/objects

2845

Version 1.0

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Dataset 2

High-risk human papillomavirus status and prognosis in invasive cervical cancer: a nationwide cohort study. Dataset 2

Citation

Pär Sparén. Karolinska Institutet, Department of Medical Epidemiology and Biostatistics (2019). <em>High-risk human papillomavirus status and prognosis in invasive cervical cancer: a nationwide cohort study. Dataset 2</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/vc29-ft86">https://doi.org/10.5878/vc29-ft86</a>

Creator/Principal investigator(s)

Pär Sparén - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics orcid

Description

This is an aggregated dataset (popmort_agg_2000_2015.dta) including the average survival rates of the Swedish female population, by age, for years 2000-2015. The dataset is generated based on the age-, gender- and calender year- specific survival rates of the Swedish population during the same calendar period.

The dataset included 4 variables:
• Sex: Gender (all female): 2=female.
• _age: Age (in years)
• _year: Calendar year
• Prob: Survival probability in corresponding age and calendar year

Data format / data structure

Numeric

Data collection

Mode of collection: Observation

Time period(s) for data collection: 2000-01-01 — 2015-12-31

Data collector: Karolinska Institutet

Source of the data: Population group, Biological samples

Variables

4

Published: 2019-10-21