Creator/Principal investigator(s)
Pär Sparén
- Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
Description
High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping.
In this nationwide population-based cohort study, we identified all ICC diagnosed in Sweden during the years 2002–2011 (4,254 confirmed cases), requested all archival formalin-fixed paraffin-embedded blocks, and performed HPV genotyping. Twenty out of 25 pathology biobanks agreed to the study, yielding a total of 2,845 confirmed cases with valid HPV results. Cases were prospectively followed up from date of cancer diagnosis to 31 December 2015, migration from Sweden, or death, whichever occurred first. The main exposure was tumor hrHPV status classified as hrHPV-positive and hrHPV-negative. The primary outcome was all-cause mortality by 31 December 2015. Five-year relative survival ratios (RSRs) were calculated,
Language
English
Research principal
Responsible department/unit
Department of Medical Epidemiology and Biostatistics
Ethics Review
Stockholm - Ref. 2011/1026-31/4, 2017/1028/32, 02- 189 556, 2012/1028/32, 2011/921-32
Unit of analysis
Population
Women diagnosed as cervical cancer during year 2002-2011 in Sweden
Time Method
Sampling procedure
Biobank is connected to the study
Yes
Geographic spread
Geographic location: Sweden
Research area
HEALTH
(CESSDA Topic Classification)
Medical and Health Sciences
(The Swedish standard of fields of research 2011)
Lei J, Ploner A, Lagheden C, Eklund C, Nordqvist Kleppe S, Andrae B, Elfström KM, Dillner J, Sparén P, Sundström K (2018). High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study. PLoS Med 15(10): e1002666. DOI: 10.1371/journal.pmed.1002666
DOI:
https://doi.org/10.1371/j
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Description
This dataset (ccHPV_RelativeSurvival.dta) comprises 2845 invasive cervical cancer (ICC) cases diagnosed in Sweden during the years 2002-2011, and had valid human papillomavirus (HPV) results assessed from the formalin-fixed, paraffin-embedded (FFPE) blocks.
In order to control the risk of incidental disclosure of personal information, the data available here has been anonymized in the following manner:
• The date of diagnosis has been moved to 2008-07-01 for all subjects.
• Follow-up time has b
Version 1.0
https://doi.org/10.5878/rtxk-6790
Citation
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Data format / data structure
Numeric
Creator/Principal investigator(s)
Pär Sparén
- Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
Variables
11
Number of individuals/objects
2845
Description
This is an aggregated dataset (popmort_agg_2000_2015.dta) including the average survival rates of the Swedish female population, by age, for years 2000-2015. The dataset is generated based on the age-, gender- and calender year- specific survival rates of the Swedish population during the same calendar period.The dataset included 4 variables:
• Sex: Gender (all female): 2=female.
• _age: Age (in years)
• _year: Calendar year
• Prob: Survival probability in corresponding age and calendar year
Version 1.0
https://doi.org/10.5878/vc29-ft86
Citation
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Data format / data structure
Numeric
Creator/Principal investigator(s)
Pär Sparén
- Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
Keywords
Variables
4