Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking

Creator/Principal investigator(s):

Morten Kraen - Lund University and Region Skåne

Description:

Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods: 417 subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and -12

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Responsible department/unit:

Lund University

Creator/Principal investigator(s):

Morten Kraen - Lund University and Region Skåne

Identifiers:

SND-ID: SND 1084

Description:

Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods: 417 subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and -12

Ethics Review:

Lund — Ref. 786-03 med komplettering för biomarköranalys 2015-03-11

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Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking M. Kraen, S. Frantz, U. Nihlén, G. Engström, C. G. Löfdahl, P. Wollmer & M. Dencker, 2019 Feb 21, In : PLoS ONE. 14, 2, e0211987.
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DOI: https://doi.org/10.1371/journal.pone.0211987

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Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking

Suggested citation:

Morten Kraen. Lund University (2019). <em>Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking</em>. Swedish National Data Service. Version 1.0. <a href="https://doi.org/10.5878/eybp-ex91">https://doi.org/10.5878/eybp-ex91</a>

Creator/Principal investigator(s):

Morten Kraen - Lund University and Region Skåne

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Published: 2019-02-06
Last updated: 2020-02-20