The effect of inactin on kidney mitochondrial function and production of reactive oxygen species

Creator/Principal investigator(s):

Fredrik Palm - Uppsala University, Department of Cell Biology

Tomas Schiffer - Uppsala University, Department of Cell Biology

Description:

Inactin is an anesthetic agent commonly used in rat studies, but is also shown to exert physiological effects such as reducing renal blood flow, glomerular filtration rate and depressing tubular transport capacity. It is unknown whether inactin also effects isolated kidney mitochondria which may be important when studying related topics in anaesthetized animals. The aim of this study was to evaluate whether inactin exerts effects on mitochondrial function and production of reactive oxygen species. Kidney mitochondrial function and reactive oxygen production after acutely (5 min) or longer (1.5 hour) anesthetizing rats with inactin was determined by using high-resolution respirometry.

Topic classification:

Medical and Health Sciences

Principal organisation:

Uppsala University

Accessibility status:

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Data are freely accessible

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SND 1068 Data and documentation.zip (302.5 KB)
Data and documentation

Creator/Principal investigator(s):

Fredrik Palm - Uppsala University, Department of Cell Biology

Tomas Schiffer - Uppsala University, Department of Cell Biology

Identifiers:

SND-ID:

Description:

Inactin is an anesthetic agent commonly used in rat studies, but is also shown to exert physiological effects such as reducing renal blood flow, glomerular filtration rate and depressing tubular transport capacity. It is unknown whether inactin also effects isolated kidney mitochondria which may be important when studying related topics in anaesthetized animals. The aim of this study was to evaluate whether inactin exerts effects on mitochondrial function and production of reactive oxygen species. Kidney mitochondrial function and reactive oxygen production after acutely (5 min) or longer (1.5 hour) anesthetizing rats with inactin was determined by using high-resolution respirometry.

Topic classification:

Medical and Health Sciences

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Version 1.0:

2018-11-12 doi:10.5878/6m1n-7j65

Download data:

SND 1068 Data and documentation.zip (302.5 KB)
Data and documentation

The effect of inactin on kidney mitochondrial function and production of reactive oxygen species

Citation:

Fredrik Palm, Tomas Schiffer (2018). The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/6m1n-7j65

Data format / data structure:

Numeric