The effect of inactin on kidney mitochondrial function and production of reactive oxygen species

Principal investigator(s):

Fredrik Palm - Uppsala University, Department of Cell Biology

Tomas Schiffer - Uppsala University, Department of Cell Biology

Description:

Inactin is an anesthetic agent commonly used in rat studies, but is also shown to exert physiological effects such as reducing renal blood flow, glomerular filtration rate and depressing tubular transport capacity. It is unknown whether inactin also effects isolated kidney mitochondria which may be important when studying related topics in anaesthetized animals. The aim of this study was to evaluate whether inactin exerts effects on mitochondrial function and production of reactive oxygen species. Kidney mitochondrial function and reactive oxygen production after acutely (5 min) or longer (1.5 hour) anesthetizing rats with inactin was determined by using high-resolution respirometry.

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Principal investigator(s):

Fredrik Palm - Uppsala University, Department of Cell Biology

Tomas Schiffer - Uppsala University, Department of Cell Biology

Principal organisation:

Description:

Inactin is an anesthetic agent commonly used in rat studies, but is also shown to exert physiological effects such as reducing renal blood flow, glomerular filtration rate and depressing tubular transport capacity. It is unknown whether inactin also effects isolated kidney mitochondria which may be important when studying related topics in anaesthetized animals. The aim of this study was to evaluate whether inactin exerts effects on mitochondrial function and production of reactive oxygen species. Kidney mitochondrial function and reactive oxygen production after acutely (5 min) or longer (1.5 hour) anesthetizing rats with inactin was determined by using high-resolution respirometry.

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Biological samples

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The effect of inactin on kidney mitochondrial function and production of reactive oxygen species

Citation:

Fredrik Palm, Tomas Schiffer (2018). The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/6m1n-7j65