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Cell to cell signaling via exosomes (transport of genetic material between cells via exosomes)

SND-ID: SND 1142

Creator/Principal investigator(s)

Hadi Valadi - University of Gothenburg, Avdelningen för reumatologi och inflammationsforskning orcid

Description

In the human body, communication between cells takes place in several different ways. Exosomes are a type of extracellular vesicles (30-200 nm in diameter) that also participate in this process. Exosomes can be released from most cell types in the body and exist naturally in different body fluids, such as blood.

In 2007, we showed for the first time that exosomes also transport RNA molecules (both coding and non-coding RNA molecules) between cells (Valadi H. et al. Nature Cell Biology. 2007). The findings describe a new type of 'cell-cell' communication by which different cells send genetic messages to each other by secreting vesicles (exosomes) containing specific RNA molecules.

Our current studies aim to (a) identify cellular actors involved in translocation (packaging) of RNA into exosomes during their biosynthesis, (b) identify the mechanism by which exosomes are taken up by recipient cells/ tissues, and (c) ) discover a method to introduce exogenous/ therapeutic RNA into exosomes, to be used for in vivo transport of therapeutic RNA to different organs.

Language

English

Research principal, contributors, and funding

Research principal

University of Gothenburg

Responsible department/unit

the Institute of Medicine

Identifiers

ProjektID: Exosome RNA

Protection and ethical review
Method and time period

Unit of analysis

Population

Currently, not available

Study design

Experimental study

Preclinical study

Time period(s) investigated

2008-01-01 – ongoing

Geographic coverage

Geographic spread

Geographic location: Sweden

Topic and keywords

Research area

Natural Sciences, Medical and Health Sciences (The Swedish standard of fields of research 2011)

Keywords

cell communication, extracellular matrix, rna transport, exosomes

Publications

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Maugeri M, Nawaz M, Papadimitriou A, Angerfors A, Camponeschi A, Na M, Hölttä M, Skantze P, Johansson S, Sundqvist M, Lindquist J, Kjellman T, Mårtensson IL, Jin T, Sunnerhagen P, Östman S, Lindfors L, Valadi H., Nature Communication. 2019 Sep 24;10(1):4333. https://doi.org/10.1038/s41467-019-12275-6
Link to article
DOI: https://doi.org/10.1038/s41467-019-12275-6

Statello L, Maugeri M, Garre E, Nawaz M, Wahlgren J, Papadimitriou A, et al. (2018) Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes. PLoS ONE 13(4): e0195969. https://doi.org/10.1371/journal.pone.0195969
Link to article
DOI: https://doi.org/10.1371/journal.pone.0195969. eCollection 2018

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Dataset
Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

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Description

RNA-binding proteins (RBPs) present in exosomes derived from HTB177 cells (NCI-H460 [H460] (ATCC: HTB-177) were identified as described below.

For more detailed description please see Statello L, Maugeri M, Garre E, Nawaz M, Wahlgren J, Papadimitriou A, et al. (2018) (doi: 10.1371/journal.pone.0195969. eCollection 2018). List of the identified proteins can be found in the section 'Data collection' as well as on the journal's website (https://journals.plos.org/plosone/article?id=10.1371/journal

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Citation

Hadi Valadi. University of Gothenburg (2020). Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes. Swedish National Data Service. Version 1.0. https://doi.org/10.5878/6b1e-fs87

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Data format / data structure

Text

Creator/Principal investigator(s)

Hadi Valadi - University of Gothenburg, Avdelningen för reumatologi och inflammationsforskning orcid

Data collection

  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 2008
  • Source of the data: Research data

URL

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195969#sec025

Published: 2020-01-31