Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda

SND-ID: SND 1065

Description Data and documentation

Creator/Principal investigator(s)

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Description

Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.

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Language

English

Research principal, contributors, and funding
Protection and ethical review

Ethics Review

Uganda National Council of Science and Technology - Ref. HR 1959

Method and time period
Geographic coverage

Geographic spread

Geographic location: Uganda

Geographic description: 13 sites in the 5 geographical regions (North, Western, Eastern Central and Kampala

Topic and keywords

Research area

HEALTH (CESSDA Topic Classification)
Medical and Health Sciences (The Swedish standard of fields of research 2011)

Keywords

tetanus toxoid

Publications
Dataset
Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among SMC men

Description

Observations: 1,217 variables: 14 size: 116,832 Social demographics, TT antibody concentration, interpretation of concentration, participant identification variable

Data format / data structure

Numeric

Creator/Principal investigator(s)

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Data collection 1

  • Mode of collection: Interview
  • Time period(s) for data collection: 2016-01-10–2016-11-02
  • Source of the data: Population group

Data collection 2

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 2016-01-10–2016-11-02
  • Source of the data: Population group

Variables

14

Number of individuals/objects

620

Response rate/participation rate

620/769 (80.6%)

Published: 2019-01-14
Last updated: 2020-02-14