A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1

Creator/Principal investigator(s):

Gustav Nilsonne, KI - Karolinska Institutet, Department of Clinical Neuroscience orcid

Sandra Tamm - Karolinska Institutet, Department of Clinical Neuroscience orcid

Paolo d'Onofrio - Stockholm University, Stress Research Institute

Hanna Thuné - Stockholm University, Stress Research Institute

Johanna Schwarz - Stockholm University, Department of Psychology orcid

Catharina Lavebratt - Karolinska Institutet, Department of molecular medicine and surgery orcid

Jia Jia Liu - Karolinska Institutet, Department of molecular medicine and surgery

Kristoffer N. T. Månsson - Karolinska Institutet, Department of Clinical Neuroscience orcid

Tina Sundelin - Stockholm University, Department of Psychology orcid

John Axelsson - Stockholm University, Stress Research Institute orcid

Claus Lamm - University of Vienna, Faculty of Psychology orcid

Predrag Petrovic - Karolinska Institutet, Department of Clinical Neuroscience orcid

Peter Fransson - Karolinska Institutet, Department of Clinical Neuroscience orcid

Göran Kecklund - Stockholm University, Stress Research Institute

Håkan Fischer - Stockholm University, Department of Psychology orcid

Mats Lekander - Stockholm University, Stress Research Institute

Torbjörn Åkerstedt - Stockholm University, Stress Research Institute orcid

Description:

The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep deprivation in a crossover design. We performed experiments investigating emotional mimicry, empathy for pain, and cognitive reappraisal, as well as resting state functional magnetic resonance imaging (fMRI). We also acquired T1- and T2-weighted structural images and diffusion tensor images (DTI). On the night before imaging, participants were monitored with ambulatory polysomnography and were instructed to sleep either as usual or only three hours. Participants came to the scanner the following evening. Besides MRI scanning, participants underwent behavioral tests and contributed blood samples, which have been stored in a biobank and used for DNA analyses. Participants also completed a variety of self-report measures. The resulting multimodal dataset may be useful for hypothesis generation or independent validation of effects of sleep deprivation and aging, as well as investigati

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Responsible department/unit:

Karolinska Institutet, Department of Clinical Neuroscience

Creator/Principal investigator(s):

Gustav Nilsonne, KI - Karolinska Institutet, Department of Clinical Neuroscience orcid

Sandra Tamm - Karolinska Institutet, Department of Clinical Neuroscience orcid

Paolo d'Onofrio - Stockholm University, Stress Research Institute

Hanna Thuné - Stockholm University, Stress Research Institute

Johanna Schwarz - Stockholm University, Department of Psychology orcid

Catharina Lavebratt - Karolinska Institutet, Department of molecular medicine and surgery orcid

Jia Jia Liu - Karolinska Institutet, Department of molecular medicine and surgery

Kristoffer N. T. Månsson - Karolinska Institutet, Department of Clinical Neuroscience orcid

Tina Sundelin - Stockholm University, Department of Psychology orcid

John Axelsson - Stockholm University, Stress Research Institute orcid

Claus Lamm - University of Vienna, Faculty of Psychology orcid

Predrag Petrovic - Karolinska Institutet, Department of Clinical Neuroscience orcid

Peter Fransson - Karolinska Institutet, Department of Clinical Neuroscience orcid

Göran Kecklund - Stockholm University, Stress Research Institute

Håkan Fischer - Stockholm University, Department of Psychology orcid

Mats Lekander - Stockholm University, Stress Research Institute

Torbjörn Åkerstedt - Stockholm University, Stress Research Institute orcid

Contributor(s):

Stockholm University, Stress Research Institute rorid

Identifiers:

SND-ID: 2020-51

Description:

The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep deprivation in a crossover design. We performed experiments investigating emotional mimicry, empathy for pain, and cognitive reappraisal, as well as resting state functional magnetic resonance imaging (fMRI). We also acquired T1- and T2-weighted structural images and diffusion tensor images (DTI). On the night before imaging, participants were monitored with ambulatory polysomnography and were instructed to sleep either as usual or only three hours. Participants came to the scanner the following evening. Besides MRI scanning, participants underwent behavioral tests and contributed blood samples, which have been stored in a biobank and used for DNA analyses. Participants also completed a variety of self-report measures. The resulting multimodal dataset may be useful for hypothesis generation or independent validation of effects of sleep deprivation and aging, as well as investigati

... Show more..

Language:

English

Time period(s) investigated:

2012-12-04 — 2013-03-27

2013-10-24 — 2014-04-29

Unit of analysis:

Population:

Healthy volunteers

Study design:

Double-blind randomised trial

Data contains personal data:

Yes

Ethics Review:

Stockholm — Ref. 2012/1098-31/2

Biobank is connected to the study:

Yes

Funding:

Fredrik and Ingrid Thuring Foundation — Ref. 2014-00037, 2015-00170

Riksbankens Jubileumsfond — Ref. P15-0310:1

Contact for questions about the data:

Gustav Nilsonne, KI

This resource has the following relations:

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Publications

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Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J, Petrovic P, Månsson KNT. Gray matter volume correlates of sleepiness: a voxel–based morphometry study in younger and older adults. Nature and Science of Sleep 2020, 12, 289-198.
DOI: 10.2147/NSS.S240493

Nilsonne G, Tamm S, d’Onofrio P, Thuné HÅ, Schwarz J, Lavebratt C, Liu, JJ, Månsson KNT, Sundelin T, Axelsson J, Fransson P, Kecklund G, Fischer H, Lekander M, Åkerstedt Torbjörn. A multimodal brain imaging dataset on sleep deprivation in young and old humans. Karolinska Open Archive. url: http://hdl.handle.net/10616/45181
Handle: 10616/45181

Koba C, Notaro G, Tamm S, Nilsonne G, Hasson U. Spontaneous eye-movements during eyes-open rest reduce resting-state-network modularity by increasing visual-sensorimotor connectivity. bioRχiv. doi: 10.1101/2020.05.18.100669
DOI: 10.1101/2020.05.18.100669

Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J. Effects of late night short sleep on in-home polysomnography – relation to adult age and sex. Journal of Sleep Research 2017. doi: 10.1111/jsr.12626
DOI: 10.1111/jsr.12626

Tamm S, Nilsonne G, Lamm C, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. The effect of sleep restriction on empathy for pain: An fMRI study in younger and older adults. Scientific Reports 2017 7:12236. doi: 10.1038/s41598-017-12098-9
DOI: 10.1038/s41598-017-12098-9

Tamm S, Nilsonne G, Schwarz J, Golkar A, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study. Royal Society Open Science, 6(3), 181704. doi: 10.1098/rsos.181704
DOI: 10.1098/rsos.181704

Nilsonne G, Tamm S, Schwarz J, Almeida R, Fischer H, Kecklund G, Lekander M, Fransson P, Åkerstedt T. Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain Study. Scientific Reports 2017 7:9422. doi: 10.1038/s41598-017-09744-7
DOI: 10.1038/s41598-017-09744-7

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License:

CC0

A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1

Creator/Principal investigator(s):

Gustav Nilsonne, KI - Karolinska Institutet, Department of Clinical Neuroscience orcid

Data format / data structure:

Numeric

Text

Other

Data collection:

Mode of collection: Measurements and tests

Time period(s) for data collection:

Data collector: Karolinska Institutet

Source of the data: Other

Number of individuals/objects:

90

Published: 2020-07-15