Creator/Principal investigator(s)
Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health
Description
Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.
Language
English
Research principal
Ethics Review
Uganda National Council of Science and Technology - Ref. HR 1959
Geographic spread
Geographic location: Uganda
Geographic description: 13 sites in the 5 geographical regions (North, Western, Eastern Central and Kampala
Research area
HEALTH
(CESSDA Topic Classification)
Medical and Health Sciences
(The Swedish standard of fields of research 2011)
Keywords
Makumbi F, Byabagambi J, Muwanika R, Kigozi G, Gray R, et al. (2018) Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda. PLOS ONE 13(12): e0209167. https://doi.org/10.1371/journal.pone.0209167
DOI:
https://doi.org/10.1371/journal.pone.0209167
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Description
Observations: 1,217 variables: 14 size: 116,832 Social demographics, TT antibody concentration, interpretation of concentration, participant identification variableVersion 1.0
https://doi.org/10.5878/2vmc-5511
Citation
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Data format / data structure
Numeric
Creator/Principal investigator(s)
Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health
Variables
14
Number of individuals/objects
620
Response rate/participation rate
620/769 (80.6%)