Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda

SND-ID: SND 1065

Skapare/primärforskare

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Beskrivning

Introduction: Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).
Objective: To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.
Methods: We enrolled 620 consenting men who completed a questionnaire and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.
Results: Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported ever receipt of TTCV, and 16.8% had current/recently healed wounds. Insufficient tetanus immunity was 57.1% at enrollment, 7.2% at day 14, 3.8% at day 28, and 0% at day 42. Antibody concentration was 0.44IU/ml (CI 0.

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Språk

Engelska

Huvudman, medverkande och finansiering
Skyddsvärde och etikprövning

Etikprövning

Uganda National Council of Science and Technology - dnr HR 1959

Metod och tidsperiod
Geografisk täckning

Geografisk utbredning

Geografisk plats: Uganda

Geografisk beskrivning: 13 sites in the 5 geographical regions (North, Western, Eastern Central and Kampala

Ämnesområde och nyckelord

Forskningsområde

HÄLSA (CESSDA Topic Classification)
Medicin och hälsovetenskap (Standard för svensk indelning av forskningsämnen 2011)

Nyckelord

stelkrampsvaccin

Publikationer
Dataset
Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among SMC men

Beskrivning

Observations: 1,217 variables: 14 size: 116,832 Social demographics, TT antibody concentration, interpretation of concentration, participant identification variable

Dataformat / datastruktur

Numeriska

Skapare/primärforskare

Fredrick Makumbi - Makerere University, College of Health Science, School of Public Health

Datainsamling 1

  • Insamlingsmetod: Intervju
  • Tidsperiod(er) för datainsamling: 2016-01-10–2016-11-02
  • Datakälla: Befolkningsgrupp

Datainsamling 2

  • Insamlingsmetod: Mätningar och tester
  • Tidsperiod(er) för datainsamling: 2016-01-10–2016-11-02
  • Datakälla: Befolkningsgrupp

Variabler

14

Antal individer/objekt

620

Svarsfrekvens/deltagarfrekvens

620/769 (80.6%)

Publicerad: 2019-01-14
Senast uppdaterad: 2020-02-14