Skapare/primärforskare
Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health
Beskrivning
Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.
Språk
Engelska
Forskningshuvudman
Etikprövning
Uganda National Council of Science and Technology - dnr HR 1959
Geografisk utbredning
Geografisk plats: Uganda
Geografisk beskrivning: 13 sites in the 5 geographical regions (North, Western, Eastern Central and Kampala
Forskningsområde
HÄLSA
(CESSDA Topic Classification)
Medicin och hälsovetenskap
(Standard för svensk indelning av forskningsämnen 2011)
Nyckelord
Beskrivning
Observations: 1,217 variables: 14 size: 116,832 Social demographics, TT antibody concentration, interpretation of concentration, participant identification variableDataformat / datastruktur
Numeriska
Skapare/primärforskare
Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health
Variabler
14
Antal individer/objekt
620
Svarsfrekvens/deltagarfrekvens
620/769 (80.6%)