The MDC was started in the early 1990s as a screening survey in the middle-aged population of Malmö, the third largest city of Sweden. 28000 subjects living in Malmö were during 1991-1996 invited by letter and through public advertisement to a clinical examination whitch included blood sampling and a questionnaire about nutrition. 62 % of the participants were women. Cardiovascular risk factors were measured in a random subsample (n= 6000). After 16 years, during 2007-2012, a new clinical examination and blood sampling was performed (n=3700). Morbidity and mortality have been followed up by national registers.