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The effect of inactin on kidney mitochondrial function and production of reactive oxygen species

SND-ID: SND 1068

Creator/Principal investigator(s)

Fredrik Palm - Uppsala University, Department of Cell Biology

Tomas Schiffer - Uppsala University, Department of Cell Biology

Description

Inactin is an anesthetic agent commonly used in rat studies, but is also shown to exert physiological effects such as reducing renal blood flow, glomerular filtration rate and depressing tubular transport capacity. It is unknown whether inactin also effects isolated kidney mitochondria which may be important when studying related topics in anaesthetized animals. The aim of this study was to evaluate whether inactin exerts effects on mitochondrial function and production of reactive oxygen species. Kidney mitochondrial function and reactive oxygen production after acutely (5 min) or longer (1.5 hour) anesthetizing rats with inactin was determined by using high-resolution respirometry.
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Research principal

Uppsala University

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Uppsala University
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Research area

Medical and Health Sciences (The Swedish standard of fields of research 2011)

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The effect of inactin on kidney mitochondrial function and production of reactive oxygen species

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Citation

Fredrik Palm, Tomas Schiffer. Uppsala University (2018). The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/6m1n-7j65

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Creator/Principal investigator(s)

Fredrik Palm - Uppsala University, Department of Cell Biology

Tomas Schiffer - Uppsala University, Department of Cell Biology

Published: 2018-11-12
Last updated: 2019-02-08