A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1

SND-ID: 2020-51

Description Data and documentation

Creator/Principal investigator(s)

Gustav Nilsonne, KI - Karolinska Institutet, Department of Clinical Neuroscience orcid

Sandra Tamm - Karolinska Institutet, Department of Clinical Neuroscience orcid

Paolo d'Onofrio - Stockholm University, Stress Research Institute

Hanna Thuné - Stockholm University, Stress Research Institute

Johanna Schwarz - Stockholm University, Department of Psychology orcid

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Description

The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep deprivation in a crossover design. We performed experiments investigating emotional mimicry, empathy for pain, and cognitive reappraisal, as well as resting state functional magnetic resonance imaging (fMRI). We also acquired T1- and T2-weighted structural images and diffusion tensor images (DTI). On the night before imaging, participants were monitored with ambulatory polysomnography and were instructed to sleep either as usual or only three hours. Participants came to the scanner the following evening. Besides MRI scanning, participants underwent behavioral tests and contributed blood samples, which have been stored in a biobank and used for DNA analyses. Participants also completed a variety of self-report measures. The resulting multimodal dataset may be useful for hypothesis generation or independent validation of effects of sleep deprivation and aging, as well as investigati

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Language

English

Research principal, contributors, and funding

Research principal

Karolinska Institutet

Contributor(s)

Stockholm University, Stress Research Institute rorId

Funding 1

  • Funding agency: Fredrik and Ingrid Thuring Foundation rorId
  • Funding agency's reference number: 2014-00037, 2015-00170

Funding 2

  • Funding agency: Riksbankens Jubileumsfond rorId
  • Funding agency's reference number: P15-0310:1
Protection and ethical review

Data contains personal data

No

Ethics Review

Stockholm - Ref. 2012/1098-31/2

Method and time period

Unit of analysis

Population

Healthy volunteers

Study design

Double-blind randomised trial

Time period(s) investigated

2012-12-04–2013-03-27

2013-10-24–2014-04-29

Biobank is connected to the study

Yes

Geographic coverage
Publications

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Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J, Petrovic P, Månsson KNT. Gray matter volume correlates of sleepiness: a voxel–based morphometry study in younger and older adults. Nature and Science of Sleep 2020, 12, 289-198.
DOI: https://doi.org/10.2147/NSS.S240493

Nilsonne G, Tamm S, d’Onofrio P, Thuné HÅ, Schwarz J, Lavebratt C, Liu, JJ, Månsson KNT, Sundelin T, Axelsson J, Fransson P, Kecklund G, Fischer H, Lekander M, Åkerstedt Torbjörn. A multimodal brain imaging dataset on sleep deprivation in young and old humans. Karolinska Open Archive. url: http://hdl.handle.net/10616/45181
Handle: 10616/45181

Koba C, Notaro G, Tamm S, Nilsonne G, Hasson U. Spontaneous eye-movements during eyes-open rest reduce resting-state-network modularity by increasing visual-sensorimotor connectivity. bioRχiv. doi: 10.1101/2020.05.18.100669
DOI: https://doi.org/10.1101/2020.05.18.100669

Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J. Effects of late night short sleep on in-home polysomnography – relation to adult age and sex. Journal of Sleep Research 2017. doi: 10.1111/jsr.12626
DOI: https://doi.org/10.1111/jsr.12626

Tamm S, Nilsonne G, Lamm C, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. The effect of sleep restriction on empathy for pain: An fMRI study in younger and older adults. Scientific Reports 2017 7:12236. doi: 10.1038/s41598-017-12098-9
DOI: https://doi.org/10.1038/s41598-017-12098-9

Tamm S, Nilsonne G, Schwarz J, Golkar A, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study. Royal Society Open Science, 6(3), 181704. doi: 10.1098/rsos.181704
DOI: https://doi.org/10.1098/rsos.181704

Nilsonne G, Tamm S, Schwarz J, Almeida R, Fischer H, Kecklund G, Lekander M, Fransson P, Åkerstedt T. Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain Study. Scientific Reports 2017 7:9422. doi: 10.1038/s41598-017-09744-7
DOI: https://doi.org/10.1038/s41598-017-09744-7

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Dataset
A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1, version 3

Description

The dataset is available for download with the tool Datalad (https://www.datalad.org/). The command after installing Datalad is:
datalad install -r https://github.com/NilsonneData/SleepyBrain1.git

Earlier versions of this dataset can be found here: https://openneuro.org/datasets/ds000201/versions/1.0.3

Version 1

Citation

Gustav Nilsonne, KI. Karolinska Institutet, Department of Clinical Neuroscience (2021). <em>A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1, version 3</em>. Swedish National Data Service. Version 1. <a href="https://doi.org/10.5878/87y5-kh22">https://doi.org/10.5878/87y5-kh22</a>

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Data format / data structure

Numeric

Text

Other

Creator/Principal investigator(s)

Gustav Nilsonne, KI - Karolinska Institutet, Department of Clinical Neuroscience orcid

Data collection

  • Mode of collection: Measurements and tests
  • Data collector: Karolinska Institutet
  • Source of the data: Other

Number of individuals/objects

90

Contact for questions about the data

This resource has the following relations

Published: 2020-07-15
Last updated: 2021-11-01