Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda

Creator/Principal investigator(s):

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Description:

Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.

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Keywords:

Creator/Principal investigator(s):

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Identifiers:

SND-ID: SND 1065

Purpose:

To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.

Description:

Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.

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Language:

English

Ethics Review:

Uganda National Council of Science and Technology —HR 1959

Keywords:

Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among SMC men

Principal investigator(s):

Description:

Observations: 1,217 variables: 14 size: 116,832 Social demographics, TT antibody concentration, interpretation of concentration, participant identification variable

Data format / data structure:

Numeric

Data collection:

Mode of collection: Interview

Time period(s) for data collection: 2016-01-10 — 2016-11-02

Source of the data: Population group

Mode of collection: Measurements and tests

Time period(s) for data collection: 2016-01-10 — 2016-11-02

Source of the data: Population group

Variables:

14

Number of individuals/objects:

620

Response rate/participation rate:

620/769 (80.6%)