10.5878/70kb-5553
Johanson, Gunnar
Gunnar
Johanson
Institute of Environmental Medicine, Karolinska Institutet
Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin
Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin
Karolinska Institutet
2018
Franz cell
Franz cell
permeability coefficient
permeability coefficient
diffusion coefficient
diffusion coefficient
flux
flux
dermal penetration
dermal penetration
Occupational Health and Environmental Health
Arbetsmedicin och miljömedicin
Occupational health
Arbets- och miljömedicin
Health Sciences
Hälsovetenskap
HEALTH
HÄLSA
Medical and Health Sciences
Medicin och hälsovetenskap
2018-09-28
2005/2012
2005/2012
eng
10.5878/3w55-mx72
1.0
We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.
Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.
We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.
Experimentella data för varje ämne och spädning rapporteras i ett excelark. Toppareor från gaskromatografiska analyser och beräknade hudupptagsparametrar för varje enskild experiment rapporteras.