Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda

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Creator/Principal investigator(s)

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Description

Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.

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Subject area

Keywords

Responsible department/unit

Uganda Ministry of Health, AIDS Control Program

Creator/Principal investigator(s)

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Identifiers

SND-ID: SND 1065

Description

Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.

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Language

English

Geographic spread

Geographic location: Uganda

Geographic description: 13 sites in the 5 geographical regions (North, Western, Eastern Central and Kampala

Ethics Review

Uganda National Council of Science and Technology — Ref. HR 1959

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Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among SMC men

Creator/Principal investigator(s)

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Description

Observations: 1,217 variables: 14 size: 116,832 Social demographics, TT antibody concentration, interpretation of concentration, participant identification variable

Data format / data structure

Numeric

Data collection

Mode of collection: Interview

Time period(s) for data collection: 2016-01-10 — 2016-11-02

Source of the data: Population group

Mode of collection: Measurements and tests

Time period(s) for data collection: 2016-01-10 — 2016-11-02

Source of the data: Population group

Variables

14

Number of individuals/objects

620

Response rate/participation rate

620/769 (80.6%)

Published: 2019-01-14
Last updated: 2020-02-14